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anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) Antibodies

may act as a GTP/GDP-binding protein\; may play a role in signal transduction in the retina [RGD, Feb 2006].. Additionally we are shipping SAG Kits (34) and SAG Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SAG 20215 P20443
SAG 6295 P10523
SAG 25539 P15887
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Top anti-SAG Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Rat Mouse Un-conjugated ICC, IHC (fro), IF, WB PDS-1 staining bovine retina (the rod outer section) at 1:100 50 μL Log in to see 5 to 6 Days
$402.29
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with Etoposide 25uM 60', using Arrestin 1 (Phospho-Ser412) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Arrestin 1 (Phospho-Ser412) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from A549 cells, treated with Etoposide 25uM 60', using Arrestin 1 (Ab-412) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Arrestin 1 (Ab-412) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, WB Blot of bovine retinal extracts probed with ABIN1580413. The antibody stains a band corresponding to retinal arrestin at about 48 kDa. Confocal image of a pig retina stained with ABIN1580413 (green). Visual arrestin is most abundant in the outer segments (OS) and inner surface of the outer nuclear layer (ONL), and can be used to identify components of rod photoreceptor cells. (Cone photoreceptors have a different arrestin isotype). Other retinal layers are inner segments (IS), outer plexiform layer (OPL), inner nuclear layer (INL) and inner plexiform layer (IPL). The red stain is Fox2, an RNA binding nuclear protein related to Fox3/NeuN, which stains nuclei of horizontal neurons and some other neurons in the INL and IPL. Nuclear DNA was revealed with DAPI (blue). 100 μL Log in to see 2 to 3 Days
$220.00
Details
Human Goat Un-conjugated IP, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Plasmodium falciparum Mouse Un-conjugated ELISA, WB   1 mg Log in to see 4 to 5 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$365.20
Details
Cow Mouse Un-conjugated IHC (fro), IF, WB 100 μL Log in to see 5 to 6 Days
$506.80
Details
Cow Mouse Un-conjugated IF, IHC (p), WB   50 μg Log in to see 5 to 6 Days
$478.80
Details

SAG Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Human
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Rat (Rattus)
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Top referenced anti-SAG Antibodies

  1. Human Monoclonal SAG Primary Antibody for ICC, IF - ABIN1580413 : Dorey, Faure: [Isolation and characterization of a retinal antigen inducing experimental autoimmune uveo-retinitis]. in Annales d'immunologie 1977 (PubMed)
    Show all 4 references for ABIN1580413

  2. Rat (Rattus) Monoclonal SAG Primary Antibody for ICC, IHC (fro) - ABIN108637 : Banga, LeRoy, Suleyman, Kasp, Brown, Dumonde: Analysis of antigenic determinants of retinal S-antigen with monoclonal antibodies. in Investigative ophthalmology & visual science 1988 (PubMed)
    Show all 2 references for ABIN108637

More Antibodies against SAG Interaction Partners

Mouse (Murine) S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) interaction partners

  1. The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization.

  2. ARR4 modulates essential functions in high acuity vision and downstream cellular signaling pathways that are not fulfilled or substituted by the coexpression of ARR1, despite its high expression levels in all mouse cones.

  3. crystal structure of a constitutively active form of human rhodopsin (show RHO Antibodies) bound to a pre-activated form of the mouse visual arrestin, determined by serial femtosecond X-ray laser crystallography

  4. Sag (show RNF7 Antibodies) is essential for embryonic vasculogenesis and tumor angiogenesis.

  5. SAG (show RNF7 Antibodies) knockdown caused the accumulation of proapoptotic Bax (show BAX Antibodies) and SARM (show SARM1 Antibodies), imbalance of Bcl-2 (show BCL2 Antibodies)/Bax (show BAX Antibodies) in the mitochondria, induction of cytosolic cytochrome c (show CYCS Antibodies) and activation of caspases, all of which led to disequilibrium between life and death of macrophages.

  6. tetrameric visual arrestin 1 is a biomarker for retinal function in diabetic mice, assessed by MRI (show C7ORF49 Antibodies)

  7. The data suggest that monomeric arrestin-1 is cytotoxic and WT arrestin-1 protects rods by forming mixed oligomers with the mutant and/or competing with it for the binding to non-receptor partners.

  8. Findings suggest a role for Bardet-Biedl syndrome 5 (BBS5) in regulating light-dependent translocation of arrestin1 (Arr1).

  9. Visual arrestin interaction with clathrin adaptor AP-2 (show TFAP2A Antibodies) regulates photoreceptor survival in the vertebrate retina.

  10. the 139-loop stabilizes basal conformation of arrestin-1 and acts as a brake, preventing its binding to non-preferred forms of rhodopsin (show RHO Antibodies).

Human S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) interaction partners

  1. Macular dysfunction can occur in Oguchi disease with the 1147delA mutation in the SAG (show DMBT1 Antibodies) gene.

  2. NEDD4-1 (show NEDD4 Antibodies) overexpression sensitizes cancer cells to etoposide-induced apoptosis by reducing SAG (show DMBT1 Antibodies) levels through targeted degradation. SAG (show DMBT1 Antibodies) is added to a growing list of NEDD4-1 (show NEDD4 Antibodies) substrates and mediates its biological function.

  3. Sag (show DMBT1 Antibodies) is a Kras-cooperating oncogene (show RAB1A Antibodies) that promotes lung tumorigenesis

  4. Based on their observed affinity for arrestin-1, P-opsin (show RHO Antibodies) and inactive P-Rh very likely affect the physiological monomer-dimer-tetramer equilibrium of arrestin-1, and should therefore be taken into account when modeling photoreceptor function.

  5. Compound heterozygosity of a nonsense R193X mutation and a heterozygous deletion of 3,224 bp encompassing exon 2 in the SAG (show DMBT1 Antibodies) gene is the cause of Oguchi's disease in a Chinese family.

  6. Identification of autoantibodies specific for two retinal antigens (CRALBP (show RLBP1 Antibodies) and S-Ag) supports the concept of an autoimmunological origin of the disease.

  7. the arrestin 1147delA, which has been known as a frequent cause of Oguchi disease, also may be related to the pathogenesis of autosomal recessive RP.

  8. We describe a case of Oguchi disease with unusual findings caused by a putative heterozygous mutation in the SAG (show DMBT1 Antibodies) gene.

  9. maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association

  10. Rhodopsin (show RHO Antibodies)-arrestin complexes alter the morphology of endosomal compartments and severely damage receptor-mediated endocytic functions in retinitis pigmentosa.

Cow (Bovine) S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) interaction partners

  1. Conformational changes are involved in the arrestin-rhodopsin (show RHO Antibodies) binding interface through multiple docking modes.

  2. K2A mutations in arrestin-1, -2, and -3 significantly reduced their binding to active phosphorhodopsin.

  3. maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association

  4. We hypothesize that, although arrestin requires at least a single Rho*P to bind the membrane, a single arrestin can actually interact with a pair of receptors

  5. variant form of arrestin-1 binds rod outer segment membranes

  6. Models suggest that the phosphorylated carboxy-terminal region of rhodopsin (show RHO Antibodies), Rh(330-348), undergoes significant conformational changes and becomes structured upon binding to arrestin.

  7. arrestin and p44 bind differently to different phosphorylated rhodopsin species and that this may be due to a structural difference between p44's and arrestin's basal states.

SAG Antigen Profile

Protein Summary

may act as a GTP/GDP-binding protein\; may play a role in signal transduction in the retina

Gene names and symbols associated with SAG

  • S-antigen; retina and pineal gland (arrestin) (sag) antibody
  • S-antigen; retina and pineal gland (arrestin) b (sagb) antibody
  • S-antigen (PF10_0343) antibody
  • S-antigen; retina and pineal gland (arrestin) (SAG) antibody
  • arrestin (sag) antibody
  • S-antigen, retina and pineal gland (arrestin) (Sag) antibody
  • S-antigen; retina and pineal gland (arrestin) (Sag) antibody
  • A930001K18Rik antibody
  • ARR antibody
  • Arr1 antibody
  • arrestin antibody
  • Irbp antibody
  • MGC75721 antibody
  • MGC84416 antibody
  • RP47 antibody
  • S-AG antibody
  • sag antibody
  • sag1 antibody
  • SAGMR antibody
  • SANTI antibody
  • zgc:114197 antibody

Protein level used designations for SAG

S-antigen; retina and pineal gland (arrestin) , -antigen; retina and pineal gland (arrestin) , Arrestin Sb , S-antigen , s-arrestin-like , S-AG , S-arrestin , retinal S-antigen , rod photoreceptor arrestin , 48 kDa protein , arrestin 1 , rod arrestin , visual arrestin 1 , retinal S-antigen (48 KDa protein) , arrestin1 , arrestin, S-antigen

GENE ID SPECIES
394670 Xenopus (Silurana) tropicalis
447588 Xenopus laevis
619268 Danio rerio
810500 Plasmodium falciparum 3D7
100445407 Pongo abelii
100598651 Nomascus leucogenys
398109 Xenopus laevis
20215 Mus musculus
6295 Homo sapiens
397151 Sus scrofa
280922 Bos taurus
25539 Rattus norvegicus
403906 Canis lupus familiaris
768877 Gallus gallus
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