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Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Additionally we are shipping SAR1A Antibodies (48) and many more products for this protein.
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Human SAR1A Protein expressed in Escherichia coli (E. coli) - ABIN667120
Jones, Jones, Bonney, Patel, Mensenkamp, Eichenbaum-Voline, Rudling, Myrdal, Annesi, Naik, Meadows, Quattrone, Islam, Naoumova, Angelin, Infante, Levy, Roy, Freemont, Scott, Shoulders: Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. in Nature genetics 2003
Show all 2 references for ABIN667120
SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin, arresting PDIA3 (show PDIA3 Proteins) in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture.
Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin (show HBG1 Proteins) expression, predominantly through the Gialpha/JNK (show MAPK8 Proteins)/Jun (show JUN Proteins) pathway.
although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B (show SAR1B Proteins), both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo.
Sar1 mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization.
the behavior of the human of Sar1A and Sar1B (show SAR1B Proteins), a key component of the COPII family of vesicle coat proteins, was examined.
Sedlin (show TRAPPC2 Proteins) bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils.
lipid-directed and tether-assisted Sar1 organization controls membrane constriction to regulate ER export.
the intracellular trafficking of hCaR (show CXADR Proteins) from the endoplasmic reticulum is Sar1-dependent via coat protein (show GOLPH3 Proteins) complex-II vesicles.
The Sec31 (show EXOC1 Proteins) fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 (show EXOC1 Proteins) and Sec23 residues at the Sar1 GTPase (show RACGAP1 Proteins) active site explains how GTP (show AK3 Proteins) hydrolysis is triggered leading to COPII coat (show SEC23A Proteins) disassembly.
Sar 1 H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1 (show KCNJ3 Proteins)/Kir3.4 (show KCNJ5 Proteins) complex however they did not block the Gbeta1gamma2/Kir3.1 (show KCNJ3 Proteins) interaction.
Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).
GTP-binding protein Sar1A
, GTP-binding protein SAR1a
, GTP-binding protein SAR1A
, SAR1a gene homolog 1
, COPII-associated small GTPase
, SAR1 gene homolog A