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This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Additionally we are shipping SOX2 Proteins (31) and SOX2 Kits (10) and many more products for this protein.
Showing 10 out of 389 products:
Human Polyclonal SOX2 Primary Antibody for FACS, IF - ABIN388797
Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. in Genes & development 2003
Show all 7 references for ABIN388797
Human Polyclonal SOX2 Primary Antibody for DB - ABIN390034
Wiebe, Nowling, Rizzino: Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. in The Journal of biological chemistry 2003
Show all 5 references for ABIN390034
Human Polyclonal SOX2 Primary Antibody for EIA, FACS - ABIN4620427
Fantes, Ragge, Lynch, McGill, Collin, Howard-Peebles, Hayward, Vivian, Williamson, van Heyningen, FitzPatrick: Mutations in SOX2 cause anophthalmia. in Nature genetics 2003
Show all 5 references for ABIN4620427
Human Polyclonal SOX2 Primary Antibody for DB - ABIN650879
Gen, Yasui, Zen, Zen, Dohi, Endo, Tsuji, Wakabayashi, Itoh, Naito, Taniwaki, Nakanuma, Okanoue, Yoshikawa: SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma. in Cancer genetics and cytogenetics 2010
Show all 3 references for ABIN650879
Human Polyclonal SOX2 Primary Antibody for WB - ABIN783320
Yuan, Corbi, Basilico, Dailey: Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. in Genes & development 1995
Show all 3 references for ABIN783320
Chicken Polyclonal SOX2 Primary Antibody for IHC, WB - ABIN2777428
Wang, Liang, Yi, Zhang: Novel SOX2 mutation associated with ocular coloboma in a Chinese family. in Archives of ophthalmology 2008
Show all 2 references for ABIN2777428
Human Polyclonal SOX2 Primary Antibody for DB - ABIN650873
Laga, Lai, Zhan, Huang, Velazquez, Yang, Hsu, Murphy: Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. in The American journal of pathology 2010
Show all 2 references for ABIN650873
Chicken Polyclonal SOX2 Primary Antibody for WB - ABIN2780467
Lei, Liu, Sodja, LeBlanc, Ribecco-Lutkiewicz, Smith, Charlebois, Walker, Sikorska: S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors. in Cell death and differentiation 2005
Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 (show ATOH1 Antibodies) expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1 (show ATOH1 Antibodies).
SOX2 and ALDH1 (show ALDH1A1 Antibodies) can be considered markers of poor prognosis
DDX17 (show DDX17 Antibodies) is a Sox2-binding protein in estrogen receptor (show ESR1 Antibodies)-positive breast cancer; in reporter responsive (RR) cells but not reporter unresponsive (RU) cells, DDX17 (show DDX17 Antibodies) enhances the tumorigenic and stem-like features of Sox2 by promoting its binding to its target genes
PTCH1 (show PTCH1 Antibodies) mutations contribute to as much as 10% of ODA, identify the SHH (show SHH Antibodies) signaling pathway as a novel effector of SOX2 activity during human ocular development, and indicate that ODA is likely the result of overactive SHH (show SHH Antibodies) signaling in humans harboring mutations in either PTCH1 (show PTCH1 Antibodies) or SOX2.
A novel method using an inactivated viral particle to package and deliver four purified recombinant Yamanaka transcription factors (Sox2, Oct4 (show POU5F1 Antibodies), Klf4 (show KLF4 Antibodies), and c-Myc (show MYC Antibodies)) resulting in reprogramming of human primary fibroblasts has been described.
Data show that the expression patterns of sex determining region Y-box 2 (SOX2) and pancreatic and duodenal homeobox 1 (Pdx1 (show PDX1 Antibodies))) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).
Expression levels of OCT4, SOX2, and NANOG were evaluated by immunohistochemistry with tissue microarray slides of 436 OSCC, 362 corresponding tumor-adjacent normal (CTAN) tissues, and 71 normal uvula epithelium tissues.
Vimentin (show VIM Antibodies), Nestin (show NES Antibodies) and WT1 (show WT1 Antibodies). Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 (show PAX2 Antibodies) and NSE (show ENO2 Antibodies).
SOX2 ensures pluripotent epigenetic landscapes via interacting with histone.
Suggest that NKX6.3 (show NKX6-3 Antibodies) might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 (show CDX2 Antibodies) expression and the NKX6.3 (show NKX6-3 Antibodies) inactivation may result in intestinal metaplasia in gastric epithelial cells.
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 Antibodies) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 Antibodies) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 Antibodies) and Sox2 proteins coordinate Rax (show RAX Antibodies) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 Antibodies) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Antibodies).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
Data show that the reprogramming factors OCT4 (show POU5F1 Antibodies), SOX2, KLF4 (show KLF4 Antibodies), and MYC (show MYC Antibodies) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.
SOX2 is a regulatory factor of Prop1 (show PROP1 Antibodies) expression
our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Antibodies), Sox2, Klf4 (show KLF4 Antibodies), and Myc (show MYC Antibodies)) and cofactors and molecular mechanisms for the functional importance of Set1a (show SETD1A Antibodies) in ESCs (show NR2E3 Antibodies) and early development
These findings show that SOX2 activity is modulated by O-acetylglusosamine, and provide a novel regulatory mechanism for this crucial pluripotency transcription factor.
Besides its role in fine-tuning the precise level of Sox2, Ube2s (show UBE2S Antibodies) reinforces the self-renewing and pluripotent state of embryonic stem cells.
SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period.
Using photo-activatable Fluorescence Correlation Spectroscopy to quantify transcription factor-DNA binding in single cells of developing mouse embryos, study found that Sox2 long-lived binding varies between blastomeres and is regulated by H3R26 methylation.
Our findings clarify that mutated SOX2-positive SCs (show TWIST1 Antibodies) can underlie the pathogenesis of odontoma, through a mechanism of induction similar to embryonic odontogenesis.
The REST-miR (show MLXIP Antibodies)-21-Sox2 axis connects REST to the core nuclear pluripotency regulators in E14Tg2a.4 mESCs cultured in the absence of feeder cells.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX Antibodies) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line
Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY (sex determining region Y)-box 2
, FAD-dependent sulfhydryl oxidase-2
, sulfhydryl oxidase 1
, SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, Sox2 transcription factor
, delta EF2a
, sex-determining region Y-box 2
, transcription factor Sox-2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2