SAG antibody (AA 369-418)

Catalog No. ABIN1532317

The Rabbit Polyclonal anti-SAG antibody (ABIN1532317) specifically detects SAG in WB, ELISA, IHC and IF. The antibody is reactive with Human and Monkey samples.

Quick Overview for SAG antibody (AA 369-418) (ABIN1532317)

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAG antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SAG Antibody

Binding Specificity: AA 369-418

Purpose: Arrestin-β-1 Antibody

Specificity: Arrestin-β-1 Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Arrestin 1. AA range:369-418

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SAG

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Alternative Name: Arrestin 1

Background:

Synonyms: ARRB1, ARR1, Beta-arrestin-1, Arrestin beta-1

Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],

Gene Name: ARRB1

Protein Name: Beta-arrestin-1

Molecular Weight: 47 kDa

Gene ID: 408

OMIM: 107940

UniProt: P49407

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling