anti-Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Antibodies

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Kits (18) and PDCD4 Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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Top anti-PDCD4 Antibodies at antibodies-online.com

Showing 10 out of 252 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, K562 cells and COS-7 cells, using PDCD4 (Phospho-Ser67) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with serum 20% 15', using PDCD4 (Phospho-Ser457) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using PDCD4 (Phospho-Ser457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB Affinity purified anti-Pdcd4 was used at a 1:100 dilution to detect Pdcd4 by immunohistochemistry on mouse colon tissue. Tissue was fixed in 4% paraformaldehyde and paraffin embedded. Tissue sections were deparaffinized and treated by trypsinization before staining. 25 μL Log in to see 1 to 2 Days
$135.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from 293 cells, using PDCD4 (Ab-457) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using PDCD4 (Ab-457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Biotin IHC, ELISA, WB Western Blot of Mouse anti-Pdcd4 phospho S457 Biotin Conjugated antibody. Lane 1: Pdcd4 recombinant protein. Lane 2: none. Load: 100 ng per lane. Primary antibody: Pdcd4 phospho S457 Biotin Conjugated antibody at 1:1,000 for overnight at 4°C. Secondary antibody: HRP Streptavidin secondary antibody at 1:40,000 for 30 min at RT. Block: MB-070 for 30 min at RT. Predicted/Observed size: 50 kDa, 50 kDa for Pdcd4 phospho S457. Other band(s): Pdcd4 phospho S457 splice variants and isoforms 50 μg Log in to see 1 to 2 Days
$295.00
Details
Human Rabbit Un-conjugated IHC (p), WB PDCD4 Antibody (Center) (ABIN657922) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the PDCD4 antibody detected the PDCD4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of PDCD4 (pS457) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of PDCD4 (pS457) expression in HeLa (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Western Blot: PDCD4 Antibody [NBP1-76738] - A-20 cell lysate with PDCD4 antibody at (A) 0.5 and (B) 1ug/ml. Immunohistochemistry-Paraffin: PDCD4 Antibody [NBP1-76738] - Mouse brain tissue with PDCD4 antibody at 2.5 ug/ml. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details

PDCD4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PDCD4 Antibodies

  1. Human Polyclonal PDCD4 Primary Antibody for IHC, IHC (p) - ABIN4344378 : Baffa, Fassan, Volinia, OHara, Liu, Palazzo, Gardiman, Rugge, Gomella, Croce, Rosenberg: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. in The Journal of pathology 2009 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1002982 : Yang, Jansen, Komar, Zheng, Merrick, Costes, Lockett, Sonenberg, Colburn: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. in Molecular and cellular biology 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal PDCD4 Primary Antibody for IP, IHC - ABIN129709 : Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230 : Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043728 : Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043755 : Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal PDCD4 Primary Antibody for IF (p), IHC (p) - ABIN731993 : Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal PDCD4 Primary Antibody for IP - ABIN188776 : Kruiswijk, Yuniati, Magliozzi, Low, Lim, Bolder, Mohammed, Proud, Heck, Pagano, Guardavaccaro: Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. in Science signaling 2012 (PubMed)

  9. Human Polyclonal PDCD4 Primary Antibody for ELISA, WB - ABIN129708 : Eto, Goto, Nakashima, Ura, Abe: Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA. in Cell death and differentiation 2011 (PubMed)

More Antibodies against PDCD4 Interaction Partners

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miRNA-96 is significantly overexpressed in glioma tissues. Moreover, miRNA-96 plays a critical role in apoptosis by inhibiting the expression of PDCD4 in glioma.

  2. Supporting the clinical relevance of our results, we found an inverse correlation between ErbB-2 (show ERBB2 Antibodies)/Stat3 (show STAT3 Antibodies) nuclear co-expression and PDCD4 expression in ErbB-2 (show ERBB2 Antibodies)-positive primary invasive breast cancer

  3. this study highlights an oncomiR role for miR (show MLXIP Antibodies)-181b in regulating PDCD4 in colorectal cancer and suggests that miR (show MLXIP Antibodies)-181b may be a novel molecular therapeutic target for colorectal cancer.

  4. Higher PDCD4 expression plays a role in polycystic ovary syndrome by affecting obesity, insulin (show INS Antibodies) resistance, lipid metabolism disorders, and granulosa cell apoptosis.

  5. results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB (show THRB Antibodies)

  6. The expression of miR (show MLXIP Antibodies)-21 and PDCD4 at messenger RNA level was evaluated by quantitative real-time polymerase chain reaction, while the protein level of PDCD4 was determined by Western blotting. Authors found that locked nucleic acid-anti-miR (show MLXIP Antibodies)-21 transfection was associated with a significant reduction in metastatic properties as assessed by the in ovo model.

  7. Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4 (show USP4 Antibodies)), which plays a role as a tumor suppressor.

  8. PDCD4 down-regulation is involved in the progression of several types of solid tumor.

  9. Results show that exosome-shuttling miR (show MLXIP Antibodies)-21 represses PDCD4 protein expression by binding to 3'-UTR (show UTS2R Antibodies) in esophageal cancer cells.

  10. miR (show MLXIP Antibodies)-21, acting on PDCD4, which interacts with Twist1 (show TWIST1 Antibodies) and represses the expression of Twist1 (show TWIST1 Antibodies), contributes to the EMT (show ITK Antibodies) induced by arsenite in transformed bronchial epithelial cells.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. -induced expression of PDCD4 is associated with increased beta cell death.

  2. miR (show MLXIP Antibodies)-155 not only directly inhibited SOCS1 (show SOCS1 Antibodies) expression, but also increased the expression of p-STAT (show STAT1 Antibodies) and PDCD4, as well as the production of proinflammation mediators IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) in atherogenesis

  3. our data suggest that Pdcd4 as a crucial regulator in SGs (show SKI Antibodies) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  4. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (show IL10 Antibodies).

  5. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) Pathway.

  6. Study found that miR-16 (show GDE1 Antibodies) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways.

  7. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  8. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  9. In conclusion, miR (show MLXIP Antibodies)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

  10. atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR (show MYLIP Antibodies)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (show NFKB1 Antibodies)/ TNF-alpha (show TNF Antibodies) pathway in cardiomyocytes.

PDCD4 Antigen Profile

Protein Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4) antibody
  • programmed cell death 4 (Pdcd4) antibody
  • programmed cell death 4b (pdcd4b) antibody
  • programmed cell death 4 (neoplastic transformation inhibitor) (pdcd4) antibody
  • programmed cell death 4 (pdcd4) antibody
  • cb45 antibody
  • D19Ucla1 antibody
  • Dug antibody
  • h731 antibody
  • Ma3 antibody
  • MGC69337 antibody
  • MGC79760 antibody
  • PDCD4 antibody
  • sb:cb45 antibody
  • Tis antibody
  • wu:fc84b08 antibody

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , programmed cell death 4 , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
448531 Xenopus (Silurana) tropicalis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
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