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Sclerostin Domain Containing 1 Proteins (SOSTDC1)

SOSTDC1 is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. Additionally we are shipping SOSTDC1 Antibodies (44) and SOSTDC1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SOSTDC1 SOSTDC1 266803 Q642G2
SOSTDC1 25928 Q6X4U4
SOSTDC1 66042 Q9CQN4
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Top SOSTDC1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$763.40
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

SOSTDC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

Top referenced SOSTDC1 Proteins

  1. Human SOSTDC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098746 : Goto, Eddy: Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN1098746

  2. Human SOSTDC1 Protein expressed in Wheat germ - ABIN1320977 : Lee, Miyazawa, Shin, Kwon, Kang, Choi, Lee, Kondo, Cho, Jung: Shh signaling is essential for rugae morphogenesis in mice. in Histochemistry and cell biology 2011 (PubMed)

More Proteins for Sclerostin Domain Containing 1 (SOSTDC1) Interaction Partners

Human Sclerostin Domain Containing 1 (SOSTDC1) interaction partners

  1. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 (show CCNA2 Proteins) and cyclin E2 (show CCNE2 Proteins).

  2. Results conclude that the transcriptional repressor E4BP4 (show NFIL3 Proteins) plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 (show NFIL3 Proteins) silencing.

  3. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer

  4. Unliganded VDR (show CYP27B1 Proteins) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.

  5. DNA methylation (show HELLS Proteins) is involved in the down-regulation of SOSTDC1 expression in gastric cancer.

  6. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer.

  7. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women.

  8. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors.

  9. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways

  10. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist.

Mouse (Murine) Sclerostin Domain Containing 1 (SOSTDC1) interaction partners

  1. the in vivo inter-relationships between Bmp7 (show BMP7 Proteins) and Usag-1, was examined.

  2. Findings strongly suggest that Wise and Sost (show SOST Proteins) are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 (show LRP5 Proteins) and control the balance or levels of Wnt (show WNT2 Proteins) signaling.

  3. Interactions between BMP-7 (show BMP7 Proteins) and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations

  4. Sost (show SOST Proteins) and its paralog Sostdc1 coordinate digit number in a Gli3 (show GLI3 Proteins)-dependent manner.

  5. Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  6. Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor (show CTGF Proteins)) and gremlin (show GREM1 Proteins) in islets after high-fat diet.

  7. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7 (show BMP7 Proteins)-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 (show HOXA13 Proteins) and USAG-1.

  8. The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  9. We propose a new reaction-diffusion model in which Wnt (show WNT2 Proteins), Shh (show SHH Proteins) and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse.

  10. analyses demonstrate that the Fgf and Shh (show SHH Proteins) pathways are major downstream targets of Wise-regulated Wnt (show WNT2 Proteins) signaling.

SOSTDC1 Protein Profile

Protein Summary

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

Gene names and symbols associated with SOSTDC1

  • sclerostin domain containing 1 (SOSTDC1)
  • sclerostin domain containing 1a (sostdc1a)
  • sclerostin domain containing 1 (Sostdc1)
  • 0610006G05Rik protein
  • DKFZp469J0531 protein
  • ectodin protein
  • SOSTDC1 protein
  • Sostl protein
  • USAG-1 protein
  • USAG1 protein
  • WISE protein
  • zgc:110293 protein

Protein level used designations for SOSTDC1

sclerostin domain containing 1 , sclerostin domain-containing protein 1 , Sclerostin domain-containing protein 1 , USAG-1 , uterine sensitization-associated gene 1 protein , wnt-signaling modulator , cystine-knot containing secreted protein , ectodermal BMP inhibitor , uterine sensitization-associated protein-1 , sclerostin-like protein , uterine sensitization-associated protein 1 , context-dependent activator and inhibitor of Wnt signalling protein Wise

GENE ID SPECIES
482331 Canis lupus familiaris
550261 Danio rerio
100173799 Pongo abelii
266803 Rattus norvegicus
25928 Homo sapiens
66042 Mus musculus
378800 Gallus gallus
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