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The product of P4HTM belongs to the family of prolyl 4-hydroxylases. Additionally we are shipping Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) Proteins (9) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal P4HTM Primary Antibody for EM, ICC - ABIN151761
Khan, Michalopoulos, Stolz: Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. in The American journal of pathology 2006
Show all 3 references for 151761
Cow (Bovine) Polyclonal P4HTM Primary Antibody for WB - ABIN2787377
Koivunen, Tiainen, Hyvärinen, Williams, Sormunen, Klaus, Kivirikko, Myllyharju: An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha. in The Journal of biological chemistry 2007
This review will expand our knowledge of biology of HIFs, PHDs, PHD (show PDC Antibodies) inhibitors, and bone regeneration, and it may also aid the design of novel therapies for accelerating bone repair and regeneration or inhibiting bone tumours. [review]
Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia.
This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 (show HIF1A Antibodies) activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction.
Results show that P4h-tm is expressed to a high degree in the mouse retinal pigment epithelium (RPE (show RPE Antibodies)) and brain. P4h-tm-/- mice develop age-related renal dysfunction, resulting in proteinuria and impaired RPE (show RPE Antibodies) functions, which eventually lead to an AMD (show AMD1 Antibodies)-like pathology.
Adiponectin (show ADIPOQ Antibodies) increases collagen production by inducing the expression of P4H, which may play a major role in the development of the thick fibrous cap of advanced atherosclerotic plaque
chronic stabilization of Hif-1alpha (show HIF1A Antibodies) and Hif-2alpha (show EPAS1 Antibodies) by genetic knockdown of Hif-p4h-2 (show EGLN1 Antibodies) promotes cardioprotection by induction of many genes involved in glucose metabolism, cardiac function, and blood pressure.
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
hypoxia-inducible factor prolyl 4-hydroxylase
, transmembrane prolyl 4-hydroxylase
, HIF-prolyl hydroxylase 4
, P4H with transmembrane domain
, Prolyl hydroxlase domain-containing 4
, hypoxia inducible factor prolyl 4 hydroxylase
, hypoxia-inducible factor prolyl hydroxylase 4
, proline 4-hydroxylase