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The protein encoded by NEU4 belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Additionally we are shipping Sialidase 4 Proteins (3) and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal NEU4 Primary Antibody for EIA, IHC (p) - ABIN954804
Bigi, Morosi, Pozzi, Forcella, Tettamanti, Venerando, Monti, Fusi: Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively. in Glycobiology 2010
Show all 5 references for ABIN954804
Human Polyclonal NEU4 Primary Antibody for WB - ABIN2774018
Stamatos, Liang, Nan, Landry, Cross, Wang, Pshezhetsky: Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. in The FEBS journal 2005
Human Polyclonal NEU4 Primary Antibody for IHC (p), WB - ABIN654343
Xin, Rual, Hirozane-Kishikawa, Hill, Vidal, Boone, Thierry-Mieg: Shifted Transversal Design smart-pooling for high coverage interactome mapping. in Genome research 2009
The silencing or chemical inhibition of NEU4 changes the entire glycosylation pattern of proteins and lipids, making it more similar to that of differentiated GBM cells and drastically reduces GSCs survival.
The results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt (show AKT1 Antibodies).
Overexpression of NEU4 is associated with neuroblastoma (show ARHGEF16 Antibodies).
NEU4 is involved in regulation of neuronal function by polySia degradation in mammals.
NEU4 plays an important role in control of sialyl Lewis antigen expression and its impairment in colon cancer
The NEU4 long form localizes in mitochondria, while the short form is also associated with the endoplasmic reticulum.
The NEU4 gene, identified by searching sequence databases for entries showing homologies to the human cytosolic sialidase NEU2 (show NEU2 Antibodies), maps in 2q37 and encodes a 484-residue protein.
Neu4 is a novel human lysosomal lumen sialidase
Data show that the differentiation of monocytes into macrophages is associated with regulation of the expression of at least three distinct cellular sialidases, Neu1 (show NEU1 Antibodies), 3, and 4, with specific up-regulation of the enzyme activity of only Neu1 (show NEU1 Antibodies).
Neu4 is not the only sialidase contributing to the metabolic bypass in Hexa (show HEXA Antibodies)(-/-) mice.
Neu4 is a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs.
mouse Neu4 plays an important regulatory role in neurite formation, possibly through desialylation of glycoproteins
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, neuraminidase 4