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OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. Additionally we are shipping OTUD5 Antibodies (43) and many more products for this protein.
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Findings have uncovered an apoptotic signaling cascade linking PDCD5 (show PDCD5 Proteins), OTUD5, and p53 (show TP53 Proteins) during genotoxic stress responses.
OTUD5 is required for the stabilization and the activation of a p53 (show TP53 Proteins) response
Here the authors show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme.
data identify DUBA as a negative regulator of innate immune responses
data identify DUBA as a cell-intrinsic suppressor of IL-17 (show IL17A Proteins) production
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
OTU domain containing 5
, OTU domain-containing protein 5
, OTU domain-containing protein 5-A
, deubiquitinating enzyme A
, deubiquinating enzyme A