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RNF43 is a HAP95 (AKAP8L\; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]\; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008].. Additionally we are shipping RNF43 Antibodies (28) and many more products for this protein.
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Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 (show SUPT4H1 Proteins) was found to occur frequently in primary colorectal carcinoma.
RNF43 mutation constitutes an important mutated driver gene for the Serrated Neoplasia pathway in both the sporadic and familial Polyposis settings.
RNF43 is down-regulated in intrahepatic cholangiocarcinoma and may play a crucial role during development of ICC.
The finding of RNF43 mutation in sessile serrated adenoma and traditional serrated adenoma, but not in tubulovillous/villous adenoma, indicated that RNF43 mutation is an early and specific molecular aberration in the serrated colorectal carcinoma pathway.
Mutations and downregulation of RNF43 may play a critical role in the transition from adenoma to carcinoma.
PTPRK (show PTPRK Proteins)-RSPO3 (show RSPO3 Proteins) fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).
our study exhibited the expression patterns and correlation of RNF43 and p53 (show TP53 Proteins) pathway proteins involved in cell cycling
Authors also identified ring finger (show PCGF1 Proteins) 43 (RNF43), an inhibitor of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, as a target of miR (show MLXIP Proteins)-550a-5p.
RNF43 inhibits the Wnt (show WNT2 Proteins) pathway downstream of oncogenic mutations that activate the pathway.
RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis
RSPO (show RSPO1 Proteins)-LGR4 (show LGR4 Proteins)/5-ZNRF3 (show ZNRF3 Proteins)/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
RNF43 and ZNRF3 (show ZNRF3 Proteins) reduce Wnt (show WNT2 Proteins) signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt (show WNT2 Proteins) receptors for degradation
RNF43 is a HAP95 (AKAP8L\; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004
E3 ubiquitin-protein ligase RNF43
, RING finger protein 43