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Osteopetrosis Associated Transmembrane Protein 1 Proteins (OSTM1)

OSTM1 encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. Additionally we are shipping OSTM1 Antibodies (43) and OSTM1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OSTM1 28962 Q86WC4
OSTM1 14628 Q8BGT0
Rat OSTM1 OSTM1 499474  
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Top OSTM1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$437.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

OSTM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,

Top referenced OSTM1 Proteins

  1. Human OSTM1 Protein expressed in Human Cells - ABIN2003600 : Chalhoub, Benachenhou, Rajapurohitam, Pata, Ferron, Frattini, Villa, Vacher: Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. in Nature medicine 2003 (PubMed)
    Show all 2 references for ABIN2003600

More Proteins for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Interaction Partners

Human Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) interaction partners

  1. KIF5B is essential for Ostm1 intracellular dispersion.

  2. Ostm1 has a primary and autonomous role in neuronal homeostasis

  3. Common gating underlies the slow voltage activation of ClC-7 (show CLCN7 Proteins).

  4. we describe for the first time homozygous microdeletions of different sizes affecting the OSTM1 gene in two unrelated consanguineous families with children suffering from neuronopathic infantile malignant osteopetrosi

  5. The authors show that both the aminoterminus and transmembrane span of the Ostm1 beta-subunit (show POLG Proteins) are required for ClC-7 (show CLCN7 Proteins) Cl(-)/H(+)-exchange, whereas the Ostm1 transmembrane domain suffices for its ClC-7 (show CLCN7 Proteins)-dependent trafficking to lysosomes.

  6. mutation in the human GL gene leads to severe recessive osteopetros (show CSF1 Proteins)is

  7. The human GIPN gene has 6 exons and 5 introns, and encodes a 334-aa protein.

  8. A novel mutation affecting the OSTM1 locus responsible for ARO (show CYP19A1 Proteins). In addition to common clinical features of osteopetrosis (show CSF1 Proteins), the patient developed a unique neuronal pathology that provided evidence for the role of OSTM1 in normal neuronal cell development.

  9. This study reports on a 12-month-old female with recessive OSMT1 mutations and neuroimaging findings suggesting a malignant infantile osteopetrosis (show CSF1 Proteins).

  10. mutations in OSTM1 such as the C-terminal deletion mutant studied herein provoke dysregulation of the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway, providing a molecular basis for severe autosomal recessive osteopetrosis (show CSF1 Proteins)

Mouse (Murine) Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) interaction partners

  1. KIF5B is essential for Ostm1 intracellular dispersion.

  2. Truncated OSTM1 significantly inhibited the expression of osteoclast marker genes through the down-regulation of the BLIMP1 (show PRDM1 Proteins)-NFATc1 (show NFATC1 Proteins) axis.

  3. Our in vivo structure-function analysis of ClC-7 (show CLCN7 Proteins) reveals that both protein-protein interactions and ion transport must be considered in the pathogenesis of ClC-7 (show CLCN7 Proteins)-related diseases.

  4. Ostm1 has a primary and autonomous role in neuronal homeostasis

  5. Omi (show HTRA2 Proteins) is a recessive mutation in the Ostm1 gene affecting teeth and coat color.

  6. Ostm1 is a bona fide target of miR (show MLXIP Proteins)-140, which is significantly decreased during adipogenic differentiation.

  7. Neuropathologic changes similar to neuronal ceroid lipofuscinosis (show CLN6 Proteins) are found in osteoporosis associated transmembrane protein 1 (show TMEM1 Proteins) (Ostml)-deficient mice.

  8. mutation induces severe malignant autosomal recessive osteopetrosis (show CSF1 Proteins); studies show that Gl protein function is absolutely required for osteoclast and melanocyte maturation and function

  9. both ClC-7 (show CLCN7 Proteins) and Ostm1 proteins co-localize in late endosomes and lysosomes of various tissues, as well as in the ruffled border of bone-resorbing osteoclasts

  10. microphthalmia transcription factor (show MITF Proteins) regulates Clcn7 and Ostm1 expression in osteoclasts

OSTM1 Protein Profile

Protein Summary

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.

Gene names and symbols associated with OSTM1

  • osteopetrosis associated transmembrane protein 1 (OSTM1)
  • osteopetrosis associated transmembrane protein 1 (ostm1)
  • osteopetrosis associated transmembrane protein 1 (Ostm1)
  • osteopetrosis-associated transmembrane protein 1 (GL)
  • 1200002H13Rik protein
  • Gipn protein
  • gl protein
  • HSPC019 protein
  • MGC145644 protein
  • OPTB5 protein
  • OSTM1 protein
  • si:ch73-257c13.3 protein

Protein level used designations for OSTM1

osteopetrosis-associated transmembrane protein 1 , osteopetrosis associated transmembrane protein 1 , GAIP-interacting protein N terminus , chloride channel 7 beta subunit , grey-lethal osteopetrosis , grey lethal osteopetrosis , GAIP interacting protein N terminus , osteopetrosis associated transmembrane protein 1-like

GENE ID SPECIES
421773 Gallus gallus
518522 Bos taurus
701341 Macaca mulatta
739203 Pan troglodytes
780037 Xenopus (Silurana) tropicalis
100137453 Papio anubis
100320445 Danio rerio
100328697 Oryctolagus cuniculus
28962 Homo sapiens
14628 Mus musculus
499474 Rattus norvegicus
100049681 Sus scrofa
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