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May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Antibodies (615) and PD-1 Kits (13) and many more products for this protein.
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Human PD-1 Protein expressed in Wheat germ - ABIN1314407
Matsumoto, Miyake, Matsushita, Ohnishi, Ikeda, Shiraha, Takaki, Nouso, Yamamoto: Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis. in Journal of gastroenterology and hepatology 2013
Show all 2 references for ABIN1314407
Mouse (Murine) PD-1 Protein expressed in Human Cells - ABIN2007359
Prodeus, Abdul-Wahid, Fischer, Huang, Cydzik, Gariépy: Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. in Molecular therapy. Nucleic acids 2015
Study demonstrates that PD-1(+) TIMC and intratumoral PD-L1 (show CD274 Proteins)(+) expression did not significantly impact tumor aggressiveness or clinical outcome in non-ccRCC specimens.
Immune surveillance is an important mechanism in prevention of cancer development and inhibition of growth of tumors and metastasis. Checkpoint pathways prevent immune response through multiple methods including CTLA-4 (show CTLA4 Proteins) and PD-1/PD-L1 (show CD274 Proteins) pathways.A variety of immune checkpoint inhibitors (PD-1/PD-L1 (show CD274 Proteins) and CTLA-4 (show CTLA4 Proteins) inhibitors) have been studied in recurrent and metastatic head and neck cancers with encouraging efficacy
n combination with anti-PD-1/PD-L1 (show CD274 Proteins), the CTLA-4 (show CTLA4 Proteins)-expanded T cells are prevented from being functionally inhibited when they enter into the tumor microenvironment.
The CTLA-4 (show CTLA4 Proteins) receptor was one of the first checkpoint inhibitors to be targeted with limited exploration and efficacy in sarcoma.The PD-1/PD-L1 (show CD274 Proteins) immunologic checkpoint pathway has demonstrated efficacy in many malignancies; studies are ongoing in sarcoma.
PD-1 expression is associated with a poor prognosis in gastric cancer after curative resection.
Data suggest that PD-1/PDCD1 (programmed cell death protein 1) and Tim-3/HAVCR2 (hepatitis A virus cellular receptor 2 (show HAVCR2 Proteins)) operate within the functional immune-modulatory network to promote Th2-(type-2 helper T cell-)mediated immunity at the maternal-fetal interface.
High PD-1 expression is Correlated with Non-Small Cell Lung Cancer.
findings support the use of Tim-3 (show HAVCR2 Proteins)-Tim-3L blockade together with PD-1-PD-L1 (show CD274 Proteins) blockade to reverse tumor-induced T-cell exhaustion/dysfunction in patients with colorectal cancer.
Report increased expression of PD-1 in individuals that had recently been treated for tuberculosis, and a small increase in PD-1-expression in active TB disease.
PD-1 and CTLA-4 (show CTLA4 Proteins) expression during the symptomatic phase was significantly higher in the T-cells of Acute Hepatitis A patients than in those of Acute Toxic Hepatitis patients or healthy controls.
Tim-3 (show HAVCR2 Proteins)(+) PD-1(+) CD8 (show CD8A Proteins)(+) T cells showed more evident properties associated with exhaustion than Tim-3 (show HAVCR2 Proteins)(-) PD-1(+) CD8 (show CD8A Proteins)(+) T cells.
that porcine islet-specific tolerance is dependent on PD-1, which could not be extended to skin grafts
Programmed cell death-1 engagement followed by zymosan stimulation might primarily attenuate the phosphorylation of tyrosine residue in Programmed cell death-1 receptor/ligand.
Study suggests that expression of the inhibitory receptors PD-1 and LAG-3 (show LAG3 Proteins) on CD4 (show CD4 Proteins)(+) T cells and their reduced IL-2 (show IL2 Proteins) production are common characteristic features of Plasmodium infection.
these data suggest a scenario in which microglia are involved in the regulation of experimental autoimmune encephalomyelitis by suppressing Th1 (show HAND1 Proteins)-cell differentiation via the PD-L1 (show CD274 Proteins)-nitric oxide pathway.
Blockade of TGFbeta (show TGFB1 Proteins) downregulated PD-1 and PD-L1 (show CD274 Proteins) expression and precipitated graft rejection.
PD-1 regulates peripheral T-cell responses in both human and murine rheumatoid arthritis
LAG3 (show LAG3 Proteins) and PD1 co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A Proteins)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Decidual NK, NKT (show CTSL1 Proteins) and gamma/delta T cells showed increased PD-1 expression and reduced cytotoxic potential when compared to the periphery.
The endogenous PD-1/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
May have a role in the regulation of spermatogenesis.
programmed cell death 1
, programmed cell death protein 1
, protein PD-1
, programmed death 1
, spermatogenesis associated PD1
, spermatogenesis-associated protein 2
, spermatogenesis-associated protein PD1