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anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) Antibodies

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Additionally we are shipping SOX2 Proteins (31) and SOX2 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SOX2 84491 Q6IUU3
SOX2 6657 P48431
SOX2 20674 P48432
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Top anti-SOX2 Antibodies at antibodies-online.com

Showing 10 out of 389 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SOX2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HT1080 cell lysate Sample Type: 2. mouse brain extracts (80ug) 3. rat brain extract (80ug) Primary Antibody Dilution: 2ug/ml Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience Secondary Antibody Dilution: 1: 20,000 Image Submitted by: Yuzhi Chen University of Arkansas for Medical Science 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SOX2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:500Positive Control: OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts from human Umbilical cord mesenchymal stem cell using SOX2. 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-phospho-Sox2-pS249 Phospho-specific Pab(ABIN650873) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB SOX2-pS246-pS249-pS250--pS251 Antibody (ABIN651838) western blot analysis in 293,CEM cell line lysates (15 µg/lane). This demonstrates the Sox2 antibody detected the Sox2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-phospho-Sox2-pS251 Phospho-specific Pab (ABIN650879) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.1 mg Log in to see 10 to 12 Days
$375.38
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SOX2 Antibody Titration: 2.5ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35 µg/lane). SOX2(arrow) was detected using the purified polyclonal antibody. Western blot analysis of SOX2 (arrow) using rabbit polyclonal SOX2 Antibody (N-term) (ABIN388797). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SOX2 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-SOX2-S83 Antibody (ABIN390034) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details

SOX2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SOX2 Antibodies

  1. Human Polyclonal SOX2 Primary Antibody for FACS, IF - ABIN388797 : Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. in Genes & development 2003 (PubMed)
    Show all 7 references for ABIN388797

  2. Human Polyclonal SOX2 Primary Antibody for DB - ABIN390034 : Wiebe, Nowling, Rizzino: Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN390034

  3. Human Polyclonal SOX2 Primary Antibody for EIA, FACS - ABIN4620427 : Fantes, Ragge, Lynch, McGill, Collin, Howard-Peebles, Hayward, Vivian, Williamson, van Heyningen, FitzPatrick: Mutations in SOX2 cause anophthalmia. in Nature genetics 2003 (PubMed)
    Show all 5 references for ABIN4620427

  4. Human Polyclonal SOX2 Primary Antibody for DB - ABIN650879 : Gen, Yasui, Zen, Zen, Dohi, Endo, Tsuji, Wakabayashi, Itoh, Naito, Taniwaki, Nakanuma, Okanoue, Yoshikawa: SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma. in Cancer genetics and cytogenetics 2010 (PubMed)
    Show all 3 references for ABIN650879

  5. Human Polyclonal SOX2 Primary Antibody for WB - ABIN783320 : Yuan, Corbi, Basilico, Dailey: Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. in Genes & development 1995 (PubMed)
    Show all 3 references for ABIN783320

  6. Chicken Polyclonal SOX2 Primary Antibody for IHC, WB - ABIN2777428 : Wang, Liang, Yi, Zhang: Novel SOX2 mutation associated with ocular coloboma in a Chinese family. in Archives of ophthalmology 2008 (PubMed)
    Show all 2 references for ABIN2777428

  7. Human Polyclonal SOX2 Primary Antibody for DB - ABIN650873 : Laga, Lai, Zhan, Huang, Velazquez, Yang, Hsu, Murphy: Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. in The American journal of pathology 2010 (PubMed)
    Show all 2 references for ABIN650873

  8. Chicken Polyclonal SOX2 Primary Antibody for WB - ABIN2780467 : Lei, Liu, Sodja, LeBlanc, Ribecco-Lutkiewicz, Smith, Charlebois, Walker, Sikorska: S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors. in Cell death and differentiation 2005 (PubMed)

More Antibodies against SOX2 Interaction Partners

Human SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 (show ATOH1 Antibodies) expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1 (show ATOH1 Antibodies).

  2. SOX2 and ALDH1 (show ALDH1A1 Antibodies) can be considered markers of poor prognosis

  3. DDX17 (show DDX17 Antibodies) is a Sox2-binding protein in estrogen receptor (show ESR1 Antibodies)-positive breast cancer; in reporter responsive (RR) cells but not reporter unresponsive (RU) cells, DDX17 (show DDX17 Antibodies) enhances the tumorigenic and stem-like features of Sox2 by promoting its binding to its target genes

  4. PTCH1 (show PTCH1 Antibodies) mutations contribute to as much as 10% of ODA, identify the SHH (show SHH Antibodies) signaling pathway as a novel effector of SOX2 activity during human ocular development, and indicate that ODA is likely the result of overactive SHH (show SHH Antibodies) signaling in humans harboring mutations in either PTCH1 (show PTCH1 Antibodies) or SOX2.

  5. A novel method using an inactivated viral particle to package and deliver four purified recombinant Yamanaka transcription factors (Sox2, Oct4 (show POU5F1 Antibodies), Klf4 (show KLF4 Antibodies), and c-Myc (show MYC Antibodies)) resulting in reprogramming of human primary fibroblasts has been described.

  6. Data show that the expression patterns of sex determining region Y-box 2 (SOX2) and pancreatic and duodenal homeobox 1 (Pdx1 (show PDX1 Antibodies))) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).

  7. Expression levels of OCT4, SOX2, and NANOG were evaluated by immunohistochemistry with tissue microarray slides of 436 OSCC, 362 corresponding tumor-adjacent normal (CTAN) tissues, and 71 normal uvula epithelium tissues.

  8. Vimentin (show VIM Antibodies), Nestin (show NES Antibodies) and WT1 (show WT1 Antibodies). Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 (show PAX2 Antibodies) and NSE (show ENO2 Antibodies).

  9. SOX2 ensures pluripotent epigenetic landscapes via interacting with histone.

  10. Suggest that NKX6.3 (show NKX6-3 Antibodies) might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 (show CDX2 Antibodies) expression and the NKX6.3 (show NKX6-3 Antibodies) inactivation may result in intestinal metaplasia in gastric epithelial cells.

Xenopus laevis SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.

  3. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  4. Suggest that SOX2 directly upregulates FGF8 (show FGF8 Antibodies) gene expression in the early embryonic development of Xenopus.

  5. Continuous expression of Sox1 (show SOX1 Antibodies) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.

  6. direct interaction and interdependence between the Otx2 (show OTX2 Antibodies) and Sox2 proteins coordinate Rax (show RAX Antibodies) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.

  7. Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2

  8. A directional Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 has a role in pluripotency in pig embryos

  2. Overexpression of Sox2 or Oct4 (show POU5F1 Antibodies) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.

  3. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level

Cow (Bovine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Antibodies).

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Sox2 displayed relatively the same methylation levels between sperm and oocytes

Mouse (Murine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 (show ATOH1 Antibodies) expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1 (show ATOH1 Antibodies).

  2. Data show that the reprogramming factors OCT4 (show POU5F1 Antibodies), SOX2, KLF4 (show KLF4 Antibodies), and MYC (show MYC Antibodies) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  3. SOX2 is a regulatory factor of Prop1 (show PROP1 Antibodies) expression

  4. our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Antibodies), Sox2, Klf4 (show KLF4 Antibodies), and Myc (show MYC Antibodies)) and cofactors and molecular mechanisms for the functional importance of Set1a (show SETD1A Antibodies) in ESCs (show NR2E3 Antibodies) and early development

  5. These findings show that SOX2 activity is modulated by O-acetylglusosamine, and provide a novel regulatory mechanism for this crucial pluripotency transcription factor.

  6. Besides its role in fine-tuning the precise level of Sox2, Ube2s (show UBE2S Antibodies) reinforces the self-renewing and pluripotent state of embryonic stem cells.

  7. SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period.

  8. Using photo-activatable Fluorescence Correlation Spectroscopy to quantify transcription factor-DNA binding in single cells of developing mouse embryos, study found that Sox2 long-lived binding varies between blastomeres and is regulated by H3R26 methylation.

  9. Our findings clarify that mutated SOX2-positive SCs (show TWIST1 Antibodies) can underlie the pathogenesis of odontoma, through a mechanism of induction similar to embryonic odontogenesis.

  10. The REST-miR (show MLXIP Antibodies)-21-Sox2 axis connects REST to the core nuclear pluripotency regulators in E14Tg2a.4 mESCs cultured in the absence of feeder cells.

Zebrafish SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.

  2. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury

  3. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.

  4. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.

  5. Knockdown of the four B1 sox (show PIPOX Antibodies) genes sox2/3/19a/19b resulted in severe developmental abnormalities.

  6. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration

  7. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs

  8. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line

  9. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.

SOX2 Antigen Profile

Protein Summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Gene names and symbols associated with SOX2

  • SRY (sex determining region Y)-box 2 (LOC100231711) antibody
  • quiescin Q6 sulfhydryl oxidase 1 (Qsox1) antibody
  • SRY (sex determining region Y)-box 2 (SOX2) antibody
  • SRY (sex determining region Y)-box 2 (Sox2) antibody
  • SRY (sex determining region Y)-box 2 (sox2) antibody
  • SRY-box containing gene 2 (Sox2) antibody
  • SRY-box containing gene 2 (sox2) antibody
  • anop3 antibody
  • cb236 antibody
  • lcc antibody
  • mcops3 antibody
  • Qscn6 antibody
  • Qsox antibody
  • RGD1565646 antibody
  • rSOx antibody
  • sox-2 antibody
  • SRY-box2 antibody
  • wu:fb83g04 antibody
  • wu:fc14d07 antibody
  • Xsox-2 antibody
  • ysb antibody
  • zgc:65860 antibody
  • zgc:77389 antibody

Protein level used designations for SOX2

SRY (sex determining region Y)-box 2 , FAD-dependent sulfhydryl oxidase-2 , rQSOX , sulfhydryl oxidase 1 , SRY-related HMG-box gene 2 , transcription factor SOX-2 , transcription factor SOX2 , SRY-box containing gene 2 , Sox2 transcription factor , cSox2 , delta EF2a , XSox2 , XlSOX-2 , sex-determining region Y-box 2 , transcription factor Sox-2 , SRY-box 2 , SRY-related HMG-box 2 , sex determining region Y-box 2 , soxp

GENE ID SPECIES
100231711 Taeniopygia guttata
84491 Rattus norvegicus
6657 Homo sapiens
499593 Rattus norvegicus
396105 Gallus gallus
488092 Canis lupus familiaris
398000 Xenopus laevis
407739 Sus scrofa
784383 Bos taurus
101110563 Ovis aries
707039 Macaca mulatta
460869 Pan troglodytes
100379629 Felis catus
100714747 Cavia porcellus
20674 Mus musculus
378723 Danio rerio
Selected quality suppliers for anti-SOX2 (SOX2) Antibodies
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