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Polymeric Immunoglobulin Receptor Proteins (PIGR)

PIGR is a member of the immunoglobulin superfamily. Additionally we are shipping PIGR Antibodies (135) and PIGR Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIGR 25046 P15083
PIGR 5284 P01833
PIGR 18703 O70570
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Top PIGR Proteins at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 11 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Cow His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Cow His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PIGR Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,

Human , , , , , , ,
, , ,
Mouse (Murine) , ,
,

Top referenced PIGR Proteins

  1. Human PIGR Protein expressed in HEK-293 Cells - ABIN2181649 : Hamburger, West, Bjorkman: Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. in Structure (London, England : 1993) 2004 (PubMed)
    Show all 4 references for ABIN2181649

  2. Human PIGR Protein expressed in Human Cells - ABIN2002142 : Kaetzel: Polymeric Ig receptor: defender of the fort or Trojan horse? in Current biology : CB 2001 (PubMed)

More Proteins for Polymeric Immunoglobulin Receptor (PIGR) Interaction Partners

Rhesus Monkey Polymeric Immunoglobulin Receptor (PIGR) interaction partners

  1. Both pIgR and FcRn mRNA levels were significantly reduced in the duodenal mucosa during acute SHIV infection and in the jejunum and caecum during chronic SHIV/SIV infection.

Human Polymeric Immunoglobulin Receptor (PIGR) interaction partners

  1. Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis.

  2. Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa.

  3. These results demonstrate that SLPI (show SLPI Proteins) down-regulates pIgR expression through the NF-kappaB (show NFKB1 Proteins) signaling pathway by inhibiting degradation of IkappaBbeta (show NFKBIB Proteins) protein.

  4. Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases.

  5. the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 (show STAT6 Proteins) pathway activation.

  6. Positive expression of pIgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis.

  7. In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway.

  8. Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma.

  9. High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract

  10. pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta (show TGFB1 Proteins)-driven reprogramming of bronchial epithelium.

Cow (Bovine) Polymeric Immunoglobulin Receptor (PIGR) interaction partners

  1. This study evaluated the production of polymeric immunoglobulin receptor and immunoglobulin A in the salivary glands of cattle.

Mouse (Murine) Polymeric Immunoglobulin Receptor (PIGR) interaction partners

  1. pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.

  2. Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.

  3. the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 (show STAT6 Proteins) pathway activation.

  4. In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88 (show MYD88 Proteins).

  5. pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.

  6. Results reveal a novel Yes-EGFR (show EGFR Proteins)-ERK (show EPHB2 Proteins)-FIP5 signalling network for regulation of pIgA (show PIGA Proteins)-pIgR transcytosis.

  7. Blockade of transepithelial transport of dimeric IgA in pIgR knockout mice reduces the degree of protection or cross-protection against viral infection, in parallel with a marked increase in serum IgA concentration and decrease in nasal IgA concentration.

  8. Mice deficient in SIgA have been generated by knocking out the pIgR and assessing their ability to maintain normal mucosal homeostasis and to induce mucosal and systemic immune responses against pathogenic and nonpathogenic stimuli.

  9. Mice that lack expression of the polymeric immunoglobulin receptor have approximately 5-fold more systemic IgA and 6-fold less nasal IgA antibodies than wild-type mice due to defective IgA transport into mucosal tissues.

  10. Data suggest that the pIgR and/or the secretory component are important for the maintenance of epithelial integrity and mucosal homeostasis in the colonic epithelium.

PIGR Protein Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells\; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.

Gene names and symbols associated with PIGR

  • polymeric immunoglobulin receptor (PIGR)
  • polymeric immunoglobulin receptor (Pigr)
  • DKFZp469G1013 protein
  • pIgA-R protein
  • RNPIGR2 protein

Protein level used designations for PIGR

polymeric immunoglobulin receptor , polymeric immunoglobulin receptor-like , poly-Ig receptor , polymeric IgA receptor , hepatocellular carcinoma associated protein TB6 , hepatocellular carcinoma-associated protein TB6 , phosphatidylinositol glycan, class R , poly-IG receptor

GENE ID SPECIES
419848 Gallus gallus
457685 Pan troglodytes
694638 Macaca mulatta
100144764 Ovis aries
100171980 Pongo abelii
100387936 Callithrix jacchus
100583528 Nomascus leucogenys
25046 Rattus norvegicus
5284 Homo sapiens
474357 Canis lupus familiaris
281401 Bos taurus
18703 Mus musculus
397315 Sus scrofa
100328593 Oryctolagus cuniculus
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