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anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Antibodies

SMURF1 encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. Additionally we are shipping SMURF1 Proteins (5) and SMURF1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMURF1 57154 Q9HCE7
SMURF1 75788 Q9CUN6
SMURF1 690516  
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Top anti-SMURF1 Antibodies at antibodies-online.com

Showing 10 out of 110 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB SMURF1 Antibody (Center) western blot analysis in mouse Neuro-2a cell line lysates (35µg/lane).This demonstrates the SMURF1 antibody detected the SMURF1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-SMURF1 Pab (ABIN388828) in mouse kidney tissue lysate (35 µg/lane). SMURF1(arrow) was detected using the purified polyclonal antibody. C2C12 or 2T3 cells were treated with PBS or TNF (2.5-7.5 ng/mL) for 72 h. Smurf1 and actin protein levels were detected by Western blot (ABIN388828 Smurf1 N-term antibody). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-SMURF1 Pab (ABIN388829) is used in Western blot to detect SMURF1 in HL-60 cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SMURF1 on HeLa cell (antibody concentration 10 µg/mL). SMURF1 monoclonal antibody (M01), clone 1D7 Western Blot analysis of SMURF1 expression in HeLa. 100 μg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to SMURF1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 2 ug/ml] Immunofluorescence of monoclonal antibody to SMURF1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SMURF1 expression in rat brain extract (lane 1) and MCF-7 whole cell lysates (lane 2). SMURF1 at 86KD was detected using rabbit anti- SMURF1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$240.00
Details

SMURF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SMURF1 Antibodies

  1. Human Polyclonal SMURF1 Primary Antibody for IHC (p), WB - ABIN388828 : Tajima, Goto, Yoshida, Shinomiya, Sekimoto, Yoneda, Miyazono, Imamura: Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. in The Journal of biological chemistry 2003 (PubMed)
    Show all 8 references for ABIN388828

  2. Human Polyclonal SMURF1 Primary Antibody for EIA, IHC (p) - ABIN357469 : Suzuki, Murakami, Fukuchi, Shimanuki, Shikauchi, Imamura, Miyazono: Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. in The Journal of biological chemistry 2002 (PubMed)
    Show all 6 references for ABIN357469

  3. Human Monoclonal SMURF1 Primary Antibody for IF, WB - ABIN2838593 : Franke, Balschun, Sina, Ellinghaus, Häsler, Mayr, Albrecht, Wittig, Buchert, Nikolaus, Gieger, Wichmann, Sventoraityte, Kupcinskas, Onnie, Gazouli, Anagnou, Strachan, McArdle, Mathew, Rutgeerts, Vermeire, Vatn, , Krawczak, Rosenstiel, Karlsen, Schreiber: Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). in Nature genetics 2010 (PubMed)
    Show all 5 references for ABIN2838593

  4. Human Polyclonal SMURF1 Primary Antibody for IHC (p), WB - ABIN388829 : Ebisawa, Fukuchi, Murakami, Chiba, Tanaka, Imamura, Miyazono: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN388829

  5. Human Polyclonal SMURF1 Primary Antibody for EIA, WB - ABIN954864 : Alarcón, Zaromytidou, Xi, Gao, Yu, Fujisawa, Barlas, Miller, Manova-Todorova, Macias, Sapkota, Pan, Massagué: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. in Cell 2009 (PubMed)
    Show all 4 references for ABIN954864

  6. Human Monoclonal SMURF1 Primary Antibody for IF, IHC (p) - ABIN566098 : Murakami, Mathew, Huang, Farahani, Peng, Olson, Etlinger: Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension. in Experimental biology and medicine (Maywood, N.J.) 2010 (PubMed)
    Show all 2 references for ABIN566098

  7. Human Polyclonal SMURF1 Primary Antibody for ELISA, WB - ABIN185500 : Ozdamar, Bose, Barrios-Rodiles, Wang, Zhang, Wrana: Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against SMURF1 Interaction Partners

Human SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. results reveal the regulatory circuit between RUNX2 (show RUNX2 Antibodies) and SMURF1 controls RUNX2 (show RUNX2 Antibodies) expression and regulates odntoblastic differentiation in hDPSCs.

  2. EGF (show EGF Antibodies)/Smurf1 inhibits Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (show CTNNB1 Antibodies).

  3. a model that CD166 (show ALCAM Antibodies) regulates MCAM (show MCAM Antibodies) through a signaling flow from activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and c-Raf (show RAF1 Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling to the inhibition of potential MCAM (show MCAM Antibodies) ubiquitin E3 ligases, betaTrCP (show BTRC Antibodies) and Smurf1.

  4. SND1 (show SND1 Antibodies) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (show RHOA Antibodies) ubiquitination and degradation.

  5. NF-kappaB (show NFKB1 Antibodies) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.

  6. Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.

  7. The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (show CD44 Antibodies)(high) expressing.

  8. Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1 (show WWP1 Antibodies), Smurf1 and Smurf2 (show SMURF2 Antibodies) genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.

  9. Fbxo3 (show FBXO3 Antibodies) promotes the proteasomal degradation of Smurf1. Fbxo3 (show FBXO3 Antibodies) promotes the poly-ubiquitination of Smurf1.

  10. TRIB2 (show TRIB2 Antibodies) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC Antibodies)), COP1 (show CARD16 Antibodies) and Smad ubiquitination regulatory factor 1 (Smurf1) reduced TCF4 (show TCF4 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) expression, and these effects could be enhanced by TRIB2 (show TRIB2 Antibodies).

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. Smurf1 mediates NGF (show NGFB Antibodies) signaling and ubiquitinates RhoA (show RHOA Antibodies) in growth cones, regulating the need for local translation and degradation.

  2. Smurf-mediated endocytosis of Patched1 (show PTCH1 Antibodies) is required in sonic hedgehog (show SHH Antibodies) signal reception

  3. Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.

  4. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (show AXIN1 Antibodies) negatively regulates Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.

  5. These results suggest that the JNK (show MAPK8 Antibodies)/AP-1 (show JUN Antibodies) and ERK (show EPHB2 Antibodies)/Runx2 (show RUNX2 Antibodies) signaling pathways mediate TNF-alpha (show TNF Antibodies)-dependent Smurf1 transcription.

  6. Smurf1 is a negative feedback regulator for IFN-gamma (show IFNG Antibodies) signaling by targeting STAT1 (show STAT1 Antibodies) for ubiquitination and proteasomal degradation.

  7. studies uncover a cell-cycle-independent function of Cdh1 (show CDH1 Antibodies), establishing Cdh1 (show CDH1 Antibodies) as an upstream component that governs Smurf1 activity

  8. ER stress induces Smurf1 degradation and WFS1 (show WFS1 Antibodies) up-regulation

  9. Smurf1 negatively regulates mesenchymal stem cell proliferation and differentiation by controlling JunB turnover through an ubiquitin-proteasome pathway.

  10. induction could trigger downregulation of bone morphogenetic protein signaling and cause vascular cell proliferation and remodeling in pulmonary arterial hypertension pulmonary arterial hypertension

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. Data demonstrate that Smurf1 and Smurf2 (show SMURF2 Antibodies) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

  2. In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.

SMURF1 Antigen Profile

Protein Summary

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with SMURF1

  • SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) antibody
  • SMAD specific E3 ubiquitin protein ligase 1 (LOC100220332) antibody
  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1) antibody
  • SMAD specific E3 ubiquitin protein ligase 1 (Smurf1) antibody
  • 4930431E10Rik antibody
  • mKIAA1625 antibody
  • RGD1309707 antibody

Protein level used designations for SMURF1

Smad ubiquitination regulatory factor 1 , E3 ubiquitin-protein ligase SMURF1 , SMAD specific E3 ubiquitin protein ligase 1 , e3 ubiquitin-protein ligase SMURF1-like , E3 ubiquitin ligase SMURF1 , SMAD-specific E3 ubiquitin-protein ligase 1 , Smad-specific E3 ubiquitin ligase 1 , hSMURF1 , SMAD ubiquitination regulatory factor 1 , xSMURF1

GENE ID SPECIES
416487 Gallus gallus
513902 Bos taurus
608821 Canis lupus familiaris
100063241 Equus caballus
472670 Pan troglodytes
718616 Macaca mulatta
100081555 Ornithorhynchus anatinus
100220332 Taeniopygia guttata
100456599 Pongo abelii
100465094 Ailuropoda melanoleuca
100540915 Meleagris gallopavo
100556808 Anolis carolinensis
57154 Homo sapiens
75788 Mus musculus
100621443 Sus scrofa
690516 Rattus norvegicus
398131 Xenopus laevis
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