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SCO1 Cytochrome C Oxidase Assembly Protein Proteins (SCO1)

Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Additionally we are shipping SCO1 Cytochrome C Oxidase Assembly Protein Antibodies (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse SCO1 SCO1 16590 P05532
SCO1 6341 O75880
Rat SCO1 SCO1 497930  
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Top SCO1 Cytochrome C Oxidase Assembly Protein Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 5 Days
$522.50
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,603.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SCO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for SCO1 Cytochrome C Oxidase Assembly Protein (SCO1) Interaction Partners

Mouse (Murine) SCO1 Cytochrome C Oxidase Assembly Protein (SCO1) interaction partners

  1. IMC-G4 cells had an additional novel c-kit gene mutation of KIT-Tyr421Cys which is considered to induce neoplastic transformation of mouse mast cells

  2. gene deficiency does not play a role in the pathogenesis of lupus in B6lpr/lpr (show FAS Proteins) mice.

  3. suggests FGF-9 has the potential to attenuate vascular cell apoptosis, activate c-Kit progenitor cells, and enhance angiogenesis and neovascularization in C57BL/6 and db/db (show LEPR Proteins) mice leading to improved cardiac function.

  4. Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L (show FLT3LG Proteins).

  5. C-kit signaling has a role in proliferation and invasion of colorectal mucinous adenocarcinoma

  6. TAK1 and IKK2 are novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

  7. Findings indicate that CD45 antigen(+) and c-Kit protein(+) hematopoietic cells were more abundant in muscle than in bone marrow between embryonic 14.5 and 17.5 days.

  8. c-kit(+) cells in the murine heart are endothelial cells and not cardiac stem cells.

  9. As SALL4A (show SALL4 Proteins) is known to impair ZBTB16 (show ZBTB16 Proteins)-mediated Kit repression [14], our study provides novel insights into the molecular mechanism by which ATRA could control KIT expression, and thereby the differentiation of Aal into A1 spermatogonia in vivo.

  10. Data show that PI3 kinase is an attractive therapeutic target in malignancies induced by proto-oncogene protein c-Kit mutations.

Human SCO1 Cytochrome C Oxidase Assembly Protein (SCO1) interaction partners

  1. Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2.

  2. Sco1 is a metallochaperone that selectively transfers Cu(I) ions based on loop recognition, whereas Sco2 is a copper-dependent thiol reductase of the cysteine ligands in the oxidase.

  3. COX20 cooperates with SCO1 and SCO2 (show SCO2 Proteins) to mature COX2 and promote the assembly of cytochrome c (show CYCS Proteins) oxidase.

  4. COX19 (show COX19 Proteins) is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A (show ATP7A Proteins)-mediated cellular copper efflux.

  5. Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues.

  6. SCO1 facilitates the transfer of copper from SCO2 (show SCO2 Proteins) to the CuA site at an early stage of COX (show COX8A Proteins) assembly in mitochondria.

  7. data suggest that both Cu(I) and Cu(II) binding are critical for normal Sco (show SNAI1 Proteins) function.

  8. Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients

  9. Sco1 has evolved to bind a metal atom via the di-Cys (show DNAJC5 Proteins) motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin (show TXN Proteins) function.

  10. These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.

SCO1 Cytochrome C Oxidase Assembly Protein (SCO1) Protein Profile

Protein Summary

Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene.

Gene names and symbols associated with SCO1

  • kit oncogene (Kit)
  • SCO cytochrome oxidase deficient homolog 1 (yeast) (SCO1)
  • SCO1 cytochrome c oxidase assembly protein (SCO1)
  • SCO1 cytochrome c oxidase assembly protein (Sco1)
  • Bs protein
  • c-KIT protein
  • CD117 protein
  • Fdc protein
  • Gsfsco1 protein
  • Gsfsco5 protein
  • Gsfsow3 protein
  • RGD1559538 protein
  • SCO1 protein
  • SCO5 protein
  • SCOD1 protein
  • SOW3 protein
  • Ssm protein
  • Tr-kit protein
  • W protein

Protein level used designations for SCO1

Dominant white spotting , SCFR , Steel Factor Receptor , belly-spot , c-kit proto-oncogene protein , dominant spotting , mast/stem cell growth factor receptor Kit , proto-oncogene c-Kit , proto-oncogene tyrosine-protein kinase Kit , spotted sterile male , tyrosine-protein kinase Kit , protein SCO1 homolog, mitochondrial , SCO cytochrome oxidase deficient homolog 1

GENE ID SPECIES
16590 Mus musculus
508586 Bos taurus
6341 Homo sapiens
497930 Rattus norvegicus
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