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May be a transforming oncogene with exchange activity for CDC42. Additionally we are shipping PLEKHG2 Proteins (3) and many more products for this protein.
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Human Polyclonal PLEKHG2 Primary Antibody for WB - ABIN611223
Moro, Sirrenberg, Schneider, Neupert, Brunner: The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. in The EMBO journal 1999
Show all 3 references for ABIN611223
Autoantibodies binding to Plekhg2 were found in 19 of 29 patients (66%) with active mycobacterial infections.
The tyrosine phosphorylation of PLEKHG2 plays an important role in EphB2 (show EPHB2 Antibodies) signaling, which is closely related to cell growth and the proliferation of tumor.
results provide evidence that stimulation of the Ras/MAPK (show MAPK1 Antibodies) pathway by EGFR (show EGFR Antibodies) results in FLJ00018 phosphorylation at Thr (show TRH Antibodies)-680, which in turn controls changes in cell shape.
PLEKHG2 may serve as a key Gbeta-gamma-stimulated RhoGEF that regulates lymphocyte chemotaxis via Rac and Cdc42 activation and actin polymerization.
These results suggest that FLJ00018 is targeted via its pleckstrin (show PLEK Antibodies) homology domain to cellular membranes.
The binding of Rho family specific guanine nucleotide exchange factor(FLJ00018), at least two actin binding regions of FLJ00018, and actin negatively regulates for FLJ00018 function.
Activation of clg (show MMP1 Antibodies), a novel dbl (show MCF2 Antibodies) family guanine nucleotide exchange factor (show RASGRF1 Antibodies) gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias
signaling pathway by which G(i)-coupled receptor specifically induces Rac (show AKT1 Antibodies) and Cdc42 (show CDC42 Antibodies) activation through direct interaction of Gbetagamma with FLJ00018.
May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity).
PH domain-containing family G member 2
, common-site lymphoma/leukemia guanine nucleotide exchange factor
, pleckstrin homology domain-containing family G member 2
, common site lymphoma/leukemia GEF
, common site lymphoma/leukemia guanine nucleotide exchange factor
, common-site lymphoma/leukemia GEF