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SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (45) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (5) and many more products for this protein.
Showing 10 out of 98 products:
Human Polyclonal SLC6A4 Primary Antibody for IEM, ICC - ABIN617913
Sur, Betz, Schloss: Localization of the serotonin transporter in rat spinal cord. in The European journal of neuroscience 1997
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Human Polyclonal SLC6A4 Primary Antibody for IF (p), IHC (p) - ABIN735983
Wang, Liu, Wang, Bai, Zhang, Sun, Wang: Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats. in Human & experimental toxicology 2013
Show all 6 Pubmed References
Human Polyclonal SLC6A4 Primary Antibody for ELISA, WB - ABIN250555
Voeller: Attention-deficit hyperactivity disorder (ADHD). in Journal of child neurology 2004
Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).
These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Antibodies) storage, and potentially for function of dSERT.
SERT protects trophoblast cells against apoptotic cell death in caspase-3 (show CASP3 Antibodies) independent pathway by terminating the 5-HT (show DDC Antibodies) signaling.
Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT (show DDC Antibodies). These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells.
This study showed that the decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter.
Serotonin Transporter Inhibition by Toll-Like Receptor 2 (show TLR2 Antibodies) Activation
Data show that SERT associates with ASCT2 (show SLC1A5 Antibodies) (alanine-serine-cysteine-threonine 2), a member of the solute carrier (show SERTAD2 Antibodies) 1 family co-expressed with SERT in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.
In mice, SERT expression was suppressed in inflamed mucosa and continuously observed with low-grade mucosal inflammation during colitis healing.
these data demonstrate that sustained SERT loss of function reduces 5-HT2AR surface expression that is critical for the synergistic activation of alphaIIbbeta3 by 5-HT and ADP.
Results suggest a novel mechanism through which increased expression of the 5-HTT gene can alter the microcircuitry of the amygdala
miR (show MLXIP Antibodies)-24 played a role in the pathogenesis of IBS probably through regulating SERT expression.
Results reveal dissimilarities in adult behavior and neurotransmission arising from developmental exposure to different widely prescribed antidepressants that are not recapitulated by genetic SERT insufficiency
This paper contains kinetics data of serotonin receptor (show HTR1B Antibodies) binding.
Rhesus monkeys carrying the short rh5 (show RHO Antibodies)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.
An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.
Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.
A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Antibodies) site is found in animals possessing this polymorphism.
We find that the short allele of the rh5 (show RHO Antibodies)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.
rh5 (show RHO Antibodies)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.
short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.
carriers of the low-expressing rh5 (show RHO Antibodies)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.
evidence that the short allelic variant in rh5 (show RHO Antibodies)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants
this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors
Patient with 5-HTTLPR proteins have a higher risk of developing affective psychosis than schizophrenia without affective symptoms
Altered SLC6A4 methylation associates with greater socio-emotional stress sensitivity in 3-month-old very preterm infants.
Results indicate that the interaction between OCT1 (show POU2F1 Antibodies) and SERT genes might play an important role in metformin gastrointestinal intolerance.
Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates
SERT/serotonin pathway is crucial in the process of pulmonary vascular remodeling/adaptation at birth and plays a key role in the pathobiology of as alveolar capillary dysplasia with misalignment of pulmonary veins
Importance of MAOA (show MAOA Antibodies) and 5-HTTLPR polymorphisms in the treatment of spousal violence and drinking in men in batterer intervention programs.
We tested the hypothesis that gestational diabetes mellitus alters the DNA methylation (show HELLS Antibodies) pattern of the fetal serotonin transporter gene (SLC6A4), and examined the functional relevance of DNA methylation (show HELLS Antibodies) for regulation of the SLC6A4 expression in the placenta.
A systematic review and secondary data meta-analysis investigating the role of 5-HTTLPR x environment and psychological factor interactions in risk for eating pathology. Results of the secondary data meta-analysis revealed that when testing deviations from an additive model of interaction, the experience of abuse interacted with the s-allele of 5-HTTLPR to predict increased risk of bulimia-spectrum eating pathology.
The short allele of the 5-HTTLPR gene is linked to enhanced neural mechanisms of selective attention.
Polymorphisms of the glucocorticoid receptor (show NR3C1 Antibodies) gene influenced both the basal state of the hypothalamus-pituitary-adrenal axis as well as self-perceived stress. The mineralocorticoid receptor (show NR3C2 Antibodies) gene only associated with self-perceived stress and 5-HTT only with the cortisol awakening response.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
, drosophila serotonin transporter
, cocaine-sensitive serotonin transporter
, sodium-dependent serotonin transporter
, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
, solute carrier family 6 member 4
, sodium-dependent serotonin transporter-like
, plasma membrane transporter for serotonin reuptake
, 5-hydroxytryptamine (serotonin) transporter
, 5HT transporter
, Sodium-dependent serotonin transporter (5HT transporter) (5HTT)
, transmembrane 5-HT transporter
, 5-hydroxytryptamine transporter
, Na+/Cl- dependent serotonin transporter
, serotonin transporter 1
, Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
, solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
, solute carrier family 6, member 4
, serotnin transporter