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anti-Premelanosome Protein (PMEL) Antibodies

PMEL encodes a melanocyte-specific type I transmembrane glycoprotein. Additionally we are shipping PMEL Kits (14) and PMEL Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PMEL 6490 P40967
PMEL 20431  
PMEL 362818  
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Top anti-PMEL Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB SILV Antibody (Center) (ABIN657675) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the SILV antibody detected the SILV protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated FACS, IF HEK293T cells transfected with either pCMV6-ENTRY SILV (RC200663)(Red) or empty vector control plasmid(Blue) were immunostained with anti-SILV mouse monoclonal(ABIN2452228, Dilution 1:1,000), and then analyzed by flow cytometry Anti-SILV mouse monoclonal antibody (ABIN2452228) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SILV (RC200663). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IHC HEK293T cells transfected with either pCMV6-ENTRY SILV (RC200663) (Red) or empty vector control plasmid (Blue) were immunostained with anti-SILV mouse monoclonal (ABIN2452229, Dilution 1:1,000), and then analyzed by flow cytometry. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IHC, WB Anti-SILV mouse monoclonal antibody (ABIN2452277) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SILV (RC200663). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SILV (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SILV. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-SILV mouse monoclonal antibody. (ABIN2452648, Dilution 1:50) Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-SILV mouse monoclonal antibody. (ABIN2452648, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Rabbit Un-conjugated IHC (p) Human Prostate (formalin-fixed, paraffin-embedded) stained with SILV antibody ABIN790333 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 100 μL Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated IHC, WB Anti-SILV mouse monoclonal antibody (ABIN2452257) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SILV (RC200663). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SILV (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SILV. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated IF, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated FACS 100 μL Log in to see 8 to 10 Days
$493.17
Details

PMEL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-PMEL Antibodies

  1. Human Polyclonal PMEL Primary Antibody for WB - ABIN657675 : Leonhardt, Vigneron, Rahner, Van den Eynde, Cresswell: Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN657675

  2. Cow (Bovine) Polyclonal PMEL Primary Antibody for IHC, WB - ABIN2782746 : Theos, Truschel, Tenza, Hurbain, Harper, Berson, Thomas, Raposo, Marks: A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. in Developmental cell 2006 (PubMed)

More Antibodies against PMEL Interaction Partners

Human Premelanosome Protein (PMEL) interaction partners

  1. Data suggest that the Kringle-like domain of PMEL facilitates post-endoplasmic reticulum processing of disulfide-bonded PMEL dimers and promotes formation of PMEL functional amyloid fibrillar structures within multivesicular endosomes.

  2. mutant N-terminally extended peptides exhibited significantly increased HLA-A*02:01 binding affinity and elicited CD8 (show CD8A Antibodies)(+) T cell stimulation in vitro similar to the wtgp100209-217 epitope.

  3. Data indicate that repeat domain (RPT) derived from Pmel17 aggregation kinetics were influenced only by lysolipid-containing phospholipid vesicles.

  4. Melanosome-autonomous regulation of size and number: the OA1 (show GPR143 Antibodies) receptor sustains PMEL expression.

  5. SIL-TAL1 (show TAL1 Antibodies) rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.

  6. the molecular basis for the distinct trafficking and morphogenetic properties of PMEL and GPNMB is the PKD (show PRKD1 Antibodies) domain

  7. Data indicat that the N-terminal region of PMEL/Pmel17 is essential for the formation of melanosomal fibrils.

  8. BACE2 cle (show BACE Antibodies)aves the integra (show BACE2 Antibodies)l membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis.

  9. The recombinant Pmel 17 plasmids were right as we expected by DNA sequencing

  10. The most significant single-nucleotide polymorphism in the 12q13.2 locus is located immediately upstream of the promoter region of PMEL for vitiligo in Han Chinese.

Cow (Bovine) Premelanosome Protein (PMEL) interaction partners

  1. Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R (show MSHR Antibodies) and PMEL genes.

  2. no convincing recombination events were found between the SILV c.64A>G mutation and the Dc locus

  3. the complex expression pattern of the bovine SILV gene in pigmented and non-pigmented tissues

Mouse (Murine) Premelanosome Protein (PMEL) interaction partners

  1. Prophylactic and therapeutic vaccinations of mice with MCMV-gp100KGP effectively protected mice from highly aggressive lung B16-F10 (show F10 Antibodies) melanoma, and the protection was mediated by gp100-specific CD8 (show CD8A Antibodies)(+) T cells

  2. Melanosome-autonomous regulation of size and number: the OA1 (show GPR143 Antibodies) receptor sustains PMEL expression.

  3. the BACE1 (show BACE Antibodies) homologue BACE2 (show BACE2 Antibodies) processes PMEL to generate functional amyloids

  4. A long-peptide vaccine formulation of 20-mer (show ERH Antibodies) synthetic peptide elicits gp100-specific CD8 (show CD8A Antibodies) T cells from the endogenous repertoire.

  5. Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation.

  6. Pmel17 gene expression is Microphthalmia-associated transcription factor (show MITF Antibodies)-dependent in the mouse embryo.

  7. These data reveal a dual sorting defect in a natural mutant of Pmel17 and support a requirement of endocytic trafficking in Pmel17 fibril formation.

PMEL Antigen Profile

Protein Summary

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with PMEL

  • premelanosome protein (PMEL) antibody
  • premelanosome protein (Pmel) antibody
  • D10H12S53E antibody
  • D12S53E antibody
  • D12S53Eh antibody
  • gp87 antibody
  • gp100 antibody
  • ME20 antibody
  • ME20-M antibody
  • ME20M antibody
  • MMP115 antibody
  • P1 antibody
  • P100 antibody
  • Pmel17 antibody
  • RPE1 antibody
  • Si antibody
  • SIL antibody
  • Silv antibody

Protein level used designations for PMEL

melanocyte protein PMEL , melanocyte protein Pmel 17 , melanocyte protein mel 17 , melanocytes lineage-specific antigen GP100 , melanoma-associated ME20 antigen , melanosomal matrix protein17 , silver locus protein homolog , silver, mouse, homolog of , silver homolog , retinal pigment epithelial-specific protein , melanocyte protein pmel 17 , silver locus protein , 115 kDa melanosomal matrix protein , PMEL17 protein

GENE ID SPECIES
6490 Homo sapiens
481102 Canis lupus familiaris
594851 Sus scrofa
281487 Bos taurus
20431 Mus musculus
362818 Rattus norvegicus
396007 Gallus gallus
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