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Catalyzes the transfer of phosphatidylcholine between membranes. Additionally we are shipping PCTP Proteins (8) and PCTP Kits (3) and many more products for this protein.
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Human Polyclonal PCTP Primary Antibody for EIA, WB - ABIN954056
Roderick, Chan, Agate, Olsen, Vetting, Rajashankar, Cohen: Structure of human phosphatidylcholine transfer protein in complex with its ligand. in Nature structural biology 2002
Show all 4 references for ABIN954056
PC-TP contributes to the racial difference in PAR4 (show PAWR Antibodies)-mediated platelet activation.
crystal structures of human PC-TP in complex with dilinoleoyl-PtdCho or palmitoyl-linoleoyl-PtdCho reveal that a single well-ordered PtdCho molecule occupies a centrally located tunnel
phosphatidylcholine transfer protein gene variants are associated with LDL-peak particle size
Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2 (show ACOT13 Antibodies)) and the homeodomain transcription factor Pax3 (paired box gene 3 (show PAX3 Antibodies)), respectively, as PC-TP-interacting proteins.
Them2 (show ACOT13 Antibodies) and phosphatidylcholine transfer protein regulate lipid and glucose metabolism
PC-TP-THEM2 (show ACOT13 Antibodies) complex reduces phosphorylation and stability of IRS2 (show IRS2 Antibodies) and increases stability of the TSC1 (show TSC1 Antibodies)-TSC2 (show TSC2 Antibodies) complex
Findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT (show BAAT Antibodies).
regulation of cholesterol homeostasis is a physiological function of PC-TP in liver, which can be overcome with a cholesterol-rich lithogenic diet
In Pctp(-/-) mice, there was an accumulation of small alpha-migrating HDL (show HSD11B1 Antibodies) particles. PC-TP participates in HDL (show HSD11B1 Antibodies) reverse cholesterol transport.
PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations
NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains.
data support a key biological role for PCTP in the regulation of energy substrate utilization, reflecting increased hepatic triglyceride production in knockout mice.
Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.
START domain-containing protein 2
, StAR-related lipid transfer (START) domain containing 2
, stAR-related lipid transfer protein 2