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PTK6 Protein tyrosine Kinase 6 Proteins (PTK6)

The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Additionally we are shipping PTK6 Antibodies (132) and PTK6 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTK6 5753 Q13882
Rat PTK6 PTK6 366275  
PTK6 20459 Q64434
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Top PTK6 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus Human GST-His-Tag Recombinant BRK protein tested by SDS-PAGE gel. 0.5 µg of BRK protein was analyzed using SDS/PAGE followed by Western blot with either an anti-BRK or anti-GST antibody. 10 μg Log in to see 1 to 2 Days
$443.33
Details
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days
$571.07
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PTK6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine) ,
,

More Proteins for PTK6 Protein tyrosine Kinase 6 (PTK6) Interaction Partners

Human PTK6 Protein tyrosine Kinase 6 (PTK6) interaction partners

  1. PELP1 (show PELP1 Proteins) interacted with GR to activate Brk expression.

  2. PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo

  3. BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (show KHDRBS1 Proteins)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.

  4. Additive impact of HER2 (show ERBB2 Proteins)-/PTK6-RNAi on interactions with HER3 (show ERBB3 Proteins) or IGF-1R (show IGF1R Proteins) leads to reduced breast cancer progression

  5. overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17.

  6. Establishment of cross talk between PTK6 and CagA (show S100A8 Proteins) by functional studies may further elucidate the underlying biology of H. pylori-mediated gastric cancer

  7. PTK6 is expressed in the normal human mammary gland, but does not appear to be active and may have kinase-independent functions that are distinct from its cancer promoting activities at the membrane.

  8. Down-regulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.

  9. PTP1B (show PTPN1 Proteins) inhibited BRK by dephosphorylating Tyr (show TYR Proteins)-342, but activated SRC (show SRC Proteins) by antagonizing PAG (show PRDX1 Proteins)-dependent inhibition by CSK (show CSK Proteins).

  10. Activating mutations in BRK in breast cancer may disrupt intramolecular interactions that normally maintain BRK in an autoinhibited conformation.

Mouse (Murine) PTK6 Protein tyrosine Kinase 6 (PTK6) interaction partners

  1. PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo

  2. Ptk6 promotes ERBB2 (show ERBB2 Proteins)-induced mammary gland tumorigenesis in the mouse.

  3. Protein tyrosine kinase 6 has a role in mediating TNFalpha (show TNF Proteins)-induced endothelial barrier dysfunction

  4. Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (show AKT1 Proteins).

  5. expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (show MAPK14 Proteins) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.

  6. a novel function for PTK6 at the plasma membrane

  7. PTK6 promotes STAT3 (show STAT3 Proteins) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (show STAT3 Proteins) activity in mouse colon tumors.

  8. AKT (show AKT1 Proteins) is a direct substrate of PTK6 and AKT (show AKT1 Proteins) tyrosine residues 315 and 326 are phosphorylated by PTK6.

  9. PTK6 associates with nuclear and cytoplasmic beta-catenin (show CTNNB1 Proteins) and inhibits beta-catenin (show CTNNB1 Proteins)- and T-cell factor (TCF (show HNF4A Proteins))-mediated transcription.

  10. The tyrosine kinases Brk/PTK6/Sik, Srm (show SRM Proteins), Frk/Rak/Gtk (show FRK Proteins)/Iyk/Bsk (show EPHA5 Proteins), and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.

PTK6 Protein Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PTK6

  • PTK6 protein tyrosine kinase 6 (PTK6)
  • protein tyrosine kinase 6 (PTK6)
  • protein tyrosine kinase 6 (Ptk6)
  • PTK6 protein tyrosine kinase 6 (Ptk6)
  • BRK protein
  • Sik protein
  • tks protein
  • Tksk protein

Protein level used designations for PTK6

PTK6 protein tyrosine kinase 6 , protein-tyrosine kinase 6-like , breast tumor kinase , protein-tyrosine kinase 6 , protein-tyrosine kinase BRK , tyrosine-protein kinase BRK , protein tyrosine kinase 6 , src-related intestinal kinase , tyrosine kinase identified from skin

GENE ID SPECIES
100060532 Equus caballus
100438236 Pongo abelii
100589028 Nomascus leucogenys
5753 Homo sapiens
366275 Rattus norvegicus
20459 Mus musculus
529814 Bos taurus
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