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Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (SLC6A4)

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies (97) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC6A4 15567 Q60857
SLC6A4 6532 P31645
Rat SLC6A4 SLC6A4 25553 P31652
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Top Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human GST tag,S tag,His tag   100 μg Log in to see 11 to 13 Days
$774.40
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SLC6A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,

Top referenced Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins

  1. Human SLC6A4 Protein expressed in HEK-293 Cells - ABIN2732177 : Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. in Neurotoxicology 2015 (PubMed)

More Proteins for Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaction Partners

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  2. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Proteins) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Data show that SERT associates with ASCT2 (show SLC1A5 Proteins) (alanine-serine-cysteine-threonine 2), a member of the solute carrier (show SERTAD2 Proteins) 1 family co-expressed with SERT in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.

  2. In mice, SERT expression was suppressed in inflamed mucosa and continuously observed with low-grade mucosal inflammation during colitis healing.

  3. these data demonstrate that sustained SERT loss of function reduces 5-HT2AR surface expression that is critical for the synergistic activation of alphaIIbbeta3 by 5-HT and ADP.

  4. Results suggest a novel mechanism through which increased expression of the 5-HTT gene can alter the microcircuitry of the amygdala

  5. miR (show MLXIP Proteins)-24 played a role in the pathogenesis of IBS probably through regulating SERT expression.

  6. Results reveal dissimilarities in adult behavior and neurotransmission arising from developmental exposure to different widely prescribed antidepressants that are not recapitulated by genetic SERT insufficiency

  7. Increased 5-HTT expression reduces negative cognitive bias for stimuli with uncertain outcomes.

  8. Cohabitation with a female (mating experience) reduced anxiety-like behavior and increased exploratory locomotion in the open field test in male heterozygous 5-HTT knockout mice but did not affect wildtype mice

  9. The serotonin transporter gene (5-HTT/SLC6A4)-linked polymorphic region (5-HTTLPR) is assumed to modulate the interaction between developmental stress exposure and emotional dysregulation later in life.

  10. This study demonstrated that the cell signaling level, probably contributes to the moderation of the anxiety phenotype in 5-HTT(-/-) mice.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. This paper contains kinetics data of serotonin receptor (show HTR1B Proteins) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  2. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  3. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Proteins) site is found in animals possessing this polymorphism.

  4. We find that the short allele of the rh5-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  5. rh5-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  6. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  7. carriers of the low-expressing rh5-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  8. evidence that the short allelic variant in rh5-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  9. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

  10. Data sho (show SPRN Proteins) wthat genotype (serotonin transporter promoter) acted independently in interaction with social condition to affect behavioral responses.

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. The frequency of SLa (show SLA Proteins) genotype of 5-HTTLPR polymorphism was found to be higher in patients with obsessive compulsive disorder compared with healthy controls

  2. 5-HTTLPR does not seem to be associated with eating disorders in general, or with anorexia nervosa or bulimia nervosa in particular. [review, meta-analysis]

  3. the kinetics of intracellular Na(+) release and K(+) (or H(+)) binding result in a voltage-independent rate-limiting step where SERT may return to the outward-facing state in a KCl- or HCl-bound form.

  4. Short serotonin transporter allele carriers have reduced neural responses (P1) during early sensory attention to facial expressions compared to long allele carriers.

  5. Data show that SERT associates with ASCT2 (show SLC1A5 Proteins) (alanine-serine-cysteine-threonine 2), a member of the solute carrier (show SERTAD2 Proteins) 1 family co-expressed with SERT in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.

  6. SERT expression is downregulated in healing colonic mucosa of ulcerative colitis patients and that suppression may be dependent on the presence of remaining low-grade colonic inflammation.

  7. The findings do not suggest a positive association between premature ejaculation and 5-HTTLPR (serotonin transporter gene promoter) polymorphism.

  8. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  9. findings suggest that the development of depressive symptoms in winter is associated with a failure to downregulate serotonin transporter levels appropriately during exposure to the environmental stress of winter.

  10. Associations between serotonin transporter gene and tryptophan hydroxylase 1 (show TPH1 Proteins) polymorphisms and several Temperament and Character Inventory dimensions and subdimensions were revealed in subjects with bipolar disorder.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Protein Profile

Protein Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene names and symbols associated with SLC6A4

  • Serotonin transporter (SerT)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (slc6a4)
  • serotonin transporter (SERT)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4)
  • solute carrier family 6 (neurotransmitter transporter), member 4 (SLC6A4)
  • solute carrier family 6 (neurotransmitter transporter), member 4 (Slc6a4)
  • 5-HTT protein
  • 5-HTTLPR protein
  • 5HTT protein
  • AI323329 protein
  • CG4545 protein
  • Dmel\\CG4545 protein
  • DmSerT protein
  • dsert protein
  • dSERT1 protein
  • hSERT protein
  • Htt protein
  • OCD1 protein
  • Sert protein
  • SERT1 protein
  • SLC6A4 protein

Protein level used designations for SLC6A4

serotonin transporter , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , solute carrier family 6 member 4 , sodium-dependent serotonin transporter-like , huntingtin , plasma membrane transporter for serotonin reuptake , 5-hydroxytryptamine (serotonin) transporter , 5HT transporter , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , transmembrane 5-HT transporter , 5-hydroxytryptamine transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , serotnin transporter

GENE ID SPECIES
37895 Drosophila melanogaster
404747 Gallus gallus
468201 Pan troglodytes
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
443491 Ovis aries
15567 Mus musculus
282365 Bos taurus
100135619 Cavia porcellus
574140 Macaca mulatta
6532 Homo sapiens
25553 Rattus norvegicus
491184 Canis lupus familiaris
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