anti-Potassium Channel, Subfamily T, Member 1 (KCNT1) Antibodies

Na(+)-activated potassium channel; may be involved in regulating the firing properties of neurons. Additionally we are shipping Potassium Channel, Subfamily T, Member 1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNT1 57582 Q5JUK3
KCNT1 227632 Q6ZPR4
KCNT1 60444 Q9Z258
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Top anti-Potassium Channel, Subfamily T, Member 1 Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Kcnt1 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Mouse Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, WB Slack Rat Brain Membrane Western Blotting. 100 μg Log in to see 2 to 3 Days
$383.90
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KCNT1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse HRP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Human Mouse PE AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$432.30
Details
Human Mouse Streptavidin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$433.40
Details
Human Mouse APC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details

KCNT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Potassium Channel, Subfamily T, Member 1 Antibodies

  1. Mammalian Monoclonal KCNT1 Primary Antibody for ISt, IHC - ABIN1304961 : Lu, Bausch, Kallenborn-Gerhardt, Stoetzer, Debruin, Ruth, Geisslinger, Leffler, Lukowski, Schmidtko: Slack channels expressed in sensory neurons control neuropathic pain in mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 7 Pubmed References

More Antibodies against Potassium Channel, Subfamily T, Member 1 Interaction Partners

Human Potassium Channel, Subfamily T, Member 1 (KCNT1) interaction partners

  1. In the present study, we evaluated two other potential mechanisms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 alpha-helical segments.

  2. two de novo, heterozygous KCNT1 mutations were identified in two unrelated malignant migrating partial seizures probands. Both mutations induced a marked leftward shift in homomeric channel activation gating.

  3. Better understanding of the mechanisms underlying KCNT1-related disease will produce further improvements in treatment of the associated severe seizure disorders.

  4. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than nocturnal frontal lobe epilepsy and malignant migrating focal seizures of infancy.

  5. This study demonstrate that KCNT1 mutations are strongly associated with early-onset epileptic encephalopathy.

  6. Five de novo mutations were identified in four genes (SCNN1A (show SCNN1A Antibodies), KCNJ16 (show KCNJ16 Antibodies), KCNB2 (show KCNB2 Antibodies), and KCNT1) in three Brugada syndrome patients (20%)

  7. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel (show KCNC4 Antibodies) give rise to three distinct forms of epilepsy.

  8. Slick (show KCNT2 Antibodies) channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.

  9. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ (show PIGQ Antibodies).

  10. Novel variations in KCNT1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI).

Mouse (Murine) Potassium Channel, Subfamily T, Member 1 (KCNT1) interaction partners

  1. The highest Slack channel expression was detected in the olfactory bulb, lateral septal nuclei, basal ganglia, and distinct areas of the midbrain, brainstem, and cerebellar cortex.

  2. The authors find that knockout of Slo2.2, but not Slo2.1, results in enhanced itch and pain responses.

  3. Results provide evidence for a role for endogenous Slack channels in higher brain functions, i.e., learning and memory, cognitive flexibility, locomotoric and the ability to initially respond to novel situations and environments

  4. Global ablation of Slack led to increased hypersensitivity in models of neuropathic pain. Neuropathic pain behaviors were also exaggerated after ablation of Slack selectively in sensory neurons.

  5. partly colocalized with PSD-95 (show DLG4 Antibodies) in mouse neocortical neurons

  6. This is the first demonstration of an epithelial cell membrane, Na+-activated, large-conductance K+ channel (show KCNC4 Antibodies) resembling K(Na) channels of excitable cells. The Slo2.2 type, Na+- and Cl--activated K+ channel (show KCNC4 Antibodies) is located in the ascending limb of the kidney.

  7. Slick (show KCNT2 Antibodies) and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.

Potassium Channel, Subfamily T, Member 1 (KCNT1) Antigen Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KCNT1

  • potassium channel, subfamily T, member 1 (KCNT1) antibody
  • potassium channel, subfamily T, member 1 (kcnt1) antibody
  • potassium channel, subfamily T, member 1 (Kcnt1) antibody
  • bA100C15.2 antibody
  • C030030G16Rik antibody
  • EIEE14 antibody
  • ENFL5 antibody
  • KCa4.1 antibody
  • MGC146594 antibody
  • MGC172997 antibody
  • mKIAA1422 antibody
  • rSlo2 antibody
  • Slack antibody
  • slo2 antibody
  • Slo2.2 antibody

Protein level used designations for KCNT1

potassium channel, subfamily T, member 1 , potassium channel subfamily T member 1-like , potassium channel subfamily T member 1 , sodium-activated potassium channel , potassium channel subunit (Slack) , sequence like a calcium-activated potassium channel subunit , potassium channel subunit

GENE ID SPECIES
100436526 Pongo abelii
100588032 Nomascus leucogenys
464846 Pan troglodytes
491258 Canis lupus familiaris
529468 Bos taurus
779818 Xenopus (Silurana) tropicalis
100016518 Monodelphis domestica
100316919 Xenopus (Silurana) tropicalis
57582 Homo sapiens
227632 Mus musculus
60444 Rattus norvegicus
395248 Gallus gallus
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