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SET and MYND Domain Containing 3 Proteins (SMYD3)

SMYD3 encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Additionally we are shipping SMYD3 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMYD3 64754 Q9H7B4
SMYD3 69726 Q9CWR2
Rat SMYD3 SMYD3 498295  
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Top SMYD3 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human GST tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Human His tag,DYKDDDDK Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus Human DYKDDDDK Tag Recombinant SMYD3 protein gel. SMYD3 protein was run on an SDS-PAGE gel and stained with Coomassie blue. SMYD3 activity assay. HMT assay measuring the activity of Recombinant SMYD3. Activity was detected by fluorography. 20 μg Log in to see 1 to 2 Days
$460.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SMYD3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine)

More Proteins for SET and MYND Domain Containing 3 (SMYD3) Interaction Partners

Human SET and MYND Domain Containing 3 (SMYD3) interaction partners

  1. A novel HBx-interacting protein (show HBXIP Proteins), SMYD3, was identified, leading to proposal of a novel mechanism of AP-1 (show FOSB Proteins) activation in HBV-infected cells.

  2. Postulate that AdoMet (show MAT1A Proteins) cofactor acts like a key and locks Smyd3 in a closed conformation.

  3. Results showed that SMYD3 is overexpressed in human glioma and contributes to glioma tumorigenicity through p53 (show TP53 Proteins).

  4. SMYD3 interacts with the human positive coactivator 4 (PC4 (show IFRD1 Proteins)) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion.

  5. Results support a proto-oncogenic role for SMYD3 in prostate carcinogenesis, mainly due to its methyltransferase enzymatic activity.

  6. role of histone methyltransferase SMYD3 in tumors

  7. Loss of SMYD3-HSP90 (show HSP90 Proteins) interaction leads to SMYD3 mislocalization within the nucleus, thereby losing its chromatin association. This results in reduction of SMYD3-mediated cell proliferation and, potentially, impairment of SMYD3's oncogenic activity.

  8. High SMYD3 and pSTAT3 expressions may indicate poor prognosis of patients with gastric cancer

  9. Results suggest that high expression of SMYD3 is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 (show PRDM2 Proteins) suggesting a signal transduction pathway between SMYD3 and RIZ1 (show PRDM2 Proteins).

  10. SMYD3 and MMP-9 (show MMP9 Proteins) may play important roles in tumor invasion, metastasis, and prognosis and could work as promising targets for prognostic prediction in gastric cancer.

Mouse (Murine) SET and MYND Domain Containing 3 (SMYD3) interaction partners

  1. The transcription-potentiating function of Smyd3 is restricted to a particular set of genes.

  2. Epigenetic control of Foxp3 (show FOXP3 Proteins) by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection.

  3. These findings indicate that SMYD3 plays an important role in early embryonic lineage commitment and peri (show POSTN Proteins)-implantation development through the activation of lineage-specific genes.

  4. represent the proof of principle that SMYD3 is a druggable target

  5. methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas

  6. SMYD3 depletion prevents muscle loss and fiber size decrease; findings reveal a mechanistic link between SMYD3/BRD4 (show BRD4 Proteins)-dependent transcriptional regulation, muscle mass determination, and skeletal muscle atrophy

  7. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.

SMYD3 Protein Profile

Protein Summary

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMYD3

  • SET and MYND domain containing 3 (LOC100347516)
  • SET and MYND domain containing 3 (SMYD3)
  • SET and MYND domain containing 3 (Smyd3)
  • 2410008A19Rik protein
  • bA74P14.1 protein
  • KMT3E protein
  • Zmynd1 protein
  • ZNFN3A1 protein

Protein level used designations for SMYD3

SET and MYND domain containing 3 , SET and MYND domain-containing protein 3 , bA74P14.1 (novel protein) , histone-lysine N-methyltransferase SMYD3 , zinc finger MYND domain-containing protein 1 , zinc finger protein, subfamily 3A (MYND domain containing), 1 , zinc finger, MYND domain containing 1 , SET and MYND domain-containing 3

GENE ID SPECIES
100347516 Oryctolagus cuniculus
64754 Homo sapiens
100294707 Sus scrofa
616050 Bos taurus
69726 Mus musculus
498295 Rattus norvegicus
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