SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (AA 89-119)

Details for Product anti-SOX2 Antibody No. ABIN388797, Supplier: Log in to see
Antigen
  • Qscn6
  • Qsox
  • Sox-2
  • rSOx
  • ANOP3
  • MCOPS3
  • RGD1565646
  • SRY-box2
  • Xsox-2
  • anop3
  • mcops3
  • sox-2
  • lcc
  • ysb
  • cb236
  • wu:fb83g04
  • wu:fc14d07
  • zgc:65860
  • zgc:77389
  • SRY (sex determining region Y)-box 2
  • quiescin Q6 sulfhydryl oxidase 1
  • SRY-box containing gene 2
  • LOC100231711
  • Qsox1
  • SOX2
  • Sox2
  • sox2
Alternatives
anti-Human SOX2 antibody for Biochemical Assay
Epitope
AA 89-119, N-Term
57
21
19
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16
15
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14
13
11
7
5
5
5
4
4
4
4
4
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3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
457
165
84
32
28
20
15
13
13
12
10
9
9
6
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4
3
2
2
1
1
1
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1
Host
Rabbit
294
171
7
Clonality (Clone)
Polyclonal ()
Conjugate
This SOX2 antibody is un-conjugated
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19
19
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11
11
9
9
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8
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6
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3
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Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
326
178
136
134
134
96
89
56
17
7
7
6
4
4
2
2
2
1
1
1
1
1
1
Options
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Immunogen This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-119 AA from the N-terminal region of human SOX2.
Clone RB14026
Isotype Ig
Specificity This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino acids from the N-terminal region of human SOX2.
Predicted Reactivity Chicken,Mouse (Murine),Xenopus laevis,Zebrafish
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SOX2 (SOX2 Antibody Abstract)
Background The intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
Synonyms: Transcription factor SOX-2
Molecular Weight 34310 Da. MW based on amino acid sequence. Theoretical pI: 9.74 Da
Gene ID 6657
UniProt P48431
Research Area Stem Cells, Transcription Factors, Signaling
Pathways Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (AA 89-119) (ABIN388797) Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35 µg/lane)...
Western Blotting (WB) image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (AA 89-119) (ABIN388797) Western blot analysis of SOX2 (arrow) using rabbit polyclonal SOX2 Antibody (N-term) ...
Immunohistochemistry (IHC) image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (AA 89-119) (ABIN388797) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOX2 an...
Product cited in: Schouten, Fratantoni, Hubens, Piersma, Pham, Bielefeld, Voskuyl, Lucassen, Jimenez, Fitzsimons: "MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells." in: Scientific reports, Vol. 5, pp. 12448, 2015 (PubMed).

Su, Qi: "Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation." in: Human molecular genetics, Vol. 22, Issue 22, pp. 4545-61, 2013 (PubMed).

Background publications Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Fantes, Ragge, Lynch, McGill, Collin, Howard-Peebles, Hayward, Vivian, Williamson, van Heyningen, FitzPatrick: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).