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SH2B Adaptor Protein 1 Proteins (SH2B1)

SH2B1 encodes a member of the SH2-domain containing mediators family. Additionally we are shipping SH2B Adaptor Protein 1 Antibodies (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SH2B1 25970 Q9NRF2
SH2B1 20399 Q91ZM2
SH2B1 89817 Q62985
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Top SH2B Adaptor Protein 1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,213.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SH2B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for SH2B Adaptor Protein 1 (SH2B1) Interaction Partners

Human SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  2. Mutation analysis has demonstrated that variation in the SH2B1 gene is frequent in both lean and obese groups, with distinctive variations being present on either side of the weight spectrum.

  3. The rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction.

  4. 4 novel variants in SH2B1 were identified in individuals with obesity and insulin (show INS Proteins) resistance.

  5. This study highlighted the importance of two candidate genes, SH2B1 and FAIM2 (show FAIM2 Proteins), in the risk of overweight/obesity.

  6. SH2B1 can enhance neurite outgrowth and accelerate the maturation of human induced neurons under defined conditions.

  7. Data (from in excess (show RCC1 Proteins) of six genetic association studies) suggest that an SNP in SH2B1 (rs4788102) is not associated with abnormal glucose homeostasis in obese subjects of European ancestry. [META-ANALYSIS]

  8. Data show the synthetic effect of SNPs on the indices of adiposity and risk of obesity in Chinese girls, but failed to replicate the effect of five separate variants of SEC16B rs10913469, SH2B1 rs4788102, PCSK1 rs6235, KCTD15 rs29941 and BAT2 rs2844479.

  9. Common variants near BDNF (show BDNF Proteins) and SH2B1 show nominal evidence of association with snacking behavior in European populations.

  10. rare missense mutations of FTO and SH2B1 did not confer risks of obesity in Chinese Han children in our cohort

Mouse (Murine) SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  2. SH2B1 in pancreatic beta-cells promotes insulin (show INS Proteins) synthesis and secretion at least in part by enhancing activation of JAK2 (show JAK2 Proteins) and/or Pdx1 (show PDX1 Proteins) pathways in response to hormonal and nutritional signals.

  3. hepatic SH2B1 is not required for the maintenance of normal insulin (show INS Proteins) sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion.

  4. These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin (show INS Proteins)-resistant state and in response to beta-cell stress.

  5. SH2B1 is responsive to erythropoietin (show EPO Proteins) stimulation and becomes phosphorylated

  6. Leptin (show LEP Proteins)-stimulated activation of hypothalamic JAK2 (show JAK2 Proteins) and phosphorylation of hyphothalamic IRS2 (show IRS2 Proteins) were significantly impaired in SH2B1(-/-) mice.

  7. Mutations in the SH2 domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner.

  8. Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.

  9. These results suggest that SH2-Bbeta regulation of Akt partly participates in the NGF-mediated development of allergic airway challenge.

  10. These results suggest that 1) SH2-B beta specifically activates JAK2 (show JAK2 Proteins), 2) APS (show SH2B2 Proteins) negatively regulates both JAK2 (show JAK2 Proteins) and JAK1 (show JAK1 Proteins), and 3) both SH2-B beta and APS (show SH2B2 Proteins) may serve as adapter proteins for all three JAKs independent of any role they have in JAK (show JAK3 Proteins) activity.

SH2B Adaptor Protein 1 (SH2B1) Protein Profile

Protein Summary

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with SH2B Adaptor Protein 1 Proteins (SH2B1)

  • SH2B adaptor protein 1 (SH2B1)
  • SH2B adaptor protein 1 (sh2b1)
  • SH2B adaptor protein 1 (Sh2b1)
  • AI425885 protein
  • C530001K22Rik protein
  • Irip protein
  • mKIAA1299 protein
  • PSM protein
  • Sh2-b protein
  • SH2-Bb protein
  • Sh2b protein
  • SH2B3 protein
  • Sh2bpsm1 protein
  • zgc:158474 protein

Protein level used designations for SH2B Adaptor Protein 1 Proteins (SH2B1)

SH2B adapter protein 1 , SH2B adaptor protein 1 , SH2B adapter protein 1-like , SH2 domain-containing protein 1B , SH2 domain-containing putative adapter SH2-B , SH2-B signaling protein , pro-rich, PH and SH2 domain-containing signaling mediator , PSM , SH2-B PH domain containing signaling mediator 1 , SH2-B PH domain-containing signaling mediator 1 , fceRI gamma-chain-interacting protein SH2-B

GENE ID SPECIES
506066 Bos taurus
558152 Danio rerio
708160 Macaca mulatta
100064371 Equus caballus
100385268 Callithrix jacchus
100470297 Ailuropoda melanoleuca
100587926 Nomascus leucogenys
25970 Homo sapiens
20399 Mus musculus
89817 Rattus norvegicus
612792 Canis lupus familiaris
100516788 Sus scrofa
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