PTK6 Protein (GST tag,His tag)
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- Target See all PTK6 Proteins
- PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Mouse
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This PTK6 protein is labelled with GST tag,His tag.
- Purpose
- Recombinant Mouse PTK6/Brk Protein (His & GST Tag)(Active)
- Sequence
- Met1-Val451
- Characteristics
- A DNA sequence encoding the mouse PTK6 (Q64434) (Met1-Val451) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Purity
- > 90 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 5 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.
- Top Product
- Discover our top product PTK6 Protein
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PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) (Active) protein (His-GST)
PTK6 Origin: Human Host: Insect cells (Sf9) Recombinant SDS, Func Active
PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 342-451) protein (GST tag)PTK6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) protein (GST tag)PTK6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
PTK6 Protein tyrosine Kinase 6 (PTK6) protein (GST tag)PTK6 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 89 % as determined by reducing SDS-PAGE.
PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) protein (Strep Tag)Crystallography grade PTK6 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) protein (Strep Tag)Crystallography grade PTK6 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
PTK6 Protein tyrosine Kinase 6 (PTK6) (Active) protein (Myc-DYKDDDDK Tag)PTK6 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))
- Alternative Name
- PTK6/Brk (PTK6 Products)
- Synonyms
- BRK Protein, Sik Protein, Tksk Protein, tks Protein, zgc:153964 Protein, protein tyrosine kinase 6 Protein, PTK6 protein tyrosine kinase 6 Protein, PTK6 protein tyrosine kinase 6b Protein, PTK6 Protein, Ptk6 Protein, ptk6b Protein
- Background
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Background: Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.
Synonym: BRK,Sik,tks,Tksk
- Molecular Weight
- 79.8 kDa
- UniProt
- Q64434
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