SAG antibody (AA 1-405)

Catalog No. ABIN6147361

Product Details anti-SAG Antibody

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Binding Specificity: AA 1-405

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MAASGKTSKS EPNHVIFKKI SRDKSVTIYL GNRDYIDHVS QVQPVDGVVL VDPDLVKGKK VYVTLTCAFR YGQEDIDVIG LTFRRDLYFS RVQVYPPVGA ASTPTKLQES LLKKLGSNTY PFLLTFPDYL PCSVMLQPAP QDSGKSCGVD FEVKAFATDS TDAEEDKIPK KSSVRLLIRK VQHAPLEMGP QPRAEAAWQF FMSDKPLHLA VSLNKEIYFH GEPIPVTVTV TNNTEKTVKK IKAFVEQVAN VVLYSSDYYV KPVAMEEAQE KVPPNSTLTK TLTLLPLLAN NRERRGIALD GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YQIKVKLTVS GFLGELTSSE VATEVPFRLM HPQPEDPAKE SYQDANLVFE EFARHNLKDA GEAEEGKRDK NDVDE

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-405 of human SAG (NP_000532.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SAG

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Alternative Name: SAG (SAG Products)

Synonyms: RP47 antibody, S-AG antibody, MGC75721 antibody, MGC84416 antibody, sag antibody, zgc:114197 antibody, SAGMR antibody, SANTI antibody, ARR antibody, sag1 antibody, A930001K18Rik antibody, Arr1 antibody, Irbp antibody, arrestin antibody, S-antigen visual arrestin antibody, S-antigen antibody, S-antigen; retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) S homeolog antibody, S-antigen; retina and pineal gland (arrestin) b antibody, S-antigen, retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) L homeolog antibody, SAG antibody, PF10_0343 antibody, sag antibody, sag.S antibody, sagb antibody, Sag antibody, sag.L antibody

Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.,SAG,RP47,S-AG,Signal Transduction,G protein signaling,SAG

Molecular Weight: 45 kDa

Gene ID: 6295

UniProt: P10523

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling