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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Proteins (6) and Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Kits (1) and many more products for this protein.
Showing 10 out of 55 products:
Mammalian Monoclonal KCND3 Primary Antibody for ISt, IHC - ABIN1304772
Duarri, Lin, Fokkens, Meijer, Smeets, Nibbeling, Boddeke, Sinke, Kampinga, Papazian, Verbeek: Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. in Cellular and molecular life sciences : CMLS 2015
Show all 46 Pubmed References
In ERaKO but not ERaKO mice, the mRNA of Kv4.3 was selectively increased... E2 negatively regulates the density of Ito through ERa, this highlights a potential role for this female hormone in modulating cardiac electrical activity.
Data show that potassium channel (show KCNAB2 Antibodies) Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 (show KCND2 Antibodies) gene (Kv4.2 (show KCND2 Antibodies)-/-).
The gain-of-function SCNA overexpressing dopamine substantia nigra neurons was in part mediated by an increase of their intrinsic pacemaker frequency caused by a redox-dependent impairment of Kv4.3
The protein levels of KV4.3 and KV2.2 (show KCNB2 Antibodies) were up-regulated in the hypertrophic smooth muscle cell membrane.
The experiments here demonstrate that Kv4.2 (show KCND2 Antibodies), Kv4.3 and Kv1.4 (show KCNA4 Antibodies) all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.
Taken together, these data suggest that nerve injury causes an epigenetic silencing of K(v)4.3 gene mediated through transcriptional suppressor NRSF in the DRG.
Kv4.3 channel alpha-subunit (show POLG Antibodies) is found to be one of the components (along with Kv4.2 (show KCND2 Antibodies) and Kv1.4 (show KCNA4 Antibodies)) that propagates the voltage-gated potassium current in pyramidal cortical neurons.
Ativation of AT1 (show SLC33A1 Antibodies) receptors by Angioteinsin II or stretch specifically destabilizes cardiac myocyte Kv4.3 channel mRNA by activating NADPH oxidase (show NOX1 Antibodies).
The results show that Kv4.3 is concentrated in layer 1, the bottom of layer 2/3, and in layers 4 and 5/6.
The results presented here suggest that, in contrast with Kv4.2 (show KCND2 Antibodies), Kv4.3 is not required for the generation of functional mouse ventricular I(to,f) channels.
mutations cause a gainoffunction of KV4.3/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation.
Altered Kv4.3 channel localization and/or functioning resulting from SCA19/22 mutations may lead to Purkinje cell loss, neurodegeneration and ataxia.
the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials.
Kv4.3 K(+) channel (show KCNC4 Antibodies) is involved in heart hypertrophy/heart failure independently of its electric function.[review]
Demonstrate SEMA3A (show SEMA3A Antibodies) as a naturally occurring protein that selectively inhibits Kv4.3 and SEMA3A (show SEMA3A Antibodies) as a possible Brugada syndrome susceptibility gene through a Kv4.3 gain-of-function mechanism.
maps to chromosome 1p21-q21 and identification in Dutch autosomal dominant cerebellar ataxia family
These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13 (show KCNG1 Antibodies), located in the alpha-helix of the toxin, for current blockage.
findings indicate mutations in KCND3 are not a common cause of disease among rarer types of European cerebellar ataxia; however 2 variants were identified in the SCA cases: p.L450F and p.P614S; mutations in KCND3 can cause 2 allelic disorders, SCA19/22 and Brugada syndrome which may co-occur
Report a KV4.3 gain-of-function mutation in early-onset persistent lone atrial fibrillation.
expression of the sodium (SCN5A (show SCN5A Antibodies)) and potassium (KCND3) channels as well as the fibrosis content in the ventricles of heart failure and of non-diseased hearts under different post-mortem intervals
biophysical 11-state Markov model of Kv4.3 gating incorporating a direct transition from the open-inactivated state to the closed-inactivated state
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC Antibodies) in Kv4.3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.
potassium voltage-gated channel, Shal-related subfamily, member 3
, potassium voltage-gated channel subfamily D member 3-like
, potassium voltage-gated channel subfamily D member 3
, potassium voltage-gated channel, Shal-related family, member 3
, potassium channel Kv4.3
, potassium voltage-gated channel Shal-related subfamily member 3
, potassium channel Kv4.3L
, potassium channel Kv4.3M
, voltage-gated potassium channel subunit Kv4.3
, potassium ionic channel Kv4.3
, sha1-related potassium channel Kv4.3
, voltage-gated K+ channel
, potassium voltage gated channel, Shal-related family, member 3