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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Proteins (11) and PDZ Binding Kinase Kits (6) and many more products for this protein.
Showing 10 out of 134 products:
Human Monoclonal PBK Primary Antibody for IF, WB - ABIN968771
Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000
Show all 3 references for ABIN968771
Human Monoclonal PBK Primary Antibody for ICC, FACS - ABIN969345
Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007
Show all 2 references for ABIN969345
Human Polyclonal PBK Primary Antibody for WB - ABIN1881635
Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 2 references for ABIN1881635
Human Polyclonal PBK Primary Antibody for EIA, IHC (p) - ABIN359330
Nandi, Tidwell, Karp, Rapoport: Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. in Blood cells, molecules & diseases 2004
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Cow (Bovine) Polyclonal PBK Primary Antibody for WB - ABIN2783527
Uhl, Liu, Drgon, Johnson, Walther, Rose, David, Niaura, Lerman: Molecular genetics of successful smoking cessation: convergent genome-wide association study results. in Archives of general psychiatry 2008
Overexpression of Nrf2 (show GABPA Antibodies) inhibited the PBK/TOPK KD-induced decrease in cdc2 (show CDK1 Antibodies) and cyclin B expression and cell cycle arrest, and blocked ROS (show ROS1 Antibodies) production and apoptosis.
The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.
TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer
Authors identified TOPK/PBK, in vitro and in vivo, as the master ZFP (show ZNF167 Antibodies) linker kinase. Furthermore, they show precise temporal correlation between TOPK activating phosphorylation by Cdk1 (show CDK1 Antibodies) and linker phosphorylation in mitosis.
PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.
TOPK, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.
PDZ-binding kinase/T-LAK cell-originated protein kinase correlates with mutant p53 (show TP53 Antibodies) and affects cell proliferation and viability as well as prognosis in lung adenocarcinoma
Study findings suggest that the PBK/TOPK mRNA/protein expression is specific to human bladder cancer and might be used as a novel target for development of cancer immunotherapy and diagnostic biomarker.
CHFR (show CHFR Antibodies) ubiquitinates and regulates TOPK levels, which is essential for its checkpoint function.
TOPK protein upregulates iNOS (show NOS2 Antibodies) gene expression in T cell leukemia Jurkat cells or macrophage leukemic Raw 264.7 cells via NF-kappaB (show NFKB1 Antibodies) activation in response to LPS (show IRF6 Antibodies), and might act as a critical effector in LPS/TLR4 (show TLR4 Antibodies)-mediated signaling cascade.
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Antibodies) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Antibodies) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog