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The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Antibodies (281) and SP1 Proteins (9) and many more products for this protein.
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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A ELISA Kits), sp1 and sod1 (show SOD1 ELISA Kits) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
expression of the evolutionarily conserved slit2 (show SLIT3 ELISA Kits) Gene Promoter Requires Sp1 (show PSG1 ELISA Kits)
we verified that miR (show MLXIP ELISA Kits)-892b regulates the p19ARF/cyclin D1 (show CCND1 ELISA Kits)/CDK6 (show CDK6 ELISA Kits) and Sp-1 (show PSG1 ELISA Kits)/MMP-9 (show MMP9 ELISA Kits) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.
Study provides evidence that Mef2c (show MEF2C ELISA Kits) cooperated with Sp1 (show PSG1 ELISA Kits) to activate human AQP1 (show AQP1 ELISA Kits) transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells indicating that AQP1 (show AQP1 ELISA Kits) is a direct target of Mef2c (show MEF2C ELISA Kits) in regulating angiogenesis and vasculogenesis of endothelial cells.
MiR (show MLXIP ELISA Kits)-375 inhibited the proliferation, invasion and migration by directly targeting SP1 (show PSG1 ELISA Kits).
High SP1 (show PSG1 ELISA Kits) expression is associated with ovarian cancer.
miR (show MLXIP ELISA Kits)-326 can restore CDDP chemosensitivity in the human lung adenocarcinoma cells by targeting SP1 (show PSG1 ELISA Kits), and HOTAIR upregulate the expression of miR (show MLXIP ELISA Kits)-326 target gene SP1 (show PSG1 ELISA Kits).
TEAD1 (show TEAD1 ELISA Kits) could enhance the expression levels of SP1 (show PSG1 ELISA Kits), by directly binding to its promoter.
site-directed mutagenesis of potential SP1 (show PSG1 ELISA Kits) binding sites diminished both DNA-protein complexes and SP1 (show PSG1 ELISA Kits)-mediated upregulation of URG-4 (show URGCP ELISA Kits) promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP (show URGCP ELISA Kits) that has a pivotal role in cancer progression.
Sp1 (show PSG1 ELISA Kits) up-regulated TMEPAI (show PMEPA1 ELISA Kits) protein expression, as well as Sp1 (show PSG1 ELISA Kits) promoting TMEPAI (show PMEPA1 ELISA Kits)-induced cell proliferation.
the results of this study suggest that the miR (show MLXIP ELISA Kits)-24/SP1 (show PSG1 ELISA Kits) pathway contributed to the reduction in radioresistance in human NPC (show NPC1 ELISA Kits) and that it may thus represent a therapeutic target.
study demonstrates the co-expression of DLX3 (show DLX3 ELISA Kits), PPARG (show PPARG ELISA Kits) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH ELISA Kits) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN ELISA Kits) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP ELISA Kits) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP ELISA Kits) promoter and its activity.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR (show MLXIP ELISA Kits)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 (show COL11A1 ELISA Kits) gene in chondrocytes.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 ELISA Kits) gene was regulated by E2F1 (show E2F1 ELISA Kits) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 ELISA Kits) and myogenin (show MYOG ELISA Kits).
Data indicate that Sp1 and AP-1 (show JUN ELISA Kits)-related factors are involved in the regulation of MFG-E8 (show MFGE8 ELISA Kits) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor (show SP3 ELISA Kits) members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 ELISA Kits) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 ELISA Kits) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 ELISA Kits) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1