PAFAH1B1 antibody (AA 40-155)

Catalog No. ABIN7163601

Product Details anti-PAFAH1B1 Antibody

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Binding Specificity: AA 40-155

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAFAH1B1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Platelet-activating factor acetylhydrolase IB subunit alpha protein (40-155AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAFAH1B1

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Alternative Name: PAFAH1B1 (PAFAH1B1 Products)

Synonyms: LIS1 antibody, LIS2 antibody, MDCR antibody, MDS antibody, PAFAH antibody, LIS-1 antibody, Lis1 antibody, MMS10-U antibody, Mdsh antibody, Ms10u antibody, Pafaha antibody, lis2 antibody, mdcr antibody, mds antibody, pafah antibody, pafah1b1-b antibody, PAFAHA antibody, Lis1a antibody, platelet activating factor acetylhydrolase 1b regulatory subunit 1 antibody, platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 antibody, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 antibody, platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog antibody, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a antibody, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b antibody, PAFAH1B1 antibody, Pafah1b1 antibody, pafah1b1.L antibody, pafah1b1a antibody, pafah1b1b antibody

Background:

Background: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Aliases: LIS 1 antibody, LIS 2 antibody, LIS-1 antibody, LIS1 antibody, LIS1_HUMAN antibody, LIS2 antibody, Lissencephaly 1 protein antibody, Lissencephaly-1 protein antibody, MDCR antibody, MDS antibody, PAF acetylhydrolase 45 kDa subunit antibody, PAF AH 45 kDa subunit antibody, PAF AH alpha antibody, PAF-AH 45 kDa subunit antibody, PAF-AH alpha antibody, PAFAH alpha antibody, PAFAH antibody, PAFAH1B1 antibody, PAFAHA antibody, Platelet activating factor acetylhydrolase 1b regulatory subunit 1 antibody, Platelet activating factor acetylhydrolase isoform Ib alpha subunit antibody, Platelet-activating factor acetylhydrolase IB subunit alpha antibody

UniProt: P43034

Pathways: M Phase, Regulation of Cell Size