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PMEL encodes a melanocyte-specific type I transmembrane glycoprotein. Additionally we are shipping PMEL Kits (14) and PMEL Proteins (11) and many more products for this protein.
Showing 10 out of 238 products:
Human Polyclonal PMEL Primary Antibody for WB - ABIN657675
Leonhardt, Vigneron, Rahner, Van den Eynde, Cresswell: Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction. in The Journal of biological chemistry 2010
Show all 5 references for ABIN657675
Cow (Bovine) Polyclonal PMEL Primary Antibody for IHC, WB - ABIN2782746
Theos, Truschel, Tenza, Hurbain, Harper, Berson, Thomas, Raposo, Marks: A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. in Developmental cell 2006
our work attempts to provide structural insights into the RPT domain structure and to elucidate its contribution to Pmel17 amyloid fibril formation.
These findings help to clarify the mechanism of T-cell recognition of gp100 during melanoma responses and could direct the development of altered peptides for vaccination.
Data suggest that the Kringle-like domain of PMEL facilitates post-endoplasmic reticulum processing of disulfide-bonded PMEL dimers and promotes formation of PMEL functional amyloid fibrillar structures within multivesicular endosomes.
mutant N-terminally extended peptides exhibited significantly increased HLA-A*02:01 binding affinity and elicited CD8 (show CD8A Antibodies)(+) T cell stimulation in vitro similar to the wtgp100209-217 epitope.
Data indicate that repeat domain (RPT) derived from Pmel17 aggregation kinetics were influenced only by lysolipid-containing phospholipid vesicles.
Melanosome-autonomous regulation of size and number: the OA1 (show GPR143 Antibodies) receptor sustains PMEL expression.
SIL-TAL1 (show TAL1 Antibodies) rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.
the molecular basis for the distinct trafficking and morphogenetic properties of PMEL and GPNMB is the PKD (show PRKD1 Antibodies) domain
Data indicat that the N-terminal region of PMEL/Pmel17 is essential for the formation of melanosomal fibrils.
BACE2 cle (show BACE Antibodies)aves the integra (show BACE2 Antibodies)l membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis.
Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R (show MSHR Antibodies) and PMEL genes.
no convincing recombination events were found between the SILV c.64A>G mutation and the Dc locus
the complex expression pattern of the bovine SILV gene in pigmented and non-pigmented tissues
Prophylactic and therapeutic vaccinations of mice with MCMV-gp100KGP effectively protected mice from highly aggressive lung B16-F10 (show F10 Antibodies) melanoma, and the protection was mediated by gp100-specific CD8 (show CD8A Antibodies)(+) T cells
the BACE1 (show BACE Antibodies) homologue BACE2 (show BACE2 Antibodies) processes PMEL to generate functional amyloids
A long-peptide vaccine formulation of 20-mer (show ERH Antibodies) synthetic peptide elicits gp100-specific CD8 (show CD8A Antibodies) T cells from the endogenous repertoire.
Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation.
Pmel17 gene expression is Microphthalmia-associated transcription factor (show MITF Antibodies)-dependent in the mouse embryo.
These data reveal a dual sorting defect in a natural mutant of Pmel17 and support a requirement of endocytic trafficking in Pmel17 fibril formation.
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
melanocyte protein PMEL
, melanocyte protein Pmel 17
, melanocyte protein mel 17
, melanocytes lineage-specific antigen GP100
, melanoma-associated ME20 antigen
, melanosomal matrix protein17
, silver locus protein homolog
, silver, mouse, homolog of
, silver homolog
, retinal pigment epithelial-specific protein
, melanocyte protein pmel 17
, silver locus protein
, 115 kDa melanosomal matrix protein
, PMEL17 protein