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anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Antibodies

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping RUNX1T1 Proteins (6) and RUNX1T1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
RUNX1T1 362489  
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Top anti-RUNX1T1 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RUNX1T1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Xenopus laevis Rabbit Un-conjugated WB Human 721_B; Host: Rabbit. Target Name: WT1 . Sample Tissue: 721_B . Antibody Dilution: 1.0ug/ml. RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B.; RUNX1T1 antibody - middle region in Human 721_B cells using Western Blot Human HepG2; WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/ml. Positive Control: HepG2 cell lysate. There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2.; RUNX1T1 antibody - middle region in Human HepG2 cells using Western Blot 0.1 mg Log in to see 6 to 8 Days
$335.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IF, WB Anti-RUNX1T1 mouse monoclonal antibody (ABIN2455775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1 (RC222426). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated ChIP, ELISA 50 μL Log in to see 2 to 3 Days
$283.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12. Lane 1: RUNX1T1 transfected lysate(67.566 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged RUNX1T1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

RUNX1T1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) ,


Rat (Rattus) ,


Top referenced anti-RUNX1T1 Antibodies

  1. Human Polyclonal RUNX1T1 Primary Antibody for ELISA, WB - ABIN560189 : Abdelhaleem: RNA helicases: regulators of differentiation. in Clinical biochemistry 2005 (PubMed)
    Show all 4 references for ABIN560189

  2. Chicken Polyclonal RUNX1T1 Primary Antibody for WB - ABIN2787562 : Salat, Liefke, Wiedenmann, Borggrefe, Oswald: ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes. in Molecular and cellular biology 2008 (PubMed)

  3. Xenopus laevis Polyclonal RUNX1T1 Primary Antibody for WB - ABIN1108915 : Lausen, Cho, Liu, Werner: The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against RUNX1T1 Interaction Partners

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Exon splicing patterns in the human RUNX1 (show RUNX1 Antibodies)-RUNX1T1 fusion gene present in acute myeloid leukemia (show BCL11A Antibodies) patients have been decoded.

  2. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (show RUNX1 Antibodies)-ETO/RUNX1 (show RUNX1 Antibodies)-RUNX1T1 is facilitated by interaction with the chaperonin (show HSPD1 Antibodies) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (show HSP70 Antibodies)).

  3. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

  4. A substantial fraction of AML1 (show RUNX1 Antibodies)-ETO/p300 (show EP300 Antibodies) co-localization occurs near TSSs in promoter regions associated with transcriptionally active loci.

  5. minimal residual disease determined by RUNX1 (show RUNX1 Antibodies)/RUNX1T1 transcript levels could identify allogeneic hematopoietic stem cell transplantation t(8;21) (q22;q22) acute myeloid leukemia (show BCL11A Antibodies) patients who are at high risk for relapse, together with c-KIT (show KIT Antibodies) mutations

  6. identify a high-frequency mutation in t(8;21)/RUNX1 (show RUNX1 Antibodies)-RUNX1T1 acute myekoid leukemia (AML (show RUNX1 Antibodies)) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 (show ASXL2 Antibodies) mutations in this unique subset of AML (show RUNX1 Antibodies)

  7. RUNX1 (show RUNX1 Antibodies)/ETO-induced DNA damage and apoptosis in human primary CD34 (show CD34 Antibodies)+ hematopoietic progenitors are rescued by activating c-Kit (show KIT Antibodies) mutations

  8. In t(8;21) acute myelogenous leukemia (AML (show RUNX1 Antibodies)), the acquisition of AML1 (show RUNX1 Antibodies)/ETO is not sufficient, and the subsequent upregulation of AML1 (show RUNX1 Antibodies)/ETO and the additional c-KIT (show KIT Antibodies) mutant signaling are critical steps for transformation into leukemic stem cells.

  9. Our data shows that upregulated of the RUNX1 (show RUNX1 Antibodies)-RUNX1T1 gene set maybe an important factor contributing to the etiology of ccRCC.

  10. RUNX1T1 gene may participate in t(8;21)(q22;q22)-dependent leukemic transformation due to its multiple interactions in cell regulatory network particularly through synergistic or antagonistic effects in relation to activity of RUNX1 (show RUNX1 Antibodies)-RUNX1T1 fusion gene.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Data show that RUNX1 (show RUNX1 Antibodies)-ETO;c-Kit (show KIT Antibodies)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) in a fraction (51%) of reconstituted mice.

  2. Self-renewal induced by AML1 (show RUNX1 Antibodies)/ETO in primary murine progenitors was inhibited when Aes (show AES Antibodies) was decreased or absent.

  3. AML1 (show RUNX1 Antibodies)-ETO synergizes with an ICSBP (show IRF8 Antibodies) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  4. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (show CEBPB Antibodies) and a novel regulator of early adipogenesis

  5. the loss of the molecular events of AML1 (show RUNX1 Antibodies)-ETO C-terminal NCoR (show NCOR1 Antibodies)/SMRT (show NCOR2 Antibodies)-interacting domain transforms AML1 (show RUNX1 Antibodies)-ETO into a potent leukemogenic protein

  6. p15(Ink4b (show CDKN2B Antibodies)) loss must be accompanied by additional oncogenic changes for RUNX1 (show RUNX1 Antibodies)-ETO-associated AML (show RUNX1 Antibodies) to develop

  7. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  8. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (show RUNX1 Antibodies)-ETO

RUNX1T1 Antigen Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) antibody
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1) antibody
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) antibody
  • AML1T1 antibody
  • Cbfa2t1 antibody
  • Cbfa2t1h antibody
  • CDR antibody
  • ETO antibody
  • MTG8 antibody
  • si:ch211-232j17.1 antibody
  • wu:fi14b07 antibody
  • zgc:154044 antibody
  • ZMYND2 antibody

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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