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anti-Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) Antibodies

This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. Additionally we are shipping Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Proteins (17) and Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PAFAH1B1 83572 P63004
PAFAH1B1 5048 P43034
PAFAH1B1 18472 P63005
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Top anti-Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PAFAH1B1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN184751 staining (2µg/ml) of NIH-3T3 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of LIS1 in Jurkat cells with this product at 2.5 μg/ml. Western blot analysis of LIS1 in HeLa cell lysate AP30511PU-N at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Cow Goat Un-conjugated EIA, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PAFAH1B1at 3.75 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Pancreas (formalin-fixed, paraffin-embedded) stained with PAFAH1B1at 3.75 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Thymus (formalin-fixed, paraffin-embedded) stained with PAFAH1B1 antibody ABIN213960 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged PAFAH1B1 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PAFAH1B1 antibody ABIN364420 at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Human Thyroid (formalin-fixed, paraffin-embedded) stained with PAFAH1B1 antibody ABIN364420 at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

PAFAH1B1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Antibodies

  1. Human Polyclonal PAFAH1B1 Primary Antibody for EIA, IF - ABIN500180 : Hattori, Adachi, Tsujimoto, Arai, Inoue: Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. in Nature 1994 (PubMed)
    Show all 4 references for ABIN500180

  2. Chicken Polyclonal PAFAH1B1 Primary Antibody for WB - ABIN2786517 : Campo, Sardo, Trimarchi, Bonaiuto, Saitta, Bitto, Castaldo, Cinquegrani, Bonaiuto, Cristadoro, Saitta: Platelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians. in Aging clinical and experimental research 2008 (PubMed)

  3. Cow (Bovine) Polyclonal PAFAH1B1 Primary Antibody for WB - ABIN374217 : Reiner, Bar-Am, Sapir, Shmueli, Carrozzo, Lindsay, Baldini, Ledbetter, Cahana: LIS2, gene and pseudogene, homologous to LIS1 (lissencephaly 1), located on the short and long arms of chromosome 2. in Genomics 1996 (PubMed)

More Antibodies against Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Interaction Partners

Human Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

  1. Results showed that miR (show MLXIP Antibodies)-144 was reduced in cholangiocarcinoma tissues and suggested that miR (show MLXIP Antibodies)-144 may be an essential suppresser of cholangiocarcinoma cell proliferation and invasion through targeting LIS1.

  2. LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.

  3. Identify a key role for Lis1 in hematopoietic stem cells and mark its directed control of asymmetric division as a critical regulator of normal and malignant hematopoietic development

  4. LIS1 gene duplication is associated with developmental, behavioral and brain abnormalities.

  5. LIS1 is required for dynein-mediated transport induced by membrane tethering of BICD2 (show BICD2 Antibodies)-N and LIS1 contributes to dynein accumulation at microtubule plus ends and BICD2 (show BICD2 Antibodies)-positive cellular structures.

  6. PAFAH1B1 overexpression contributes to lung tumorigenesis and poor prognosis.

  7. Studies identified three genes, CHD5 (show WRB Antibodies), PAFAH1B1, and NME1 (show NME1 Antibodies), strongly associated with patient outcome.

  8. Studies indicate that binding of dynactin (show DCTN1 Antibodies), LIS1 and NudEL (show NDEL1 Antibodies) regulate cytoplasmic dynein (show DYNC1H1 Antibodies) motor activity.

  9. The results did not detect a significant association. It indicated that common genetic variations in LIS1 genes might not play a role in the genetic predisposition to autism.

  10. cell type-restricted role for LIS1 in large vesicular transport and quantitative support for a general role for LIS1 in high-load dynein functions.

Xenopus laevis Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

  1. Nudel (show NDEL1 Antibodies)/NudE and Lis1 promote dynein and dynactin (show DCTN1 Antibodies) interaction in the context of spindle morphogenesis.

  2. Full rescue by the coiled-coil domain requires LIS1 binding, and increasing LIS1 concentration partly rescues aster formation

Cow (Bovine) Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

  1. PAFAH Ib phospholipase A2 (show YWHAZ Antibodies) subunits have distinct roles in maintaining Golgi structure and function.

  2. Results suggest that LIS1 is essential to mediate genomic union in a process that involves the dynein-dynactin (show DCTN1 Antibodies) complex.

Mouse (Murine) Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

  1. This study demonstrated that LIS-1 regulate the septohippocampal cholinergic projection developmental.

  2. Lis1 is required for the expansion of FL-HSCs by ensuring their genomic stability and therefore promoting their survival.

  3. Results show that LIS1 acts via the LIS1-NDEL1 (show NDEL1 Antibodies)-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs (show NEU2 Antibodies) with the cell cortex to ensure precise cell division.

  4. Conditional deletion of Lis1 in the hematopoietic system led to a severe bloodless phenotype, depletion of the stem cell pool and embryonic lethality.

  5. Rab6a mediates LIS1 release from a LIS1-dynein complex followed by dynein activation.

  6. LIS1 plays prominently in filopodia dynamics and dendritic spine turnover.

  7. Nde1 and Lis1 regulate central nervous system development by interpreting midline signals differentially.

  8. Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.

  9. Lis1 is required for the dorsally directed tangential migration of many sympathetic and parasympathetic preganglionic neurons and a subset of somatic motor neurons.

  10. findings indicate that disruption of LIS1 has direct effects on excitatory synaptic transmission independent of laminar disorganization.

Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) Antigen Profile

Protein Summary

This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.

Gene names and symbols associated with PAFAH1B1

  • platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (Pafah1b1) antibody
  • platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) (PAFAH1B1) antibody
  • platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) (pafah1b1) antibody
  • platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 (Pafah1b1) antibody
  • LIS-1 antibody
  • Lis1 antibody
  • lis2 antibody
  • mdcr antibody
  • mds antibody
  • Mdsh antibody
  • MMS10-U antibody
  • Ms10u antibody
  • pafah antibody
  • pafah1b1-b antibody
  • Pafaha antibody

Protein level used designations for PAFAH1B1

LIS-1 , PAF acetylhydrolase 45 kDa subunit , PAF-AH 45 kDa subunit , PAF-AH alpha , PAF-AH beta , PAFAH alpha , lissencephaly-1 protein , platelet-activating factor acetylhydrolase IB subunit alpha , platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta) , platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 , platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa , lissencephaly 1 protein , platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD) , platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) , chLIS1 , lissencephaly-1 homolog , LIS1 , lissencephaly-1 homolog B , platelet-activating factor acetylhydrolase Ib-alpha subunit , Miller-Dieker syndrome chromosome region , Lissencephaly-1 protein , platelet-activating factor acetylhydrolase isoform Ib alpha subunit , platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 , platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit

GENE ID SPECIES
83572 Rattus norvegicus
5048 Homo sapiens
374224 Gallus gallus
399199 Xenopus laevis
397482 Sus scrofa
282513 Bos taurus
480656 Canis lupus familiaris
100135766 Felis catus
454422 Pan troglodytes
18472 Mus musculus
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