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PYCARD encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). Additionally we are shipping PYCARD Kits (9) and PYCARD Proteins (8) and many more products for this protein.
Showing 10 out of 106 products:
Human Monoclonal PYCARD Primary Antibody for IP, WB - ABIN1105662
Norlén, Curry, Björkqvist, Maule, Cunningham, Hogg, Harriott, Johnston, Hutton, Håkanson: Cell-specific processing of chromogranin A in endocrine cells of the rat stomach. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001
Show all 8 references for ABIN1105662
Human Polyclonal PYCARD Primary Antibody for EIA, IF - ABIN499343
Masumoto, Taniguchi, Nakayama, Ayukawa, Sagara: Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. in Experimental cell research 2001
Show all 5 references for ABIN499343
Human Polyclonal PYCARD Primary Antibody for WB - ABIN610691
Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995
Show all 4 references for ABIN610691
Human Polyclonal PYCARD Primary Antibody for IHC, ELISA - ABIN184674
Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. in Nature cell biology 2004
Mouse (Murine) Polyclonal PYCARD Primary Antibody for WB - ABIN2780039
Mariathasan, Newton, Monack, Vucic, French, Lee, Roose-Girma, Erickson, Dixit: Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. in Nature 2004
ASC/TMS1 methylation was significantly correlated with higher tumor nuclear grade. ASC/TMS1 is a novel functional tumor suppressor in renal carcinogenesis.
ASC Induces Procaspase-8 Death Effector Domain Filaments
ASC interacts with NALP3 (show NLRP3 Antibodies) and caspase-1 (show CASP1 Antibodies) via different domains.
The proteins (HSP90b (show HSP90AB1 Antibodies), TSM1 and L-plastin (show LCP1 Antibodies)) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.
caspase-1 (show CASP1 Antibodies)/ASC inflammasomes play a significant role in the activation of IL-1beta (show IL1B Antibodies)/ROS (show ROS1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling of cytokine gene expression for T. cruzi control in human and mouse macrophages.
Neutralization of ASC improves sperm motility in men with spinal cord injuries.
Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway (show NLRP3 Antibodies)(NLRP3, PYCARD) in obesity-induced adipose inflammation.
Data indicate that apoptosis-associated speck-like protein containing a caspase (show CASP3 Antibodies) recruitment domain (ASC) is highly expressed in medulloblastomas.
R42W mutation had a significant effect on structure and increased stability. Although the R42W mutant exhibited reduced interaction with ASC
ASC PYD prevented complex formation with NALP3 (show NLRP3 Antibodies) PYD in vitro
Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).
Data suggest that interleukin 22 (IL-22 (show IL22 Antibodies)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (show STS Antibodies))-dependent stimulation of interleukin-1 beta (IL-1beta (show IL1B Antibodies)) production.
report herein that lack of ASC (show STS Antibodies) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (show STS Antibodies)(-/-) mice are capable of producing robust amounts of IL-1beta (show IL1B Antibodies) comparable with C57BL/6 mice
These data identify a novel non-canonical immunoregulatory function of NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in autoimmunity.
a significant role for NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in prion (show PRNP Antibodies) pathogenesis
ASC (show STS Antibodies)-driven caspase-1 (show CASP1 Antibodies) autoprocessing and speck formation are dispensable for the activation of caspase-1 (show CASP1 Antibodies) and the NLRP1b inflammasome.
IKKalpha (show CHUK Antibodies) controls the inflammasome at the level of the adaptor molecule ASC (show STS Antibodies), which interacts with IKKalpha (show CHUK Antibodies) in the nucleus of resting macrophages in an IKKalpha (show CHUK Antibodies) kinase-dependent manner.
Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (show STS Antibodies), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.
gene deficiency results in absence of IL-1beta (show IL1B Antibodies) maturation in the middle ear response to non-typeable Haemophilus influenza, and in reduction of both leukocyte infiltration and macrophage phagocytosis
Data (including data from studies using knockout mice) suggest that Asc is required for macrophage activation and inflammasome-dependent secretion of interleukin 1beta from peritoneal macrophages upon exposure to silica particles.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
apoptosis-associated speck-like protein containing a CARD
, caspase recruitment domain-containing protein 5
, target of methylation-induced silencing 1
, PYD and CARD domain-containing protein