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The protein encoded by SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. Additionally we are shipping SP1 Antibodies (238) and SP1 Proteins (8) and many more products for this protein.
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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A ELISA Kits), sp1 and sod1 (show SOD1 ELISA Kits) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
we predicted CG-rich region of miR (show MLXIP ELISA Kits)-23a-27a-24-2 cluster (miR (show MLXIP ELISA Kits)-23a, miR (show MLXIP ELISA Kits)-27a, and miR (show MLXIP ELISA Kits)-24-2)promoter and detected the methylation status in the region spanning two SP1 (show PSG1 ELISA Kits) sites.
Bioinformatics analysis demonstrated that SP1 (show PSG1 ELISA Kits) represented a common transcription factor associated with changes in metastasis-related factors. Blocking SP1 (show PSG1 ELISA Kits) activity by an inhibitor suppressed the starvation-plus-radiation treatment-mediated enhancement of U251 cell metastasis.
Results provide evidence that Sp1 (show PSG1 ELISA Kits) positively controls TIAM2S transcription and that Sp1 (show PSG1 ELISA Kits)-mediated transcriptional activation is essential for TIAM2S ectopic expression in liver cancer cells.
The growth-inhibitory effects of mithramycin in malignant pleural mesotheliomas cells were recapitulated by combined SP1 (show PSG1 ELISA Kits) knockdown/p53 (show TP53 ELISA Kits) overexpression
results suggest that Sp1 (show PSG1 ELISA Kits) is an anti-senescence transcription factor in the telomere uncapping-induced senescence and that down-regulation of Sp1 (show PSG1 ELISA Kits) leads to the senescence via down-regulation of the nuclear transport
Our findings demonstrate that SP1 (show PSG1 ELISA Kits) attenuates mutant LRRK2 (show LRRK2 ELISA Kits)-induced PD-like phenotypes and plays a neural protective role.
Ginsenoside Rg3 induces FUT4 (show FUT4 ELISA Kits)-mediated apoptosis in H. pylori CagA (show S100A8 ELISA Kits)-treated gastric cancer cells by regulating SP1 (show PSG1 ELISA Kits) and HSF1 (show HSF1 ELISA Kits) expressions
miR (show MLXIP ELISA Kits)-23b/SP1 (show PSG1 ELISA Kits)/c-myc (show MYC ELISA Kits) forms a feed-forward loop supporting multiple myeloma cell growth
these data indicate that activation of EGFR (show EGFR ELISA Kits) enhanced the expression of P2X7R (show P2RX7 ELISA Kits) in neuroblastoma (show ARHGEF16 ELISA Kits) cells lacking trophic support, being PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/PKC signaling pathway and Sp1 (show PSG1 ELISA Kits) mediating this pro-survival outcome
This is the first study indicating that Sp1 (show PSG1 ELISA Kits) signaling plays an important role in the regulation of human LRRK2 (show LRRK2 ELISA Kits) gene expression.
study demonstrates the co-expression of DLX3 (show DLX3 ELISA Kits), PPARG (show PPARG ELISA Kits) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH ELISA Kits) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN ELISA Kits) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP ELISA Kits) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP ELISA Kits) promoter and its activity.
miR (show MLXIP ELISA Kits)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 (show COL11A1 ELISA Kits) gene in chondrocytes.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 ELISA Kits) gene was regulated by E2F1 (show E2F1 ELISA Kits) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 ELISA Kits) and myogenin (show MYOG ELISA Kits).
Data indicate that Sp1 and AP-1 (show JUN ELISA Kits)-related factors are involved in the regulation of MFG-E8 (show MFGE8 ELISA Kits) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor (show SP3 ELISA Kits) members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 ELISA Kits) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 ELISA Kits) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 ELISA Kits) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
Data suggest that retinoic acid and GM-CSF (show CSF2 ELISA Kits)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 ELISA Kits)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor (show RXRB ELISA Kits) complex to the Aldh1a2 (show ALDH1A1 ELISA Kits) promoter.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1