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Sialidase 1 (Lysosomal Sialidase) Proteins (NEU1)

The protein encoded by NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Additionally we are shipping NEU1 Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEU1 18010 O35657
NEU1 24591  
NEU1 4758 Q99519
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Top NEU1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$522.50
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,008.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,008.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,014.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

NEU1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , ,
,

Top referenced NEU1 Proteins

  1. Human NEU1 Protein expressed in Escherichia coli (E. coli) - ABIN1098375 : Abdulkhalek, Amith, Franchuk, Jayanth, Guo, Finlay, Gilmour, Guzzo, Gee, Beyaert, Szewczuk: Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling. in The Journal of biological chemistry 2011 (PubMed)

More Proteins for Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaction Partners

Mouse (Murine) Sialidase 1 (Lysosomal Sialidase) (NEU1) interaction partners

  1. Neu1 (show NEURL Proteins) desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  2. Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Proteins)) interaction and endotoxemia.

  3. elastin (show ELN Proteins)-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3Kgamma (show PIK3CG Proteins) signalling pathway as a key mediator

  4. significant increases in Col1a1 (show COL1A1 Proteins), serine/threonine-protein kinase 1, Ctnnb1 (show CTNNB1 Proteins), CSRNP1 (show CSRNP1 Proteins), Ddit4 (show DDIT4 Proteins), Cyp2e1 (show CYP2E1 Proteins), and Krit1 (show KRIT1 Proteins) expressions and great decreases inreceptor D2, Neu1 (show NEURL Proteins), and Dhcr7 (show DHCR7 Proteins) expressions following long-term exposure to TiO2 NPs (show NPS Proteins)

  5. NEU1 (show NEURL Proteins) deficiency has a role in determining amyloid precursor protein (show APP Proteins) levels and amyloid-beta secretion via deregulated lysosomal exocytosis

  6. Neu1 (show NEURL Proteins) sialidase and matrix metalloproteinase-9 (show MMP9 Proteins) cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 (show TLR7 Proteins) and -9 activation, cellular signaling and pro-inflammatory responses.

  7. The activity of NEU1 (show NEURL Proteins) was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.

  8. these studies identify Neu1 (show NEURL Proteins) as a novel component of the signaling pathways of energy metabolism and glucose uptake.

  9. The rescue of sialidase activity in hypomorphic sialidase mice using helper-dependent adenovirus resulted in increased VLDL production and an increase in MTP (show LAPTM4A Proteins) levels.

  10. Data indicate that sialidases Neu1 (show NEURL Proteins) and Neu3 (show Neu3 Proteins) are present on sperm, and their activity is required for capacitation and zona pellucida binding.

Human Sialidase 1 (Lysosomal Sialidase) (NEU1) interaction partners

  1. NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment

  2. How the point mutations of the neuraminidase (show NEU Proteins) sequences affected the susceptibility of H9N2 virus to oseltamivir is still to be determined and deserve further investigations

  3. Basal Neu-1 catalytic activity is strongly increased in aged cells.

  4. Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  5. Flagellin (show FliC Proteins) drives NEU1 to desialylate MUC1 (show MUC1 Proteins), thereby increasing its adhesiveness for Pseudomonas aeruginosa and its shedding

  6. Muc1 (show MUC1 Proteins) clearly plays a significant role in enhancing the hypoxia-inducible transcription factors protective pathway during ischemic insult and recovery in kidney epithelia

  7. This study analyzed patient cells with GM1 gangliosidosis and sialidosis. A novel mutation p.R347Q is identified in NEU1 gene.

  8. The lymphocyte levels of NEU1 and ST6GAL1 (show ST6GAL1 Proteins) mRNA expression are significantly increased in erythremia.

  9. Insulin (show INS Proteins)-induced phosphorylation of the insulin receptor (show INSR Proteins) is dependent on Neu1 sialidase activity.

  10. Sialidosis should be suspected and the NEU1 gene analyzed in patients with isolated action myoclonus presenting in adulthood in the absence of other typical clinical and laboratory findings.

Cow (Bovine) Sialidase 1 (Lysosomal Sialidase) (NEU1) interaction partners

  1. NEU1 gene is not responsible for the lysosomal storage disease of Japanese Black cattle.

NEU1 Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Gene names and symbols associated with NEU1

  • sialidase 1 (lysosomal sialidase) (neu1)
  • sialidase 1 (lysosomal sialidase) (NEU1)
  • neuraminidase 1 (neu1)
  • neuraminidase 1 (Neu1)
  • AA407268 protein
  • AA407316 protein
  • Aglp protein
  • Apl protein
  • Bat-7 protein
  • Bat7 protein
  • G9 protein
  • Map-2 protein
  • MGC81958 protein
  • NANH protein
  • NEU protein
  • Neu-1 protein
  • SIAL1 protein

Protein level used designations for NEU1

sialidase 1 (lysosomal sialidase) , neuraminidase , sialidase-1 , isotocin , Isotocin-neurophysin IT 1 , neuraminidase 1 , sialidase-1-like , G9 sialidase , HLA-B-associated transcript 7 , N-acetyl-alpha-neuraminidase 1 , lysosomal sialidase , sialidase 1 , acetylneuraminyl hydrolase , exo-alpha-sialidase

GENE ID SPECIES
444511 Xenopus laevis
471968 Pan troglodytes
716740 Macaca mulatta
100136555 Salmo salar
100342130 Oryctolagus cuniculus
100408501 Callithrix jacchus
100595428 Nomascus leucogenys
18010 Mus musculus
24591 Rattus norvegicus
4758 Homo sapiens
481717 Canis lupus familiaris
100124381 Sus scrofa
505554 Bos taurus
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