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The protein encoded by PPRC1 is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). Additionally we are shipping PPRC1 Antibodies (27) and and many more products for this protein.
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these results indicated an elevated basal metabolic rate and lipid metabolic alteration of male Pprc1(+/-) mice on high-fat diet, suggesting the significant role of Pprc1 in controlling mitochondrial gene expression and energy metabolic processes
Homozygous deficient PPRC1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for PPRC1 were viable, fertile and indistinguishable from their wild-type littermates.
PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress.
PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB (show NFKB1 ELISA Kits) activity
A general role for PRC in the adaptive response to cellular dysfunction.
PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle
overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma
PGC-1 (show PPARGC1A ELISA Kits) has a role in regulating gluconeogenic genes along with HNF-4alpha (show HNF4A ELISA Kits) and SREBP-1 (show SREBF1 ELISA Kits)
This review focuses on the biologic and physiologic functions of the PGC-1 (show PPARGC1A ELISA Kits) coactivators, with particular emphasis on striated (show NSDHL ELISA Kits) muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
Upregulation of PGC-1alpha (show PPARGC1A ELISA Kits) and PGC-1beta (show PPARGC1B ELISA Kits) in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation.
These results revealed that bile acid inhibits the promoter activity of PGC-1 (show PPARGC1A ELISA Kits) in an SHP (show LAMC1 ELISA Kits)-dependent manner.
Activation of the SIRT1 (show SIRT1 ELISA Kits)/PGC-1 (show PPARGC1A ELISA Kits) pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review.
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
, peroxisome proliferator-activated receptor gamma coactivator-related protein 1
, PGC-1 related co-activator
, peroxisome proliferative activated receptor, gamma, coactivator-related 1