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Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 Proteins (SLC3A2)

SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein. Additionally we are shipping SLC3A2 Antibodies (203) and SLC3A2 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC3A2 17254 P10852
SLC3A2 6520 P08195
SLC3A2 50567 Q794F9
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Top SLC3A2 Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$437.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$809.60
Details

SLC3A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
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Human , , , , , ,
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Rat (Rattus) , ,
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Top referenced SLC3A2 Proteins

  1. Rat (Rattus) SLC3A2 Protein expressed in Human Cells - ABIN2009510 : Torrents, Estévez, Pineda, Fernández, Lloberas, Shi, Zorzano, Palacín et al.: Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric ... in The Journal of biological chemistry 1999 (PubMed)
    Show all 7 references for ABIN2009510

  2. Human SLC3A2 Protein expressed in Human Cells - ABIN2005111 : Pfeiffer, Rossier, Spindler, Meier, Kühn, Verrey: Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. in The EMBO journal 1999 (PubMed)
    Show all 7 references for ABIN2005111

  3. Mouse (Murine) SLC3A2 Protein expressed in Human Cells - ABIN2008333 : Bröer, Wagner, Lang, Bröer: Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance. in The Biochemical journal 2000 (PubMed)
    Show all 7 references for ABIN2008333

  4. Human SLC3A2 Protein expressed in HEK-293 Cells - ABIN2180859 : Mastroberardino, Spindler, Pfeiffer, Skelly, Loffing, Shoemaker, Verrey: Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. in Nature 1998 (PubMed)
    Show all 3 references for ABIN2180859

More Proteins for Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) Interaction Partners

Mouse (Murine) Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) interaction partners

  1. ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion.

  2. CD98hc mediated this stiffness sensing by increasing Rho kinase (show ROCK2 Proteins) (ROCK) activity.

  3. Mice lacking CD98hc in B cells are protected from experimental autoimmune encephalomyelitis.

  4. CD98 heavy chain is crucial for T cell-mediated autoimmune colitis. CD98 heavy chain deficiency in T cells is involved in increasing induced regulatory T cells.

  5. The role of SLC3A2 in keratinocytes is not in cell adhesion but, instead, in cell proliferation and migration through modulating integrin signaling by the Src (show SRC Proteins)-RhoA (show RHOA Proteins) pathway.

  6. CD98-dependent amino acid transport increased renal tubular epithelial cell proliferation is mediated by Erk (show EPHB2 Proteins) and p38 MAPK (show MAPK14 Proteins) signaling.

  7. Investigated the contribution of CD98 to intestinal tumorigenesis in Apc (show APC Proteins)(Min/+) mice and the underlying mechanism of action.

  8. when the CD98hc deficient macrophages were stimulated with either IFN-gamma (show IFNG Proteins)/LPS (show TLR4 Proteins) or IL-4 (show IL4 Proteins), the production of NO(2) or arginase-I (show ARG1 Proteins) decreased in comparison to that observed in the control macrophages

  9. T cell-specific deficiency in CD98hc can contribute to cardiac allograft permanent acceptance correlating with the attenuation of lymphocyte migration and by increasing the generation of regulatory T cells.

  10. Taken together, these observations show that the combination of an inflammatory context and intestinal epithelial cell expression of CD98 affects the regulation of miRNA expression in colonic epithelial and immune cells.

Human Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) interaction partners

  1. Study demonstrated that the mRNA expression levels of the two system xc- subunits, SLC7A11 and SLC3A2, in peripheral white blood cells are lowered in patients with schizophrenia than healthy individuals

  2. ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion.

  3. exposure to diesel exhaust particle extract induces functional overexpression of the amino acid transporter (show SLC43A2 Proteins) LAT1 (show LAT Proteins)/CD98hc in lung cells

  4. The detergent-induced stabilization of the purified human 4F2hc-LAT2 (show LAT2 Proteins) complex presented here paves the way towards its crystallization and structure determination at high-resolution

  5. HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion.

  6. CD98-mediated phosphorylation of focal adhesion kinase may facilitate the assembly of pro-tumorigenic signaling complexes and the subsequent amplification of a positive feedback loop of CD98/integrins/FAK (show PTK2 Proteins)/RhoA (show RHOA Proteins)/ROCK.

  7. data suggest that genetic variation of rs1059292 in CD98 gene may affect clinical outcome of NSCLC in Chinese population

  8. Overexpression of CD98, integrin beta1, integrin beta3 and Fak (show PTK2 Proteins) is associated with the progression and liver metastases of colorectal cancer

  9. Studied and identified the eukaryotic protein CD98hc as a partner for Brucella T4SS subunit VirB2.

  10. CAP-D3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells.

SLC3A2 Protein Profile

Protein Summary

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with SLC3A2

  • solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (slc3a2)
  • solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (SLC3A2)
  • solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (Slc3a2)
  • solute carrier family 3 (amino acid transporter heavy chain), member 2 (SLC3A2)
  • solute carrier family 3 (amino acid transporter heavy chain), member 2 (Slc3a2)
  • 4F2 protein
  • 4F2HC protein
  • 4T2HC protein
  • AI314110 protein
  • CD98 protein
  • CD98HC protein
  • Ly-10 protein
  • Ly-m10 protein
  • Ly10 protein
  • MDU1 protein
  • MGC53951 protein
  • MGC53965 protein
  • Mgp-2hc protein
  • NACAE protein
  • SLC3A2 protein

Protein level used designations for SLC3A2

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 , solute carrier family 3, member 2 , 4F2 cell-surface antigen heavy chain , CD98 antigen , CD98 heavy chain , antigen identified by monoclonal antibodies 4F2 , type II transmembrane protein , 4F2hc , blood-brain barrier large neutral amino acid transporter heavy chain 4F2 , antigen defined by monoclonal antibody 4F2, heavy chain , antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43 , lymphocyte activation antigen 4F2 large subunit , monoclonal antibody 44D7

GENE ID SPECIES
379133 Xenopus laevis
379938 Xenopus laevis
451271 Pan troglodytes
483777 Canis lupus familiaris
507107 Bos taurus
100064046 Equus caballus
100144589 Sus scrofa
100172374 Pongo abelii
100585864 Nomascus leucogenys
17254 Mus musculus
100009363 Oryctolagus cuniculus
6520 Homo sapiens
50567 Rattus norvegicus
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