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integral membrane protein associated with vesicles\; protein highly expressed in the caveolae in lung epithelium [RGD, Feb 2006].. Additionally we are shipping PLVAP Antibodies (64) and PLVAP Kits (14) and many more products for this protein.
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an endothelium-specific molecule, plasmalemma vesicle-associated protein (PLVAP), regulates the seeding of fetal monocyte-derived macrophages to tissues in mice
Results indicate that PLVAP is not only required for the formation of endothelial diaphragms, but also for the formation of endothelial fenestrae, even of those without diaphragms.
In the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens.
PV1 is involved in the tumor angiogenesis
formation of diaphragms is the only role of PV1
upregulation of microvascular expression of PV-1 post-spinal cord injury may promote major components of secondary injury
The PV-1 protein is negatively regulated in pulmonary endothelial cells by VEGF-R2 signaling.
Compelling evidence for a functional role of PV-1 in the formation of large transendothelial channels and modulation of nuclear shape.
PV-1 is necessary for fenestral pore architecture and the ordered arrangement of fenestrae in sieve plates.
The molecule recognized by PAL-E and anti-PV-1 antibodies is not NRP-1 but PV-1.
These results suggest that PV1 protein is able to block SV40 infectivity at low but not at high viral concentration either by interfering with the infective internalization pathway at the cell surface or at a post internalization step.
Case Report: Suggest activated platelets, enhanced coagulation state, glomerular expression of PV-1 and endothelial damage may contribute to glomerulonephropathy associated with polycythemia vera (show IGF2BP3 Proteins).
PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms.
leukocyte transendothelial migration is the first known function for PV-1
integral membrane protein associated with vesicles\; protein highly expressed in the caveolae in lung epithelium
, plasmalemma vesicle protein 1
, plasmalemma vesicle-associated protein
, fenestrated endothelial-linked structure protein
, fenestrated-endothelial linked structure protein; PV-1 protein