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Pre-B Lymphocyte 1 Proteins (VPREB1)

The protein encoded by VPREB1 belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. Additionally we are shipping Pre-B Lymphocyte 1 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VPREB1 7441 P12018
Rat VPREB1 VPREB1 303782  
Mouse VPREB1 VPREB1 22362 P13372
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Top Pre-B Lymphocyte 1 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

VPREB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Pre-B Lymphocyte 1 (VPREB1) Interaction Partners

Human Pre-B Lymphocyte 1 (VPREB1) interaction partners

  1. VPREB1 focal deletions are common in B-ALL and occur independent of V(D)J light chain recombination. Focal deletions of VPREB1 correlate with decreased expression levels and high-risk patients with focal deletions tend to have poorer overall survival

  2. The proportion of the individuals with <2 copies of the VPREB1 gene was significantly higher in the patient group than that in the controls, while that of the individuals with >2 copies was lower in the patient group than that in the controls.

  3. The 5' region of the VpreB gene contains a promoter which displays higher relative activity in preB (show PREB Proteins) cells compared with cells at other stages or from other lineages.

  4. Pre-B cell integrins and their stromal cell ligands together with the pre-B cell receptor and galectin-1 (show LGALS1 Proteins) form a homogeneous lattice at the contact area between bone marrow pre-B and stromal cells.

Mouse (Murine) Pre-B Lymphocyte 1 (VPREB1) interaction partners

  1. Data show no autoantibody production was detectable in surrogate light chain (SLC (show CCL21A Proteins)) components VpreB/CD179a and lambda5/CD179b (show IGLL1 Proteins) transgenic mice.

  2. VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.

  3. Mice triply deficient for VpreB1 show B cell developmental defects but functional allelic exclusion of the IgH locus.

  4. To identify the sequences that regulate lambda5 and VpreB1 (show IGLL1 Proteins) expression during B cell development, the DNaseI (show DNASE1 Proteins) hypersensitive sites in the lambda5-VpreB1 (show IGLL1 Proteins) functional domain were mapped.

  5. Multiple receptor-dependent mechanisms operating at all stages of B cell development limit the contribution of B cells with Dmu (show SCN8A Proteins) heavy chain alleles to the repertoire.

Pre-B Lymphocyte 1 (VPREB1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation.

Gene names and symbols associated with Pre-B Lymphocyte 1 Proteins (VPREB1)

  • pre-B lymphocyte 1 (VPREB1)
  • immunoglobulin omega chain-like (VPREB1)
  • pre-B lymphocyte 1 (Vpreb1)
  • pre-B lymphocyte gene 1 (Vpreb1)
  • CD179a protein
  • IGI protein
  • IGVPB protein
  • VpreB protein
  • Vpreb-1 protein

Protein level used designations for Pre-B Lymphocyte 1 Proteins (VPREB1)

pre-B lymphocyte 1 , pre-B lymphocyte gene 1 , CD179 antigen-like family member A , CD179a , immunoglobulin iota chain , v(pre)B protein , Immunoglobulin lambda Vpreb1 chain

GENE ID SPECIES
458686 Pan troglodytes
698810 Macaca mulatta
486411 Canis lupus familiaris
7441 Homo sapiens
407114 Bos taurus
100328957 Oryctolagus cuniculus
303782 Rattus norvegicus
22362 Mus musculus
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