You are viewing an incomplete version of our website. Please click to reload the website as full version.

Sortilin-Related Receptor, L(DLR Class) A Repeats Containing Proteins (SORL1)

SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. Additionally we are shipping SORL1 Antibodies (89) and SORL1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SORL1 6653 Q92673
Mouse SORL1 SORL1 20660 O88307
Rat SORL1 SORL1 300652  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SORL1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SORL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) Interaction Partners

Human Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) interaction partners

  1. Elevated sLR11 levels may increase the cardiovascular disease risk especially in subjects with delayed clearance of triglyceride-rich remnants, such as in familial hypercholesterolemia patients.

  2. CLF-1 (show CRLF1 Proteins), based on its binding site for CLC (show CLC Proteins) and on two additional and independent sites for CNTFRalpha (show CNTFR Proteins) and sorLA, is a key player in CLC (show CLC Proteins) and CNTFRalpha (show CNTFR Proteins) signaling and turnover.

  3. Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma

  4. sLR11 levels in humans are shown to positively correlate with body mass index and adiposity.

  5. The findings of this study confirm that SORL1 is associated with Alzheimer's Disease and might be a potential tool for identifying Mild Cognitive Impairment subjects at high risk of conversion to lzheimer's Disease.

  6. Study suggested a sex-moderated association of the SORL1 rs2070045 polymorphism and executive function in healthy elderly

  7. Mutating recombinant human SORLA, disrupting retromer binding caused retrograde-sorting defect, endosomal accumulation, TGN (show TG Proteins), depletion, and enhanced APP (show APP Proteins) processing. Disrupting the GGA interaction increased Abeta (show APP Proteins) via defective anterograde lysosomal targeting.

  8. genetic polymorphism controls protein expression, which directly regulates the amount of Abeta (show APP Proteins) peptides implicated in Alzheimer's disease

  9. SORL1 may be implicated in the downstream pathology in AD.

  10. SORL1 risk variants influenced microstructure of white matter tracts with known susceptibility in Alzheimer's disease with consistent effect from childhood onward and predicted lower levels of mRNA expression

Mouse (Murine) Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) interaction partners

  1. Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.

  2. Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.

  3. using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (show TRAF3IP2 Proteins) exon 2, PPARG (show PPARG Proteins) exon 6) at single nucleotide resolution in the mouse liver

  4. Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR (show ADRA2A Proteins)) signaling disrupts transgenic amyloid precursor protein (APP (show APP Proteins)) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.

  5. SORLA-mediated trafficking of TrkB (show NTRK2 Proteins) enhances the response of neurons to BDNF (show BDNF Proteins).

  6. SorLA acts as sorting receptor for the GDNF (show GDNF Proteins)/GFRalpha1 (show GFRA1 Proteins) complex, directing it from the cell surface to endosomes.

  7. sLR11 regulates the hypoxia-enhanced adhesion of HSPCs via an uPAR (show PLAUR Proteins)-mediated pathway that stabilizes the hematological pool size by controlling cell attachment to the BM niche.

  8. SorLA expression might be critical not only for amyloid-related pathology but also for other cellular processes altered in Alzheimer disease.

  9. overexpression of SorLA increased migration of THP-1 monocytes to monocyte chemoattractant protein-1 (show CCL2 Proteins) with a coincident increase in UPAR (show PLAUR Proteins) expression.

  10. Sorcs1 (show SORCS1 Proteins) deficiency might be a common genetic risk factor underlying the predisposition to Alzheimer disease that is associated with type 2 diabetes.

SORL1 Protein Profile

Protein Summary

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

Gene names and symbols associated with SORL1

  • sortilin-related receptor, L(DLR class) A repeats containing (sorl1)
  • sortilin-related receptor, L(DLR class) A repeats-containing (SORL1)
  • sortilin-related receptor, L(DLR class) A repeats-containing (LOC100226349)
  • sortilin-related receptor, L(DLR class) A repeats-containing (sorl1)
  • sortilin-related receptor, L(DLR class) A repeats containing (SORL1)
  • sortilin-related receptor, LDLR class A repeats-containing (Sorl1)
  • 2900010L19Rik protein
  • AI596264 protein
  • AW261561 protein
  • C11orf32 protein
  • gp250 protein
  • Lr11 protein
  • LRP9 protein
  • mSorLA protein
  • RGD619914 protein
  • SORL1 protein
  • SorLA protein
  • SorLA-1 protein

Protein level used designations for SORL1

sortilin-related receptor, L(DLR class) A repeats containing , sortilin-related receptor, L(DLR class) A repeats-containing , sortilin-related receptor-like , LDLR relative with 11 ligand-binding repeats , low-density lipoprotein receptor relative with 11 ligand-binding repeats , mosaic protein LR11 , sortilin-related receptor , sorting protein-related receptor containing LDLR class A repeats , LR11 , sorLA , sorLA-1

GENE ID SPECIES
100566946 Anolis carolinensis
582560 Strongylocentrotus purpuratus
713011 Macaca mulatta
100024063 Monodelphis domestica
100071572 Equus caballus
100073504 Ornithorhynchus anatinus
100226349 Taeniopygia guttata
100490681 Xenopus (Silurana) tropicalis
100524036 Sus scrofa
6653 Homo sapiens
479408 Canis lupus familiaris
533166 Bos taurus
395998 Gallus gallus
100009378 Oryctolagus cuniculus
20660 Mus musculus
300652 Rattus norvegicus
Selected quality suppliers for SORL1 Proteins (SORL1)
Did you look for something else?