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anti-Protein Phosphatase Methylesterase 1 (PPME1) Antibodies

Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999. Additionally we are shipping Protein Phosphatase Methylesterase 1 Proteins (15) and Protein Phosphatase Methylesterase 1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PPME1 51400 Q9Y570
PPME1 72590 Q8BVQ5
PPME1 361613 Q4FZT2
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Top anti-Protein Phosphatase Methylesterase 1 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PPME1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: NCI-H226 cell lysate WB Suggested Anti-PPME1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: NCI-H226 cell lysate  PPME1 is strongly supported by BioGPS gene expression data to be expressed in NCI-H226 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-PPME1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 721_B cell lysate Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-PPME1 antibody (ARP56845_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB PPME1 Antibody (C-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PPME1 antibody detected the PPME1 protein (arrow). Western blot analysis of PPME1 (arrow) using rabbit polyclonal PPME1 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PPME1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human hepatoma, using PME-1, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-PPME1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958319 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-PPME1 mouse monoclonal antibody (ABIN2453492) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPME1 (RC200009). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPME1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PPME1. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-PPME1mouse monoclonal antibody. (ABIN2453491, Dilution 1:50) Immunohistochemical staining of paraffin-embedded liver tissue using anti-PPME1mouse monoclonal antibody. (ABIN2453491, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either pCMV6-ENTRY PPME1 (RC200009) (Red) or empty vector control plasmid (Blue) were immunostained with anti-PPME1 mouse monoclonal (ABIN2453495, Dilution 1:1,000), and then analyzed by flow cytometry. Anti-PPME1 mouse monoclonal antibody (ABIN2453495) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPME1 (RC200009). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

PPME1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Protein Phosphatase Methylesterase 1 Antibodies

  1. Human Polyclonal PPME1 Primary Antibody for WB - ABIN2786933 : Longin, Zwaenepoel, Martens, Louis, Rondelez, Goris, Janssens: Spatial control of protein phosphatase 2A (de)methylation. in Experimental cell research 2007 (PubMed)

More Antibodies against Protein Phosphatase Methylesterase 1 Interaction Partners

Human Protein Phosphatase Methylesterase 1 (PPME1) interaction partners

  1. LCMT1 (show LCMT1 Antibodies)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  2. this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Antibodies)-PP2A (show PPP2R4 Antibodies) and CaMKI (show CAMK1 Antibodies) and PME-1 networks may function in fine-tuning cell proliferation and stress response.

  3. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.

  4. Data indicate that PP2A (show PPP2R4 Antibodies) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Antibodies) modulators, consisting of alpha4, PTPA (show PPP2R4 Antibodies), LCMT1 (show LCMT1 Antibodies), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  5. GSK-3beta (show GSK3b Antibodies) can inhibit PP2A (show PPP2R4 Antibodies) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (show LCMT1 Antibodies)

  6. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  7. We propose that stabilization of this inactive, nuclear PP2A (show PPP2R4 Antibodies) pool is a major in vivo function of PME-1.

  8. Observations identify PME-1 expression as one mechanism by which ERK (show EPHB2 Antibodies) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.

Mouse (Murine) Protein Phosphatase Methylesterase 1 (PPME1) interaction partners

  1. protects protein phosphatase 2A from ubiquitin/proteasome degradation

  2. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  3. PME-1 plays a critical role in differentiation of neuroblastoma (show ARHGEF16 Antibodies) cells.

  4. targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (show PPP2R2B Antibodies) in the nervous system and peripheral tissues

Protein Phosphatase Methylesterase 1 (PPME1) Antigen Profile

Protein Summary

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PPME1

  • protein phosphatase methylesterase 1 (ppme1) antibody
  • esterase/lipase/thioesterase family protein (AT4G10050) antibody
  • protein phosphatase methylesterase 1 (LOC100358403) antibody
  • protein phosphatase methylesterase 1 (PPME1) antibody
  • protein phosphatase methylesterase 1 (Ppme1) antibody
  • similar to S. cerevisiae PPE1 (YHR075C) mitochondrial ribosome small subunit protein YMS2, which resembles a phosphatase-methylesterase (PPE1) antibody
  • 1110069N17Rik antibody
  • 2700017M01Rik antibody
  • DDBDRAFT_0204584 antibody
  • DDBDRAFT_0305014 antibody
  • DDB_0204584 antibody
  • DDB_0305014 antibody
  • F28M11.4 antibody
  • fk72d03 antibody
  • PME-1 antibody
  • PME1 antibody
  • PME1MGC133824 antibody
  • RGD1309683 antibody
  • wu:fk72d03 antibody
  • zgc:56239 antibody

Protein level used designations for PPME1

protein phosphatase methylesterase 1 , phosphatase methylesterase 1 , protein phosphatase methylesterase-1 , PME-1 , likely mitochondrial ribosomal protein (YMS2)

GENE ID SPECIES
335124 Danio rerio
826596 Arabidopsis thaliana
8623168 Dictyostelium discoideum AX4
100195184 Salmo salar
100358403 Oryctolagus cuniculus
446717 Xenopus laevis
419058 Gallus gallus
51400 Homo sapiens
612812 Canis lupus familiaris
535390 Bos taurus
72590 Mus musculus
361613 Rattus norvegicus
100173996 Pongo abelii
3635974 Candida albicans SC5314
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