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anti-Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1) Antibodies

The protein encoded by RCHY1 has ubiquitin ligase activity. Additionally we are shipping Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RCHY1 68098 Q9CR50
RCHY1 25898 Q96PM5
RCHY1 289508  
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Top anti-Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RCHY1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated EIA, FACS, IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB   0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), ELISA, WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine, myenteric plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human glioma tissue labeled with Anti PIRH2 Polyclonal Antibody, Unconjugated (ABIN1386185) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, ELISA, WB 0.05 mL Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

RCHY1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Antibodies

  1. Human Monoclonal RCHY1 Primary Antibody for EIA, FACS - ABIN1108844 : Zheng, Ning, Yang: PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. in Biochemical and biophysical research communications 2007 (PubMed)
    Show all 5 references for ABIN1108844

  2. Human Monoclonal RCHY1 Primary Antibody for ELISA, WB - ABIN393831 : Yan, Zhang, Di, Shi, Rao, Huo: A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination. in FEBS letters 2010 (PubMed)
    Show all 5 references for ABIN393831

  3. Human Monoclonal RCHY1 Primary Antibody for ICC, FACS - ABIN1724723 : Duan, Gao, Druhan, Zhu, Morrison, Otterson, Villalona-Calero: Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. in Journal of the National Cancer Institute 2004 (PubMed)
    Show all 2 references for ABIN1724723

  4. Cow (Bovine) Polyclonal RCHY1 Primary Antibody for WB - ABIN2775660 : Maruyama, Miyajima, Bohgaki, Tsukiyama, Shigemura, Nonomura, Hatakeyama: Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. in Molecular and cellular biochemistry 2007 (PubMed)

More Antibodies against Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Interaction Partners

Pig (Porcine) Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1) interaction partners

  1. This study showed that ORF3 (show ASZ1 Antibodies) protein of porcine circovirus type 2 interacted competitively with p53 tumor suppressor protein (show TP53 Antibodies) in binding to porcine Pirh2.

  2. Results show that the PCV2 ORF3 (show ASZ1 Antibodies) protein specifically interacts with pPirh2 and inhibits its stabilization; this may lead to increasing p53 (show TP53 Antibodies) expression, resulting in apoptosis.

Mouse (Murine) Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1) interaction partners

  1. Findings indicate that PIRH2 has central roles in the ubiquitylation of Chk2 (show CHEK2 Antibodies) and its turnover and in the regulation of its function.

  2. This study provides evidence that the ubiquitination of p73 (show ARHGAP24 Antibodies) mediated by Pirh2 represents an important pathway for controlling the suppressive function of p73 (show ARHGAP24 Antibodies)

  3. these data reveal the in vivo roles of Pirh2 in the regulation of p53 and c-Myc stability and support its role as a tumor suppressor

  4. Data show that Pirh2 monoubiquitinates PolH (show POLH Antibodies) at one of multiple lysine residues, and that monoubiquitination of PolH (show POLH Antibodies) inhibits its ability to interact with PCNA (show PCNA Antibodies) and bypass UV-induced lesions, leading to decreased viability.

  5. cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase (show UBE2K Antibodies) activity [androgen-receptor N-terminal-interacting protein; mARNIP]

  6. Pirh2 (Zfp363), a gene regulated by p53 (show TP53 Antibodies), encodes a RING-H2 domain-containing protein with intrinsic ubiquitin-protein ligase (show UBE2K Antibodies) activity. Pirh2 physically interacts with p53 (show TP53 Antibodies) and promotes ubiquitination and degradation of p53 (show TP53 Antibodies) independently of Mdm2 (show MDM2 Antibodies).

  7. These results are consistent with the hypothesis that increased Pirh2 expression affects lung tumorigenesis by reducing p53 (show TP53 Antibodies) activity.

  8. Pirh2 acts as a negative regulator of p27(Kip1 (show CDKN1B Antibodies)) function by promoting ubiquitin-dependent proteasomal degradation

Human Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1) interaction partners

  1. The Hoxa2 (show HOXA2 Antibodies)-mediated decay of RCHY1 involves both the 19S and 20S proteasome (show PSMA5 Antibodies) complexes

  2. Tumor suppressor p63 (show RPE65 Antibodies) regulates expression of ubiquitin ligase PIRH2.

  3. Overexpression of Pirh2 decreased the replication of prototype foamy virus, whereas knockdown of Pirh2 with specific siRNA increased PFV replication.

  4. Findings indicate that PIRH2 has central roles in the ubiquitylation of Chk2 (show CHEK2 Antibodies) and its turnover and in the regulation of its function.

  5. Pirh2 has a physiologically relevant role in keratinocyte differentiation through the posttranslational modification of p63 (show RPE65 Antibodies) protein.

  6. suggested that the interaction of SCYL1BP1 (show GORAB Antibodies)/Pirh2 could accelerate Pirh2 degradation through an ubiquitin-dependent pathway. SCYL1BP1 (show GORAB Antibodies) may function as an important tumor suppressor gene in HCC (show FAM126A Antibodies) development

  7. Compared to full-length PIRH2A, PIRH2E lacks amino acids 235-261, while PIRH2F is missing C-terminal amino acids 227-261 and both isoforms harbor the RING domain.

  8. low expression of human PIRH2 in lung, ovarian, and breast cancers correlates with decreased patients' survival

  9. Data show that Pirh2 monoubiquitinates PolH (show POLH Antibodies) at one of multiple lysine residues, and that monoubiquitination of PolH (show POLH Antibodies) inhibits its ability to interact with PCNA (show PCNA Antibodies) and bypass UV-induced lesions, leading to decreased viability.

  10. Pirh2 promotes the proteasomal turnover of TAp73 (show TP73 Antibodies), and thus targeting Pirh2 to restore TAp73 (show TP73 Antibodies)-mediated growth suppression in p53 (show TP53 Antibodies)-deficient tumors may be developed as a novel anti-cancer strategy.

Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1) Antigen Profile

Protein Summary

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with RCHY1

  • Pirh2 (LOC100038006) antibody
  • ring finger and CHY zinc finger domain containing 1 (Rchy1) antibody
  • ring finger and CHY zinc finger domain containing 1 (RCHY1) antibody
  • ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase (RCHY1) antibody
  • ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase (Rchy1) antibody
  • ARNIP antibody
  • CHIMP antibody
  • PIRH2 antibody
  • PRO1996 antibody
  • RNF199 antibody
  • Zfp363 antibody
  • ZNF363 antibody

Protein level used designations for RCHY1

CH-rich-interacting match with PLAG1 , E3 ubiquitin-protein ligase Pirh2 , RING finger and CHY zinc finger domain-containing protein 1 , androgen receptor N-terminal-interacting protein , zinc finger protein 363 , CH-rich interacting match with PLAG1 , RING finger protein 199 , androgen-receptor N-terminal-interacting protein , p53-induced protein with a RING-H2 domain

GENE ID SPECIES
100038006 Sus scrofa
68098 Mus musculus
540733 Bos taurus
25898 Homo sapiens
289508 Rattus norvegicus
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