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SLC22A8 encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins (4) and Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (3) and many more products for this protein.
Showing 10 out of 52 products:
Human Polyclonal SLC22A8 Primary Antibody for IF (p), IHC (p) - ABIN670821
Zhou, Yu, Zhang, Liu, Lu: Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice. in Planta medica 2014
Show all 2 references for ABIN670821
Cow (Bovine) Polyclonal SLC22A8 Primary Antibody for WB - ABIN2776870
Windass, Lowes, Wang, Brown: The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. in The Journal of pharmacology and experimental therapeutics 2007
The putative promoter sequences from hOAT1 (SLC22A6 (show SLC22A6 Antibodies)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Antibodies)-3) in drug transportation.
Findings suggest that OCT3 (show POU5F1 Antibodies) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.
The markers of EMT (show ITK Antibodies) were detected by using Western blot.
PPIs inhibit [(3)H]MTX (show MTX1 Antibodies) transport via hOAT3 inhibition.
Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3 (show OCT3 Antibodies)) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (show CHDH Antibodies)).
The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.
Pemetrexed is a superior substrate to methotrexate for hOAT3.
Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3 (show POU5F1 Antibodies).
In HEK293-Flp (show HPD Antibodies)-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].
Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 (show POU5F1 Antibodies) in mice.
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (show SLC22A6 Antibodies) and OAT3).
Study showed that few, if any, 5-HT (show DDC Antibodies) neurons in the dorsal raphe are resistant to loss of Pet-1 (show FEV Antibodies) for expression of Slc22a3 (show OCT3 Antibodies)
These results demonstrate that OCT3 (show POU5F1 Antibodies) is responsible for metformin accumulation and secretion in salivary glands.
Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
Oat3 also plays a role in bioenergetic pathways.
At the protein level, mOat3 and mOat1 (show SLC22A6 Antibodies) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (show SLC22A6 Antibodies) is male dominant due to androgen stimulation.
Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Antibodies), Slc22a2 (show SLC22A2 Antibodies) and Slc22a3 (show OCT3 Antibodies) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Antibodies)+/-renal tumours.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.
solute carrier family 22 member 8
, organic anion transporter 3
, solute carrier family 22 ,member 8
, renal organic anion transporter 3
, reduced in osteosclerosis transporter
, solute carrier family 22, member 8
, EMT organic cation transporter 3
, extraneuronal monoamine transporter
, organic cation transporter 3
, solute carrier family 22 (extraneuronal monoamine transporter), member 3
, solute carrier family 22 member 3
, solute carrier family 22, member 3