OSTM1 Protein (His tag)

Catalog No. ABIN7317722

Product Details

Target: OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This OSTM1 protein is labelled with His tag.

Purpose: Recombinant Human OSTM1 Protein (His Tag)

Sequence: Met 1-Pro 284

Characteristics: A DNA sequence encoding the extracellular domain of human OSTM1 (NP_054747.2) (Met 1-Pro 284) was expressed, fused with a C-terminal polyhistidine tag.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))

Alternative Name: OSTM1 (OSTM1 Products)

Synonyms: MGC145644 Protein, si:ch73-257c13.3 Protein, GIPN Protein, GL Protein, OPTB5 Protein, 1200002H13Rik Protein, HSPC019 Protein, gl Protein, Gipn Protein, OSTM1 Protein, osteopetrosis associated transmembrane protein 1 Protein, OSTM1 Protein, ostm1 Protein, Ostm1 Protein

Background:

Background: Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I  membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).

Synonym: GIPN;GL;HSPC019;OPTB5

Molecular Weight: 29.7 kDa

NCBI Accession: NP_054747