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Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999. Additionally we are shipping Protein Phosphatase Methylesterase 1 Proteins (15) and Protein Phosphatase Methylesterase 1 Kits (5) and many more products for this protein.
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Chicken Polyclonal PPME1 Primary Antibody for IHC, WB - ABIN2786934
Longin, Zwaenepoel, Martens, Louis, Rondelez, Goris, Janssens: Spatial control of protein phosphatase 2A (de)methylation. in Experimental cell research 2007
LCMT1 (show LCMT1 Antibodies)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Antibodies)-PP2A (show PPP2R4 Antibodies) and CaMKI (show CAMK1 Antibodies) and PME-1 networks may function in fine-tuning cell proliferation and stress response.
PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.
Data indicate that PP2A (show PPP2R4 Antibodies) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Antibodies) modulators, consisting of alpha4, PTPA (show PPP2R4 Antibodies), LCMT1 (show LCMT1 Antibodies), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
GSK-3beta (show GSK3b Antibodies) can inhibit PP2A (show PPP2R4 Antibodies) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (show LCMT1 Antibodies)
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
We propose that stabilization of this inactive, nuclear PP2A (show PPP2R4 Antibodies) pool is a major in vivo function of PME-1.
Observations identify PME-1 expression as one mechanism by which ERK (show EPHB2 Antibodies) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.
protects protein phosphatase 2A from ubiquitin/proteasome degradation
PME-1 plays a critical role in differentiation of neuroblastoma (show ARHGEF16 Antibodies) cells.
targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (show PPP2R2B Antibodies) in the nervous system and peripheral tissues
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.
protein phosphatase methylesterase 1
, phosphatase methylesterase 1
, protein phosphatase methylesterase-1
, likely mitochondrial ribosomal protein (YMS2)