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anti-PYD and CARD Domain Containing (PYCARD) Antibodies

PYCARD encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). Additionally we are shipping PYCARD Kits (9) and PYCARD Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PYCARD 29108 Q9ULZ3
PYCARD 66824 Q9EPB4
PYCARD 282817  
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Top anti-PYCARD Antibodies at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated EIA, IHC (p), WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Mouse Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184674 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of ASC in HL60 cells with AP30084PU-N ASC antibody at 5 μg/ml. Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide with AP30084PU-N ASC antibody at 1 μg /ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PYCARD Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate WB Suggested Anti-PYCARD  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB PYCARD Antibody (C-term) (ABIN657783) western blot analysis in MCF-7 cell line lysates (35 µg/lane). This demonstrates the PYCARD antibody detected the PYCARD protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

PYCARD Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PYCARD Antibodies

  1. Human Monoclonal PYCARD Primary Antibody for IP, WB - ABIN1105662 : Norlén, Curry, Björkqvist, Maule, Cunningham, Hogg, Harriott, Johnston, Hutton, Håkanson: Cell-specific processing of chromogranin A in endocrine cells of the rat stomach. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001 (PubMed)
    Show all 8 references for ABIN1105662

  2. Human Polyclonal PYCARD Primary Antibody for EIA, IF - ABIN499343 : Masumoto, Taniguchi, Nakayama, Ayukawa, Sagara: Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. in Experimental cell research 2001 (PubMed)
    Show all 5 references for ABIN499343

  3. Human Polyclonal PYCARD Primary Antibody for WB - ABIN610691 : Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 4 references for ABIN610691

  4. Human Polyclonal PYCARD Primary Antibody for IHC, ELISA - ABIN184674 : Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. in Nature cell biology 2004 (PubMed)

  5. Mouse (Murine) Polyclonal PYCARD Primary Antibody for WB - ABIN2780039 : Mariathasan, Newton, Monack, Vucic, French, Lee, Roose-Girma, Erickson, Dixit: Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. in Nature 2004 (PubMed)

More Antibodies against PYCARD Interaction Partners

Human PYD and CARD Domain Containing (PYCARD) interaction partners

  1. The proteins of NLRP3 (show NLRP3 Antibodies), ASC, and caspase-1 (show CASP1 Antibodies) were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

  2. ASC/TMS1 methylation was significantly correlated with higher tumor nuclear grade. ASC/TMS1 is a novel functional tumor suppressor in renal carcinogenesis.

  3. ASC Induces Procaspase-8 Death Effector Domain Filaments

  4. ASC interacts with NALP3 (show NLRP3 Antibodies) and caspase-1 (show CASP1 Antibodies) via different domains.

  5. The proteins (HSP90b (show HSP90AB1 Antibodies), TSM1 and L-plastin (show LCP1 Antibodies)) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.

  6. caspase-1 (show CASP1 Antibodies)/ASC inflammasomes play a significant role in the activation of IL-1beta (show IL1B Antibodies)/ROS (show ROS1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling of cytokine gene expression for T. cruzi control in human and mouse macrophages.

  7. Neutralization of ASC improves sperm motility in men with spinal cord injuries.

  8. Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway (show NLRP3 Antibodies)(NLRP3, PYCARD) in obesity-induced adipose inflammation.

  9. Data indicate that apoptosis-associated speck-like protein containing a caspase (show CASP3 Antibodies) recruitment domain (ASC) is highly expressed in medulloblastomas.

  10. R42W mutation had a significant effect on structure and increased stability. Although the R42W mutant exhibited reduced interaction with ASC

Mouse (Murine) PYD and CARD Domain Containing (PYCARD) interaction partners

  1. Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).

  2. Data suggest that interleukin 22 (IL-22 (show IL22 Antibodies)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (show STS Antibodies))-dependent stimulation of interleukin-1 beta (IL-1beta (show IL1B Antibodies)) production.

  3. report herein that lack of ASC (show STS Antibodies) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (show STS Antibodies)(-/-) mice are capable of producing robust amounts of IL-1beta (show IL1B Antibodies) comparable with C57BL/6 mice

  4. These data identify a novel non-canonical immunoregulatory function of NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in autoimmunity.

  5. a significant role for NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in prion (show PRNP Antibodies) pathogenesis

  6. ASC (show STS Antibodies)-driven caspase-1 (show CASP1 Antibodies) autoprocessing and speck formation are dispensable for the activation of caspase-1 (show CASP1 Antibodies) and the NLRP1b inflammasome.

  7. IKKalpha (show CHUK Antibodies) controls the inflammasome at the level of the adaptor molecule ASC (show STS Antibodies), which interacts with IKKalpha (show CHUK Antibodies) in the nucleus of resting macrophages in an IKKalpha (show CHUK Antibodies) kinase-dependent manner.

  8. Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (show STS Antibodies), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.

  9. gene deficiency results in absence of IL-1beta (show IL1B Antibodies) maturation in the middle ear response to non-typeable Haemophilus influenza, and in reduction of both leukocyte infiltration and macrophage phagocytosis

  10. Data (including data from studies using knockout mice) suggest that Asc is required for macrophage activation and inflammasome-dependent secretion of interleukin 1beta from peritoneal macrophages upon exposure to silica particles.

PYCARD Antigen Profile

Protein Summary

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PYCARD

  • PYD and CARD domain containing (PYCARD) antibody
  • PYD and CARD domain containing (Pycard) antibody
  • PYD and CARD domain containing (pycard) antibody
  • 9130417A21Rik antibody
  • Asc antibody
  • asc1 antibody
  • CARD5 antibody
  • masc antibody
  • TMS antibody
  • TMS-1 antibody
  • TMS1 antibody
  • TNS1 antibody
  • zAsc antibody
  • zgc:109874 antibody

Protein level used designations for PYCARD

apoptosis-associated speck-like protein containing a CARD , caspase recruitment domain-containing protein 5 , target of methylation-induced silencing 1 , PYD and CARD domain-containing protein

GENE ID SPECIES
29108 Homo sapiens
66824 Mus musculus
282817 Rattus norvegicus
282846 Bos taurus
57923 Danio rerio
Selected quality suppliers for anti-PYCARD (PYCARD) Antibodies
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