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Sclerostin (SOST) ELISA Kits

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (98) and Sclerostin Proteins (18) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top Sclerostin ELISA Kits at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 7.8 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests Log in to see 9 to 11 Days
$1,026.67
Details
Mouse 10pg/mL 15.6-1000 pg/mL Mouse Sclerostin/SOST PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$399.00
Details
Rat 32 pg/mL 78-5.000 pg/mL 96 Tests Log in to see 9 to 11 Days
$800.00
Details
Cow 15.63 pg/mL 4000-62.5 pg/mL   96 Tests Log in to see 11 to 13 Days
$1,026.67
Details
Guinea Pig 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Rabbit 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Monkey 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Dog 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Pig
  96 Tests Log in to see 11 to 13 Days
$707.14
Details
Sheep
  96 Tests Log in to see 11 to 13 Days
$707.14
Details

Top referenced Sclerostin ELISA Kits

  1. Human Sclerostin Primary Antibody for ELISA - ABIN457071 : Cidem, Usta, Karacan, Kucuk, Uludag, Gun: Effects of sex steroids on serum sclerostin levels during the menstrual cycle. in Gynecologic and obstetric investigation 2013 (PubMed)
    Show all 5 references for ABIN457071

  2. Rat (Rattus) Sclerostin Primary Antibody for ELISA - ABIN416496 : Kim, Lee, Jo, Song, Lim, Park, Bonewald, Kim: Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. in Life sciences 2013 (PubMed)
    Show all 2 references for ABIN416496

  3. Mouse (Murine) Sclerostin Primary Antibody for ELISA - ABIN1889353 : Brunkow, Gardner, Van Ness, Paeper, Kovacevich, Proll, Skonier, Zhao, Sabo, Fu, Alisch, Gillett, Colbert, Tacconi, Galas, Hamersma, Beighton, Mulligan: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. in American journal of human genetics 2001 (PubMed)
    Show all 2 references for ABIN1889353

More ELISA Kits for Sclerostin Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. Sclerostin is an osteocyte marker that is strongly expressed in human woven and lamellar bone and mineralizing chondrocytes

  2. similar levels in type 1 diabetes patients and controls; decrease concurrent with adolescent growth spurt (show BPIFA1 ELISA Kits)

  3. Findings indicate that sclerostin expression is closely associated with the degree of joint damage in primary knee osteoarthritis (OA), confirming its involvement in the development of OA.

  4. Results suggest that sclerostin may have a role in the development of or the response to abdominal aortic calcification in chronic kidney disease.

  5. while showing that exercise against bone loss in experimental bed rest results in greater bone formation, could not provide evidence that exercise impeded the rise in serum sclerostin and dickkopf-1 (show DKK1 ELISA Kits) levels.

  6. serum sclerostin levels were lower in nonalcoholic steatohepatitis patients than in controls.

  7. The aim of this study was to evaluate the renal handling of sclerostin.

  8. Circulating sclerostin and dickkopf-1 (show DKK1 ELISA Kits) levels in ossification of the posterior longitudinal ligament of the spine.

  9. chronic TNFalpha (tumor necrosis factor alpha (show TNF ELISA Kits))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  10. Sclerostin levels are elevated in CKD patients and are associated with inflammation, vascular lesions, uremia and (potentially) mortality.

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  2. chronic TNFalpha (tumor necrosis factor alpha (show TNF ELISA Kits))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  3. Data show that the phenotype of Notch (show NOTCH1 ELISA Kits) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (show DMP1 ELISA Kits))-Cre;Rosa(Notch (show NOTCH1 ELISA Kits)) mice hemizygous for the Dmp1 (show DMP1 ELISA Kits)-sclerostin (SOST) transgene.

  4. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (show TAZ ELISA Kits)-responsive transcriptional activity and TAZ (show TAZ ELISA Kits)-responsive gene expression, indicating a role for TAZ (show TAZ ELISA Kits) as a regulator of adipogenesis by sclerostin.

  5. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  6. Sclerostin depletion enhances tibial fracture healing.

  7. SOST gene is involved in the regulation of renal interstitial fibrosis (RIF) progression. In obstructive kidney injury, SOST gene deletion would probably enhance renal fibrogenic response and promote the progression of RIF.

  8. Data (including data from studies in knockout/transgenic mice) suggest that Lrp6 (lipoprotein receptor-related protein 6 (show LRP6 ELISA Kits)) is required for suppression of Sost expression by parathyroid hormone (show PTH ELISA Kits) (here, human PTH (show PTH ELISA Kits) peptide 1-34).

  9. These in vivo data support in vitro studies regarding the mechanism of HBM (show LRP5 ELISA Kits)-causing mutations, and imply that HBM LRP5 (show LRP5 ELISA Kits) receptors differ in their relative sensitivity to inhibition by SOST and DKK1 (show DKK1 ELISA Kits).

  10. These findings indicated that AMPK (show PRKAA1 ELISA Kits) regulated RANKL (show TNFSF11 ELISA Kits) and sclerostin expression through the mevalonate pathway in osteocytes.

Sclerostin (SOST) Antigen Profile

Antigen Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with Sclerostin (SOST) ELISA Kits

  • sclerostin (LOC100313724) antibody
  • sclerostin (SOST) antibody
  • sclerostin (Sost) antibody
  • sclerostin-like (LOC100513306) antibody
  • 5430411E23Rik antibody
  • CDD antibody
  • LOC100313724 antibody
  • VBCH antibody

Protein level used designations for Sclerostin (SOST) ELISA Kits

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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