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May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Antibodies (579) and PD-1 Kits (13) and many more products for this protein.
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Human PD-1 Protein expressed in Wheat germ - ABIN1314407
Matsumoto, Miyake, Matsushita, Ohnishi, Ikeda, Shiraha, Takaki, Nouso, Yamamoto: Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis. in Journal of gastroenterology and hepatology 2013
Show all 2 references for ABIN1314407
Mouse (Murine) PD-1 Protein expressed in Human Cells - ABIN2007359
Prodeus, Abdul-Wahid, Fischer, Huang, Cydzik, Gariépy: Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. in Molecular therapy. Nucleic acids 2015
The quantative assessment of CD4 (show CD4 Proteins)+PD-1+ T cells in peripheral blood using flow cytometry can facilitate prognostication of patients with newly diagnosed chronic lymphocytic leukemia.
Based on the PD-L1 (show CD274 Proteins) receptor PD-1 expression on tumor-infiltrating cytotoxic cells, our data supported that expression of PD-L1 (show CD274 Proteins) on TAM (show CCNA1 Proteins) promoted apoptosis of T cells via interaction with PD-1 on CD8 (show CD8A Proteins)(+)T cells.
The incidence of PD-1 inhibitor-related pneumonitis was higher in non-small cell lung cancer and renal cell carcinoma (show MOK Proteins) during combination therapy. These findings contribute to enhance awareness among clinicians and support further investigations to meet the clinical needs
Our findings support an association between the PD-1 rs2227982 polymorphism and decreased breast cancer risk, especially in Her-2 (show ERBB2 Proteins) positive breast cancer patients in the Chinese population.
High PD-1 expression is associated with Hodgkin's lymphoma.
Our study revealed that RANK-L is a promising marker to forecast pts (show PTS Proteins)' prognosis in AML (show RUNX1 Proteins). Immune checkpoint receptor PD-1/L as well as RANK and HLA-ABC (show ABCB6 Proteins) did not show an impact on pts (show PTS Proteins)' survival.
The PD-1/PD-L1 (show CD274 Proteins) checkpoint blockade, which targets regulatory pathways in T cells to overcome immune resistance, is correlated to PD-L1 (show CD274 Proteins) expression pattern and the presence of tumor-infiltrating lymphocytes (TILs). Meanwhile, immunogenic mutation loads show significant response to checkpoint blockade, which is probably due to PD-1/L1 status and TIL (show TLR1 Proteins) content
The expression rate of PDCD1 in extranodal NK/T-cell lymphoma patients was very low.
Study demonstrates that PD-1(+) TIMC and intratumoral PD-L1 (show CD274 Proteins)(+) expression did not significantly impact tumor aggressiveness or clinical outcome in non-ccRCC specimens.
Immune surveillance is an important mechanism in prevention of cancer development and inhibition of growth of tumors and metastasis. Checkpoint pathways prevent immune response through multiple methods including CTLA-4 (show CTLA4 Proteins) and PD-1/PD-L1 (show CD274 Proteins) pathways.A variety of immune checkpoint inhibitors (PD-1/PD-L1 (show CD274 Proteins) and CTLA-4 (show CTLA4 Proteins) inhibitors) have been studied in recurrent and metastatic head and neck cancers with encouraging efficacy
PD-1 dampens antigen-specific Th17 response, thus inhibiting autoimmune arthritis
Tim-3 (show HAVCR2 Proteins)(+) PD-1(+) CD8 (show CD8A Proteins)(+) T cells showed more evident properties associated with exhaustion than Tim-3 (show HAVCR2 Proteins)(-) PD-1(+) CD8 (show CD8A Proteins)(+) T cells.
that porcine islet-specific tolerance is dependent on PD-1, which could not be extended to skin grafts
Programmed cell death-1 engagement followed by zymosan stimulation might primarily attenuate the phosphorylation of tyrosine residue in Programmed cell death-1 receptor/ligand.
Study suggests that expression of the inhibitory receptors PD-1 and LAG-3 (show LAG3 Proteins) on CD4 (show CD4 Proteins)(+) T cells and their reduced IL-2 (show IL2 Proteins) production are common characteristic features of Plasmodium infection.
these data suggest a scenario in which microglia are involved in the regulation of experimental autoimmune encephalomyelitis by suppressing Th1 (show HAND1 Proteins)-cell differentiation via the PD-L1 (show CD274 Proteins)-nitric oxide pathway.
Blockade of TGFbeta (show TGFB1 Proteins) downregulated PD-1 and PD-L1 (show CD274 Proteins) expression and precipitated graft rejection.
PD-1 regulates peripheral T-cell responses in both human and murine rheumatoid arthritis
LAG3 (show LAG3 Proteins) and PD1 co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A Proteins)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Decidual NK, NKT (show CTSL1 Proteins) and gamma/delta T cells showed increased PD-1 expression and reduced cytotoxic potential when compared to the periphery.
May have a role in the regulation of spermatogenesis.
programmed cell death 1
, programmed cell death protein 1
, protein PD-1
, programmed death 1
, spermatogenesis associated PD1
, spermatogenesis-associated protein 2
, spermatogenesis-associated protein PD1