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Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Additionally we are shipping Organic Solute Transporter alpha Kits (3) and Organic Solute Transporter alpha Proteins (3) and many more products for this protein.
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Human Polyclonal OSTALPHA Primary Antibody for EIA, FACS - ABIN953943
Renner, Harsch, Strohmeyer, Schimmel, Stange: Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. in Journal of lipid research 2008
Hepatic OSTalpha-OSTbeta (show OSTBETA Antibodies) expression is induced by hypoxia.
Ostbeta (show OSTBETA Antibodies) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (show OSTBETA Antibodies) critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (show OSTBETA Antibodies) in different tissues.
OSTalpha has roles in biological transport and is widely expressed in human tissues
overexpression of hu (show OSTBETA Antibodies)man OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (show NR1H4 Antibodies) and the activation of FXR target genes
OSTalpha/OSTbeta (show OSTBETA Antibodies) expression is induced by bile acids through ligand-dependent transactivation of both OST (show DDOST Antibodies) genes by the nuclear bile acid receptor (show NR1H4 Antibodies)/farnesoid X receptor (show xpr1 Antibodies) (FXR (show NR1H4 Antibodies)).
the selective localization of OSTalpha and OSTbeta (show OSTBETA Antibodies) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
These results indicate that expression of Ostalpha and Ostbeta (show OSTBETA Antibodies) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (show NR1H4 Antibodies).
Demonstrate association of OST-alpha and OST-beta (show OSTBETA Antibodies) to determine trafficking to plasma membrane and activity.
The mRNA expression of OSTalpha-OSTbeta (show OSTBETA Antibodies) was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta (show OSTBETA Antibodies): 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers
These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin (show INS Antibodies) resistance.
Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE (show APOE Antibodies)(-/-) mice deficient in Ostalpha.
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
Inactivation of FXR (show NR1H4 Antibodies) largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.
Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.
OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (show SULT2A1 Antibodies) homeostasis
These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.
Co-expression of mouse Ostalpha-Ostbeta (show OSTBETA Antibodies), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha and OSTbeta (show OSTBETA Antibodies) mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (show NR1H4 Antibodies)-/-, mice
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter alpha
, organic solute transporter subunit alpha
, organic solute transporter, alpha subunit
, solute carrier family 51 subunit alpha