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This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Additionally we are shipping SOX2 Proteins (31) and SOX2 Kits (23) and many more products for this protein.
Showing 10 out of 379 products:
Human Polyclonal SOX2 Primary Antibody for FACS, IF - ABIN388797
Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. in Genes & development 2003
Show all 7 references for ABIN388797
Human Polyclonal SOX2 Primary Antibody for DB - ABIN390034
Wiebe, Nowling, Rizzino: Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. in The Journal of biological chemistry 2003
Show all 5 references for ABIN390034
Human Polyclonal SOX2 Primary Antibody for EIA, FACS - ABIN357437
Fantes, Ragge, Lynch, McGill, Collin, Howard-Peebles, Hayward, Vivian, Williamson, van Heyningen, FitzPatrick: Mutations in SOX2 cause anophthalmia. in Nature genetics 2003
Show all 5 references for ABIN357437
Human Polyclonal SOX2 Primary Antibody for DB - ABIN650879
Gen, Yasui, Zen, Zen, Dohi, Endo, Tsuji, Wakabayashi, Itoh, Naito, Taniwaki, Nakanuma, Okanoue, Yoshikawa: SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma. in Cancer genetics and cytogenetics 2010
Show all 3 references for ABIN650879
Human Polyclonal SOX2 Primary Antibody for WB - ABIN783320
Yuan, Corbi, Basilico, Dailey: Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. in Genes & development 1995
Show all 3 references for ABIN783320
Human Polyclonal SOX2 Primary Antibody for DB - ABIN650873
Laga, Lai, Zhan, Huang, Velazquez, Yang, Hsu, Murphy: Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. in The American journal of pathology 2010
Show all 2 references for ABIN650873
Chicken Polyclonal SOX2 Primary Antibody for IHC, WB - ABIN2777428
Wang, Liang, Yi, Zhang: Novel SOX2 mutation associated with ocular coloboma in a Chinese family. in Archives of ophthalmology 2008
Show all 2 references for ABIN2777428
Chicken Polyclonal SOX2 Primary Antibody for WB - ABIN2780467
Lei, Liu, Sodja, LeBlanc, Ribecco-Lutkiewicz, Smith, Charlebois, Walker, Sikorska: S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors. in Cell death and differentiation 2005
SOX2 ensures pluripotent epigenetic landscapes via interacting with histone.
Suggest that NKX6.3 (show NKX6-3 Antibodies) might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 (show CDX2 Antibodies) expression and the NKX6.3 (show NKX6-3 Antibodies) inactivation may result in intestinal metaplasia in gastric epithelial cells.
Both Sox2ot-7 and Sox2ot-8 are highly expressed in human cancer cell lines coinciding with SOX2, one of the pluripotency regulators.
OCT4 (show POU5F1 Antibodies) overexpression and loss of SOX2 expression are strongly associated with poor prognosis in patients with cervical cancer.
Results demonstrate that SOX2 played a central role in promoting Ewing's sarcoma cell proliferation suggesting that it may serve as a potential biomarker.
Several novel and known AKT (show AKT1 Antibodies) phosphorylation sites are identified within OCT4 (show POU5F1 Antibodies), SOX2 and KLF4 (show KLF4 Antibodies).
suggest the AKT (show AKT1 Antibodies)/SOX2 molecular axis as a regulator of breast carcinoma (BC) clonogenicity and AKT (show AKT1 Antibodies) inhibitors as promising drugs for the treatment of SOX2-positive BC
This prompts for further studies on the mechanisms behind the TP53 (show TP53 Antibodies)-induced regulation of SOX2 expression and the possible importance of hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-145 in lung cancer.
OCT4 (show POU5F1 Antibodies)-SOX2 configuration that dimerizes on a Hoxb1 (show HOXB1 Antibodies)-like composite, a canonical element with juxtaposed individual binding sites, plays a more critical role in the induction and maintenance of pluripotency.
Cancer stem cell markers are variably expressed in prostate adenocarcinoma and immunohistochemical staining for ALDH1 (show ALDH1A1 Antibodies) and EZH2 (show EZH2 Antibodies) may have a role in predicting tumour aggressiveness before treatment of prostate cancer
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 Antibodies) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 Antibodies) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 Antibodies) and Sox2 proteins coordinate Rax (show RAX Antibodies) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 Antibodies) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Antibodies).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period.
Using photo-activatable Fluorescence Correlation Spectroscopy to quantify transcription factor-DNA binding in single cells of developing mouse embryos, study found that Sox2 long-lived binding varies between blastomeres and is regulated by H3R26 methylation.
Our findings clarify that mutated SOX2-positive SCs (show TWIST1 Antibodies) can underlie the pathogenesis of odontoma, through a mechanism of induction similar to embryonic odontogenesis.
The REST-miR (show MLXIP Antibodies)-21-Sox2 axis connects REST to the core nuclear pluripotency regulators in E14Tg2a.4 mESCs cultured in the absence of feeder cells.
suggests their potential role in the maintenance of the cellular redox homeostasis in the presence of changes of SOD2 (show SOD2 Antibodies) and/or p53 (show TP53 Antibodies) protein levels
Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.
distinct interactions between Sox2 and POU-TF subclasses distinguish pluripotent ESCs (show NR2E3 Antibodies) from multipotent Neural Stem Cells (NSCs), providing molecular insight into how Oct4 (show POU5F1 Antibodies) alone can convert NSCs to pluripotency.
Data show that Sox2 transcription factor-Cre recombinase (show RAG1 Antibodies) CreER labels both supporting cells and hair cells when induced at postnatal day (P) P1.
Results suggest that Oct4 (show POU5F1 Antibodies) and Sox 2 transcription factors can decrease nucleosome occupancy in vivo at poised genes, but do not alter in vivo nucleosome occupancy at active genes.
YAP1 (show YAP1 Antibodies) regulates OCT4 (show POU5F1 Antibodies) activity and SOX2 expression to facilitate self-renewal of stem-like cell
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX Antibodies) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line
Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY (sex determining region Y)-box 2
, FAD-dependent sulfhydryl oxidase-2
, sulfhydryl oxidase 1
, SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, Sox2 transcription factor
, delta EF2a
, sex-determining region Y-box 2
, transcription factor Sox-2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2