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Pyruvate Dehydrogenase (Lipoamide) alpha 1 Proteins (PDHA1)

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle.

list all proteins Gene Name GeneID UniProt
Human PDHA1 PDHA1 5160 P08559
Rat PDHA1 PDHA1 29554  
Mouse PDHA1 PDHA1 18597 P35486
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Yeast REACT_Mycoplasma pneumoniae His tag 1 mg Log in to see 56 to 66 Days
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More Proteins for Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaction Partners

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. oncoprotein HBXIP (show HBXIP Proteins) enhances glucose metabolism reprogramming through suppressing SCO2 (show SCO2 Proteins) and PDHA1 in breast cancer

  2. MPO (show MPO Proteins) and BPI (show BPI Proteins) in CD4 (show CD4 Proteins)(+)T-lymphocytes, and PDHA1 and MRPL42 (show MRPL42 Proteins) in CD8 (show CD8A Proteins)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

  3. Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.

  4. High HK2 (show HK2 Proteins) expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.

  5. In the presence of PPARbeta (show PPARD Proteins)/delta, Vpr induced a 3.3-fold increase in PPAR (show PPARA Proteins) response element-driven transcriptional activity, a 1.9-fold increase in PDK4 (show PDK4 Proteins) protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase (show PDP Proteins) subunit E1alpha.

  6. In this study the phenotypes of patients with PDH (show PDP Proteins) deficiency have been divided into three groups of mutations.

  7. Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 (show PDHa2 Proteins) gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.

  8. Skin fibroblast culture assay revealed PDH (show PDP Proteins) deficiency, confirmed by mutation analysis of the E1 alpha subunit (show POLG Proteins).

  9. TNFalpha (show TNF Proteins) can inhibit pulmonary artery smooth muscle cells pyruvate dehydrogenase (show PDP Proteins) activity and induce a pulmonary arterial hypertension phenotype.

  10. We provide an efficient stepwise strategy for mutation screening in pyruvate dehydrogenase (show PDP Proteins) complex genes and expand the growing list of PDHA1 mutations analyzed at the structural level

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The study provired that pyruvate dehydrogenase (show PDK2 Proteins)-deficient mutant caused the retinal drficits in zebrafish.

Mouse (Murine) Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The present findings suggest that IL-6 (show IL6 Proteins) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation

  2. Liver-specific pyruvate dehydrogenase (show PDP Proteins) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (show INS Proteins) sensitivity.

  3. PGC-1alpha regulates PDH (show PDP Proteins)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (show PDP Proteins) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.

  4. Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.

PDHA1 Protein Profile

Protein Summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PDHA1

  • pyruvate dehydrogenase (lipoamide) alpha 1 (pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1)
  • PdhA1 (pdhA1)
  • pyruvate dehydrogenase E1 component subunit alpha (pdhA1)
  • pyruvate dehydrogenase alpha subunit protein (pdhA1)
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1)
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1)
  • pyruvate dehydrogenase (PDHA1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 (Pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1b (pdha1b)
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1)
  • PDHA protein
  • Pdha-1 protein
  • Pdha1 protein
  • PDHCE1A protein
  • PHE1A protein
  • wu:fp73b04 protein
  • zgc:92705 protein

Protein level used designations for PDHA1

pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase alpha 1 , fp73b04

GENE ID SPECIES
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
418610 Gallus gallus
5160 Homo sapiens
480858 Canis lupus familiaris
100294678 Sus scrofa
407109 Bos taurus
29554 Rattus norvegicus
465525 Pan troglodytes
436672 Danio rerio
18597 Mus musculus
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