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Sialic Acid Acetylesterase Proteins (SIAE)

SIAE encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Additionally we are shipping Sialic Acid Acetylesterase Kits (12) and Sialic Acid Acetylesterase Antibodies (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIAE 22619 P70665
SIAE 363045  
SIAE 54414 Q9HAT2
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Top Sialic Acid Acetylesterase Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,651.00
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details

SIAE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , ,
, ,

Top referenced Sialic Acid Acetylesterase Proteins

  1. Human SIAE Protein expressed in Baculovirus infected Insect Cells - ABIN2005641 : Surolia, Pirnie, Chellappa, Taylor, Cariappa, Moya, Liu, Bell, Driscoll, Diederichs, Haider, Netravali, Le, Elia, Dow, Lee, Freudenberg, De Jager, Chretien, Varki, MacDonald, Gillis, Behrens, Bloch et al.: Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. ... in Nature 2010 (PubMed)

More Proteins for Sialic Acid Acetylesterase (SIAE) Interaction Partners

Mouse (Murine) Sialic Acid Acetylesterase (SIAE) interaction partners

  1. Sialate:O-acetyl esterase (show ESD Proteins) is a catalytic regulator of B cell signaling and plays an essential role in the maintenance of immunological tolerance in the B lineage.

Human Sialic Acid Acetylesterase (SIAE) interaction partners

  1. Authors determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population

  2. We found A467V SIAE variants (c.1400C>T, rs7941523) in a heterozygous state in all the patients with anti-PIT-1 (show POU1F1 Proteins) antibody syndrome.

  3. There is no evidence for SIAE genetic variants affecting patients with vitiligo (show MITF Proteins).

  4. SIAE may be associated with autoimmunity.

  5. The analysis does not support a role for rare variants in SIAE in the pathogenesis of autoimmune Addison's disease.

  6. SIAE variants play a role in primary biliary cirrhosis.

  7. These studies demonstrate that both SIAE and SOAT activities seem to be responsible for the enhanced level of Neu5,9Ac(2) in lymphoblasts, which is a hallmark in acute lymphoblastic leukemia

  8. SIAE expression is upregulated in placentas from pregnancies complicated by preeclampsia.

  9. Functionally defective germline variant of sialic acid acetylesterase (Met89Val) is not associated with type 1 diabetes mellitus and Graves' disease.

  10. odds ratio for inheriting defective SIAE alleles was 8.6 in all autoimmune subjects, 8.3 in subjects with rheumatoid arthritis, and 7.9 in subjects with type I diabetes

Sialic Acid Acetylesterase (SIAE) Protein Profile

Protein Summary

This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.

Gene names and symbols associated with SIAE

  • sialic acid acetylesterase (siae)
  • sialic acid acetylesterase (SIAE)
  • sialic acid acetylesterase (Siae)
  • AIS6 protein
  • CSE-C protein
  • CSEC protein
  • DKFZp469J191 protein
  • LSE protein
  • MGC68688 protein
  • MGC137441 protein
  • RGD1310431 protein
  • Ysg2 protein
  • zgc:56454 protein

Protein level used designations for SIAE

sialic acid acetylesterase , cytosolic sialic acid 9-O-acetylesterase homolog , sialate O-acetylesterase , sialic acid-specific 9-O-acetylesterase , sialate O-acetylesterase-like , clone 165 , yolk sac gene 2 , yolk sac protein 2 , H-Lse , sialic acid-specific acetylesterase II

GENE ID SPECIES
398827 Xenopus laevis
451636 Pan troglodytes
489311 Canis lupus familiaris
507461 Bos taurus
555385 Danio rerio
711816 Macaca mulatta
100072250 Equus caballus
100171407 Pongo abelii
100468858 Ailuropoda melanoleuca
100589083 Nomascus leucogenys
22619 Mus musculus
363045 Rattus norvegicus
54414 Homo sapiens
100521812 Sus scrofa
100343270 Oryctolagus cuniculus
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