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PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. Additionally we are shipping PHF2 Antibodies (35) and many more products for this protein.
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these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation.
PHF2 enhances osteoblast differentiation by demethylating Runx2 (show RUNX2 Proteins), while suppressor of variegation 3-9 homolog 1 (SUV39H1 (show SUV39H1 Proteins)) inhibits bone formation by methylating it.
Arid5b (show ARID5B Proteins) recruits Phf2 to the promoter region of Sox9 (show SOX9 Proteins) target genes and stimulates H3K9me2 demethylation of these genes.
Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha (show CEBPA Proteins)) gene and demethylates histones in chromatin.
histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation
PHF2 (show PHF1 Proteins) acts as a tumor suppressor in association with p53 (show TP53 Proteins) in cancer development and ensures p53 (show TP53 Proteins)-mediated cell death in response to chemotherapy.
PHF2 (show PHF1 Proteins) is likely to repress rDNA transcription by competing with PHF8 (show PHF8 Proteins) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (show SUV39H1 Proteins).
JARID1B (show KDM5B Proteins) and PHF2 (show PHF1 Proteins) are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression
the crystal structures of PHF2 (show PHF1 Proteins) Jumonji (show JARID2 Proteins) domain in the absence and presence of additional exogenous metal ions were determined.
Differential association of alterations in FANCC (show FANCC Proteins) and PTCH1 (show PTCH1 Proteins) with that of PHF2 (show PHF1 Proteins), XPA (show XPA Proteins) and two breast cancer susceptibility genes (BRCA1/BRCA2 (show BRCA2 Proteins)) in the two age groups suggests differences in their molecular pathogenesis.
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
PHD finger protein 2
, polycomb-like protein 1
, t-complex testis-expressed 3
, centromere protein 35
, jumonji C domain-containing histone demethylase 1E
, lysine-specific demethylase PHF2
, PHD finger protein 8
, lysine-specific demethylase phf2