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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Proteins (KCNJ1)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Antibodies (80) and Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNJ1 3758 P48048
Rat KCNJ1 KCNJ1 24521 P35560
KCNJ1 56379 O88335
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Top Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

KCNJ1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaction Partners

Cow (Bovine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. The findings support ROMK as the pore-forming subunit of the cytoprotective mitoK(ATP) channel in heart mitochondria.

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. WNK4 (show WNK4 Proteins) is a substrate of SFKs and the association of c-Src (show SRC Proteins) and PTP-1D (show PTPN11 Proteins) with WNK4 (show WNK4 Proteins) at Tyr (show TYR Proteins)(1092) and Tyr (show TYR Proteins)(1143) plays an important role in modulating the inhibitory effect of WNK4 (show WNK4 Proteins) on ROMK

  2. knockdown of KCNJ1 in HK-2 (show HK2 Proteins) cells promoted cell proliferation. Collectively, these data highlight that KCNJ1, low-expressed in ccRCC and associated with poor prognosis, plays an important role in ccRCC cell growth and metastasis

  3. The association between polymorphisms in KCNJ1, SLC12A1 (show SLC12A1 Proteins), and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  4. A KCNJ1 SNP was associated with increased FG during HCTZ treatment.

  5. Molecular analysis revealed a compound heterozygous mutation in the KCNJ1 gene, consisting of a novel K76E and an already described V315G mutation, both affecting functional domains of the channel protein.

  6. Findings suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene.

  7. no mutation in the KCNJ1 gene, among patients suffering from bartter and Gitelman syndromes

  8. PI3K (show PIK3CA Proteins)-activating hormones inhibit ROMK by enhancing its endocytosis via a mechanism that involves phosphorylation of WNK1 (show WNK1 Proteins) by Akt1 (show AKT1 Proteins) and SGK1 (show SGK1 Proteins).

  9. THGP (show UMOD Proteins) modulation of ROMK function confers a new role of THGP (show UMOD Proteins) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (show UMOD Proteins)/GCKD patients.

  10. KCNJ1 mutations are associated with Bartter syndrome.

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. Suggest that the hyperkalemia in knock-in mouse with the CUL3 (show CUL3 Proteins)(Delta403-459) mutation is not caused by reduced ROMK expression in the distal nephron.

  2. animal knockouts of ROMK1 do not produce Bartter phenotype. ROMK1 is critical in response to high K intake-stimulated K+ secretion in the collecting tubule.

  3. Lovastatin stimulates ROMK1 channels by inducing PI(4,5)P2 synthesis, suggesting that the drug could reduce cyclosporine-induced nephropathy.

  4. ROMK1 protein abundance and activity are down-regulated by SPAK (show STK39 Proteins) and OSR1 (show OSR1 Proteins)

  5. It was concluded that miR-194 regulates ROMK channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.

  6. THGP (show UMOD Proteins) modulation of ROMK function confers a new role of THGP (show UMOD Proteins) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (show UMOD Proteins)/GCKD patients.

  7. hypertension resistance sequence variants inhibit ROMK channel function by different mechanisms

  8. Absence of small conductance K+ channel (show KCNC4 Proteins) (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in knockout mice a model for bartter's disease__

  9. SGK-1 (show SGK1 Proteins) phosphorylation of ROMK drives expression on the plasmalemma; because SGK-1 (show SGK1 Proteins) is an early aldosterone-induced gene, results suggest a possible molecular mechanism for aldosterone-dependent regulation of the secretory potassium channel (show KCNAB2 Proteins) in the kidney

  10. ROMK is required for functional expression of the 70-pS K channel (show KCNC4 Proteins) in the thick ascending limb.

Zebrafish Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. Kcnj1 is expressed in cells associated with osmoregulation and acts as a K+ efflux pathway that is important in maintaining extracellular levels of potassium ion in the developing embryo.

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Protein Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNJ1

  • potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1)
  • potassium inwardly-rectifying channel, subfamily J, member 1 (kcnj1)
  • potassium inwardly-rectifying channel, subfamily J, member 15 (kcnj15)
  • potassium inwardly-rectifying channel, subfamily J, member 1 (Kcnj1)
  • potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1 (kcnj1a.1)
  • Kcnj protein
  • kcnj1 protein
  • kir1.1 protein
  • MGC68935 protein
  • ROMK protein
  • romk1 protein
  • Romk2 protein
  • wu:fl37c05 protein
  • zgc:63534 protein

Protein level used designations for KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1 , spliced potassium channels ROM-K1, ROM-K2, ROM-K3, ROM-K4, ROM-K5 and ROM-K6 , potassium inwardly-rectifying channel J1 , ATP-sensitive inward rectifier potassium channel 1 , ATP-sensitive inward rectifier potassium channel 1-like , potassium inwardly-rectifying channel, subfamily J, member 15 , ATP-regulated potassium channel ROM-K , inward rectifier K(+) channel Kir1.1 , inwardly rectifying K+ channel , potassium channel, inwardly rectifying subfamily J member 1 , K+ channel protein , KAB-1 , Potassium inwardly-rectifying channel subfamily J , kir1.1 , inwardly rectifying potassium channel ROMK-2

GENE ID SPECIES
281882 Bos taurus
428236 Gallus gallus
466846 Pan troglodytes
539250 Bos taurus
714848 Macaca mulatta
100072580 Equus caballus
100173141 Pongo abelii
100470569 Ailuropoda melanoleuca
100487609 Xenopus (Silurana) tropicalis
100517668 Sus scrofa
100556003 Anolis carolinensis
100579741 Nomascus leucogenys
379692 Xenopus laevis
3758 Homo sapiens
24521 Rattus norvegicus
56379 Mus musculus
447262 Xenopus laevis
489285 Canis lupus familiaris
386933 Danio rerio
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